The Stille cross-coupling reactions of 1,4- and 1,3-bis(trialkylstannyl)benzenes 2 or 3 with 9-benzyl-6-chloropurine (1) led either to mono-coupled 4- or 3-[(tributylstannyl)phenyl]benzenes 5a and 5b or to bis(9-benzylpurin-6-yl)benzenes (4a or 4b) depending on the ratio of the starting compound...
1,3,4-Thiadiazole derivatives bearing Schiff base moieties were designed, synthesized, and their tyrosinase inhibitory activities were evaluated. Some compounds displayed potent tyrosinase inhibitory activities, especially, 4-(((5-mercapto-1,3,4-thiadiazol-2-yl)-imino)methyl)-2-methoxy-phenol (1...
The electronic absorption spectra of Schiff base namely 1-[(5-mercapto-[1,3,4]thiadiazol-2-ylimino)-methyl]-naphthalen-2-ol (H2L) was studied in organic solvents of different polarity as well as in universal buffer solutions of varying pH values at room temperature; the pKa values were calculate...
In this study, the inhibition effect of 2-((5-mercapto-1,3,4-thiadiazol-2-ylimino)methyl)phenol Schiff base (MTMP) on mild steel corrosion in 0.5 M HCl solution was studied. For this aim, electrochemical techniques such as potentiodynamic polarization curves, weight loss (WL), electrochemical im...
5-Ferrocenyl-1H-tetrazole (HFcTz) was deprotonated using alkali hydroxides or carbonates, yielding the corresponding metal salts [Li4(H2O)8(FcTz)4]·2CH3CN (1), NaFcTz (2), KFcTz (3), RbFcTz·H2O (4) and [Cs2(H2O)](FcTz)2 (5). Ca(FcTz)2·4H2O (6) was prepared by deprotonation of HFcTz with CaO u...
A New and efficient magnetic nanocatalyst has been fabricated via covalent grafting of an aza-crown ether Cu(II) complex on silica coated iron oxide support. The above mentioned magnetic nanocatalyst has been characterized by various techniques such as SEM, TEM, XRD, FT-IR, TGA and ICP. After pr...
A series of novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors was prepared via treatment of various diaryl amides with tetrachlorosilane/sodium azide. All compounds were tested in cyclooxygenase (COX) assays in vitro to determine COX-1 and COX-2 inhibitory potency and sele...
An efficient and general method has been developed for synthesis of 1- and 5-substituted 1H-tetrazoles from nitriles and amines using magnetite nanoparticles immobilized Salen Cu(II) as an efficient and recyclable catalyst. The structural and magnetic properties of functionalized magnetic silica...
5-Aryl-1H-tetrazoles (1–24) were synthesized and screened for their xanthine oxidase (XO) inhibitory activity using allopurinol as standard inhibitor (IC50 = 2.0 ± 0.01 µM). Six compounds 3, 4, 5, 9, 21, and 24 exhibited significant to weak activities with IC50 values in the range of 7.4–174...
Magnetic nanoparticle functionalized with neodymium complex as catalyst and characterized by SEM, XRD, FT-IR, TGA, EDX and ICP techniques. Then, catalytic activity of prepared catalyst was examined in the synthesis of tetrezoles and oxidation reactions in which observed short reaction time and h...
An efficient triflic acid catalyzed regioselective alkylation of 5-R-1H-tetrazoles with readily available allylcarboranes is reported. The suggested synthetic procedure allows the formation of a variety of carboranyl-substituted tetrazoles in a good yield under mild conditions. Transformations o...
This general protocol provides a wide variety of 5-substituted-1H-tetrazoles in good yields under mild reaction conditions. An efficient, green, and convenient method for the preparation of new 5-substituted-tetrazoles via microwave-assisted 1,3-dipolar cycloaddition reaction of N-aryl-2,2,2-tri...
Three novel and green nano-scale magnetic solid base catalysts (CoFe2O4@glycine-M (M = Pr, Tb and Yb)) have been synthesized and characterized by XRD, TGA, VSM, EDX, ICP-OES, SEM and FT-IR spectroscopy. These robust nanohybrid catalysts as efficient and reusable heterogeneous nanocatalyst system...
A commercially available, chiral stationary-phase was used to separate sugar enantiomers. Derivatives commonly used for the gas chromatography of carbohydrates were employed. The most generally useful was found to be the per(heptafluorobutanoyl) derivative, in which form d- and l-arabinose, fuco...
Interest in the inositol phospholipids was stimulated by the simultaneous discoveries that the products of hydrolysis of these lipids could serve as messengers to activate two synergistic signaling pathways in hormonally responsive cells, namely, inositol 1,4,5-trisphosphate which causes the rel...
E-cadherin is an adherens junction protein that forms intercellular contacts in epithelial cells. Downregulation of E-cadherin is frequently observed in epithelial tumors and it is a hallmark of epithelial–mesenchymal transition (EMT). However, recent findings suggest that E-cadherin plays a mo...
Tyrosinase is a key enzyme responsible for melanin biosynthesis and is effective in protecting skin damage caused by ultraviolet radiation. As part of ongoing efforts to discover potent tyrosinase inhibitors, we systematically designed and synthesized thirteen (E)-benzylidene-1-indanone derivati...
The ion density measured by the Ionospheric Plasma and Electrodynamics Instrument (IPEI) on board the ROCSAT -1 over the 75°E and 95°E meridian at 600km altitude has been utilized to examine the latitudinal and longitudinal distribution within the Indian sector, in particular, the north-south ...
Numbers of HLA-associated polymorphisms have been reported on HIV-1 subtypes B and C, but few on other subtypes. Here, we analyzed HLA-associated gag and nef polymorphisms in HIV-1 subtype A/E prevalent in Vietnam. We determined HLA-A, B and C genotypes in 179 HIV-1-infected Vietnamese by next g...
Non-classical class Ib MHC-E molecule is becoming an increasingly interesting component of the immune response. It is involved in both the adaptive and innate immune responses to several chronic infections including HIV-1 and, under very specific circumstances, likely mediated a unique vaccine p...
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