Phosphates are ubiquitous in nature and represent a significantly broad field of study within the scientific community given their vital role in biology, biochemistry, pharmaceutical sciences, and synthetic organic chemistry. This chapter will highlight phosphorylation methods through P(V) and P...
Silica gel as an accessible substrate with high surface area can be modified by propyl sulfonic acid. Silica-functionalized sulfonic acid (SiO2-Pr-SO3H) as a highly efficient heterogeneous solid acid catalyst catalyzes various organic reactions and can be removed easily, recovered and reused wit...
The synthesis and biological activity of a series of novel 5-substituted-4-hydroxy-8-nitroquinazolines that may function as inhibitors of EGFR- and/or ErbB-2-related oncogenic signaling are described. These compounds were prepared by SNAr reaction of 5-chloro-4-hydroxy-8-nitroquinazoline with al...
The results of double-bond migration in alkyl allyl and allyl silyl ethers catalyzed by ruthenium complexes [RuClH(CO)(PPh3)3] and in situ forming catalytic system {[RuCl2(cod)]x} with hydride and a phosphine) are presented. The conversion of allyl to 1-propenyl ethers is quantitative. The mecha...
The oxidative coupling of phenols or phenol ethers belongs to the category of those venerable organic reactions that continue to sustain the interest of chemists even after more than a century and a half of relentless investigations. Aside from its use as a convenient means to rapidly access use...
A copper-catalyzed dehydrogenative cross-coupling reaction between unactivated ethers and simple ketones mediated by pyrrolidine has been developed. Under the catalysis of CuBr2 and in the presence of pyrrolidine, either tetrahydrofuran 2a or tetrahydropyran 2b can react smoothly with a series o...
An efficient, chemoselective, and environment-friendly method for the deprotection of tert-butyldiphenylsilyl ethers mediated by triflic acid supported on silica gel is reported. A wide range of tert-butyldiphenylsilyl ethers derived from carbohydrate and saponin residues can be smoothly cleaved...
Electrocatalytic hydrogenation and catalytic thermal hydrogenation of substituted phenols and diaryl ethers were studied on carbon-supported Rh. The rates of electrocatalytic hydrogenation increase with increasingly negative potentials, which have been related with the coverage of adsorbed hydro...
A one-step preparation of α-sulfonylated cyclic ethers has been achieved via the intermolecular sulfonylation of ethereal CH bonds. In this process, the chemoselective cleavage of the ethereal CH bond was achieved by hydrogen abstraction with photo-excited benzophenone, and the sulfonyl unit wa...
The ditertiary phosphines; [2-{di(p-tolyl)phosphino}ethyl] diphenylphosphine (pptpf) and [2-{di(m-tolyl}ethyl] diphenylphosphine (pmtpf) complexes of ruthenium of the type: [Ru(pptpf)2X2] [Ru(pmtpf)2X2] (where X = Cl,Br, I or NCS), [Ru(CO)2X2(pptpf)] and [Ru(CO)2X2(pmtpf)] (where X = Cl, Br, or ...
We synthesized and evaluated a series of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides to identify potent inhibitors of calcium-release-activated calcium (CRAC) channels with greater selectivity than voltage-operated calcium (VOC) channels. These efforts resulted in iden...
Thifensulfuron methyl (methyl 3-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate, formerly DPX-M6316) is a sulfonylurea herbicide for postemergence broadleaf weed control in wheat, barley, and soybeans. Plant response data are presented demonstrating >...
The pentadienyl anion generated by treating methyl thiophenecarboxylate with samarium diiodide/ hexamethylphosphoramide in tetrahydrofuran reacts at the C-5 position with a series of benzaldehydes and acetophenones to give the intermediates of samarium dienolates, which are trapped with the seco...
It is important to have control over the nucleation, growth and orientation of organic thin films. The present study focuses on the orientation the dipolar linear organic molecule, 4-hydroxy-4′-biphenylcarbonitrile (HBC), on aligned polyamide films. The polymer surfaces were oriented by using r...
This chapter describes the pyrolysis of alcohols, enols, phenols, di- and poly-hydroxybenzenes, and of alcohols and phenols with additional functional groups. Among the discussed alcohols are the short-chain monohydroxy primary alcohols (methanol, ethanol, etc.), monohydroxy secondary and tertia...
α-Dibenzylamino- and α-benzyloxy- derivatives of N-acetyl-(S)-4-benzyl-5,5-dimethyloxazolidin-2-one readily undergo highly stereoselective boron mediated syn-aldol reactions with a range of aromatic and aliphatic aldehydes, generating the syn-aldol products in good to excellent yields as singl...
Alkylation of lithiated N-(benzyloxyacetyl)-trans-2,5-bis(mehtoxyymethoxymethyl)- pyrrolidine proceeded with high stereoselectivity (≥96% de) and subsequent transformations of the alkylated products gave synthetically useful α-benzyloxy acids or α-hydroxy acids of high enantiomeric purity.
Recently a dramatic development of the cancer drug discovery has been shown in the field of targeted cancer therapy. Checkpoint kinase 2 (Chk2) inhibitors offer a promising approach to enhance the effectiveness of cancer chemotherapy. Accordingly, in this study many pyrimidine-benzimidazole conj...
The molecular structures of methyl 2-(methylthio)benzoate, dimethyl 2,2′-dithiodibenzoate, dimethyl 2,2′-thiodibenzoate, methyl 2-(2-nitrophenylthio)benzoate, 2,2′-dinitrodiphenyl sulphide and methyl 2-(2-nitrophenylthio)phenylacetate exhibiting S(II)⋯O(carbonyl) or S(II)⋯O—(nitro) close con...
The importance of the electrical double layer at the interface between a metal and an acid electrolyte together with its interaction with organic and inorganic molecules to produce initially electrostatic adsorption are highlighted. In some cases, a chemical bond is formed involving charge trans...
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