Publisher SummaryThis chapter investigates the properties of hopantenic acid (HOPA)—a natural homolog of pantothenic acid (PaA) containing γ-aminobutyric acid (GABA) in place of β-alanine. Its calcium salt and pharmacologic properties have been used to improve blood circulation and metabolism...
A number of new derivatives of 8-hydroxyquinoline containing both solubilising groups and groups which might sterically hinder chelation have been prepared, viz. 8-hydroxy-7-morpholino-methylquinoline-5-sulphonic acid, 8-hydroxy-7-piperidinomethylquinoline-5-sulphonic acid, 8-hydroxy-2-(3,4-dime...
The reactions of [ReOX3(PPh3)2] (X = Cl, Br) with 8-hydroxyquinoline-7-carboxylic acid (Hhquin-7-COOH) and 8-hydroxy-2-methylquinoline-7-carboxylic acid (Hhmquin-7-COOH) have been examined and [ReOX2(hquin-7-COOH)(PPh3)] and [ReOX2(hmquin-7-COOH)(PPh3)] complexes have been obtained. All the comp...
The complex-formation processes taking place in the systems containing VO(IV) and d-, l-, dl- or meso-tartaric acid or citric acid in aqueous solution were re-examined by combined use of pH potentiometry and spectroscopic (EPR and electronic absorption) methods. The results allowed a full charac...
In this extension of earlier work, the main compounds studied have been di-tert.-butylsilylene (DTBS) derivatives of hydroxylic and phenolic acids. Preparative procedures were based on those originally applied by Trost and Caldwell [Tetrahedron Lett., 22 (1981) 4999] to diols. Most substrates ga...
The interaction between the aluminum ion (Al3+) and Inogashira fulvic acid (IFA) at pH 3 was investigated using the calibration curve method for 27Al NMR spectra. The average conditional stability constant (log K) can be calculated to be 2.00–2.04 (M−1) (bidentate–monodentate) from the results...
A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structu...
A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D4 dopamine receptor subtype and was identified as a D4 antagonist via its ...
The data presented in this paper are related to the research article entitled “Novel dichloro(bis{2-[1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl-κN3]pyridine-κN})metal(II) coordination compounds of seven transition metals (Mn, Fe, Co, Ni, Cu, Zn and Cd)” (Conradie et al., 2018) [1]. This paper ...
A new and simple to use line-shape analysis method ANATOLIA (ANAlysis of TOtal LIneshApe) optimised all and 19F-19F and 19F-1H coupling constants in pentafluorobenzene (AA’BB’C’H) within 10 s. This free and open-source NMR analysis method, which works within the Bruker Topspin-4 software and ...
A series of six new thienothiophene functionalized difluoroboron bis-β-diketonates were synthesized and characterized. Their photophysical properties were investigated by UV–vis absorption, fluorescence spectroscopy and the method of CIE chromaticity in solution and powders. The results showed...
The synthesis of 3,3′-bis-7-indolylmethane derivatives is important for their further development as pharmaceutical compounds and other synthetic purposes. Herein, we describe the zinc- or acid-mediated cross-coupling reaction of 7-azaindoles with aldehydes, such as paraformaldehyde, alkyl alde...
The current study is concerned with the identification of lead molecules based on the bis-coumarin scaffold having selective urease inhibitory and antiglycation activities. For that purpose, bis-coumarins (1-44) were synthesized and structurally characterized by different spectroscopic technique...
Leukotriene B4 (LTB4), a naturally occurring pro-inflammatory product of arachidonic acid metabolism, has been associated with human inflammatory disease. This study compares the abilities of two LTB4 receptor antagonists, 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]-propoxy]ph...
The enzymatic resolution of (R,S)-2-(4-hydroxyphenoxy)propionic acid was accomplished by treatment of the methyl ester in an aqueous/organic mixture with a number of commercially available Candida rugosa lipase preparations. With toluene as the organic phase, an enantiomeric excess of 88% to >99...
The extracellular heme-thiolate peroxygenase of Agrocybe aegerita catalyzed the H2O2-dependent hydroxylation of 2-phenoxypropionic acid (POPA) to give the herbicide precursor 2-(4-hydroxyphenoxy)propionic acid (HPOPA). The reaction proceeded regioselectively with an isomeric purity near 98%, and...
The conglomerate-forming nature of 3-(2-hydroxyphenoxy)propane-1,2-diol was established by IR, DSC, and XRD methods; racemic diol could be resolved by a moderate efficiency preferential crystallization procedure.
The mycelium of Aspergillus oryzae WZ007 was successfully developed to kinetic resolution of (R, S)-ethyl-2-(4-hydroxyphenoxy) propanoate ((R, S)-EHPP) for production of (R)-ethyl-2-(4-hydroxyphenoxy) propanoate ((R)-EHPP). The key biocatalytic process parameters (pH, temperature, rotation speed...
A new bis((2-(dimethylamino)ethyl)(methyl)amido)methyl(tert-butylimido)tantalum complex was synthesized for plasma-enhanced atomic layer deposition (PEALD) of tantalum nitride (TaN) film. Using the synthesized Ta compound, PEALD of TaN was conducted at growth temperatures of 150–250 °C in comb...
TaNx thin films were grown at temperatures ranging from 200 to 375 °C using atomic layer deposition (ALD). Pentakis(dimethylamino)tantalum (PDMAT) was used as a tantalum source with either ammonia or monomethylhydrazine (MMH) as a nitrogen co-reactant. Self-limiting behaviour was observed for b...
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