Spiro[fluorene-9,9′-xanthene] (SFX) bipolar hosts bearing one, two and three quinolyl substituents, namely SFX-bPy, SFX-DbPy and SFX-TbPy, were designed and synthesized for phosphorescent organic light emitting diodes (PhOLEDs). The successive substitution of quinoline at 2′, 2 and 7′ positio...
A novel spiro(fluorene-9,9′-xanthene) skeleton bis(ether amine) monomer, 2′,7′-bis(4-amino-2-trifluoromethylphenoxy)-spiro(fluorene-9,9′-xanthene), was prepared through a simple acid-catalyzed condensation reaction of 9-fluorenone with resorcinol to form the spiro framework through an sp ...
The stereoselectivity of the ring expansion of oxaspiropentanes to cyclobutanols induced by Grignard reagents has been studied. It has been found that the reaction occurs through the intermediacy of a cyclobutanone, formed stereospecifically, whereas the attack of the Grignard reagent on the car...
Perdeutero-spiropentane (C5D8) has been synthesized, and infrared and Raman spectra are reported for the first time. Wavenumber assignments are made for most of the fundamental vibrational states. Gas phase infrared spectra were recorded at a resolution (0.002cm−1) sufficient to resolve individu...
Infrared spectra of spiropentane (C 5 H 8 ) have been recorded at a resolution (0.002cm −1 ) sufficient to resolve for the first time individual rovibrational lines. This initial report presents the ground state rotational constants for this molecule determined from the d...
The diazoketone derived from tricyclo[4.1.0.0 1 , 3 ]heptan-4-one on photolysis in dimethylamine leads to a novel product that appears to be formed via a cyclopropylcarbene rearrangement followed by dimethylamine addition and the cleavage of one of the cyclobutane rings. In a ma...
The dimethyldioxirane (DMD) promoted oxidative decomplexation of Fischer carbene complex 1, which contains a conjugated enamino moiety, was investigated. Thus, treatment of 1 with 3 molecular equivalents of DMD afforded a 52% yield of amide 3 as unique isolable organic product. When the reacti...
A new hybrid material (3) consisting of trifluoromethyl ketone (TFMK) moieties, immobilized on silica through an appropriate spacer, was synthesized and characterized. Lacking easily oxidizable functionalities in the spacer chain, this material proved to be an excellent catalyst in heterogeneous...
The synthesis of tetraethyl 1,2‐epoxy‐2‐aryl ethylgembisphosphonates by direct epoxidation of 2‐aryl,vinyl‐1,1‐diphosphonate derivatives with ethyl methyldioxirane generated in situ from potassium hydrogen monopersulfate (caroate) and butanone in a phase transfer system is reported. The ep...
AM1 and ab initio calculations were performed on 1-amino-2-methanoyloxirene (1-amino-2-formyloxirene), the two corresponding oxo carbenes ( ketocarbenes ) resulting from alternative C-O cleavage, and the transition states linking these species. The purpose was to see if delocalization of elec...
The nature of the stationary point of oxirene, cyclic C 2 H 2 O, has been examined using selected GGA and hybrid functionals in combination with a number of basis sets. All GGA functionals (BLYP, BP91, PBE, HCTH, HCTH147, and HCTH407) predict the stationary point to be a transiti...
Stationary points on the oxirene-ketene potential energy surface (PES) are determined using Kohn-Sham density functional theory (DFT) with the B3LYP, B97-1, and B97-2 hybrid exchange-correlation energy functionals. B3LYP and B97-1 predict oxirene to be a transition state, which is at variance wi...
Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine mo...
Recently, acremolin (4), a novel modified base, was isolated from a marine-derived fungus and claimed to possess a structure with a 1H-azirine moiety. It is shown now that the reported NMR data are not compatible with this antiaromatic heterocycle, which should be an extremely unstable compound....
Tissue accumulation of arginine (Arg), N-acetylarginine (NA), argininic acid (AA) and homoarginine (HA) occurs in hyperargininemia, an inborn error of the urea cycle. In the present study, we investigated the in vitro effects of Arg, NA, AA and HA on NTPDase1 and 5'-nucleotidase activities from ...
We, herein, investigated the in vitro effects of argininic acid on thiobarbituric acid-reactive substances (TBA-RS), total sulfhydryl content and on the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood, kidney a...
We describe the synthesis, pharmacological properties, and structures of antidiuretic agonists, arginine vasopressin (AVP) and [d-Arg8]-vasopressin (DAVP), and their inverso analogues. The structures of the peptides are studied based on micellar and liposomic models of cell membranes using CD sp...
Gene therapy has been considered as an alternative treatment for glioblastoma therapy. In this study, a glioblastoma‐specific suicide gene, pEpo–NI2–SV–TK, was delivered into the intracranial glioblastoma model using reducible poly(oligo‐d‐arginines) (rPOA). pEpo–NI2–SV–TK has the eryth...
We previously identified a novel antimicrobial peptide with a broad spectrum bactericidal activity from human hepatitis B virus (HBV) core protein (HBc) arginine-rich domain (ARD). We compared the antimicrobial activities of HBcARD peptides from different hepadnaviruses which share similar amino...
6-diazo-5-oxo-l-norleucine (DON) exerts a growth inhibitory effect selectively on the neuroendocrine tumour cell line BON and is proposed as an antitumour drug. The mechanism behind this has not yet been clarified. In the present study, transmission electron microscopy was used for the assessmen...
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