Cobalt (Co(II)) and copper (Cu(II)) complexes of sulfamerazine-salicylaldehyde (SS) ligand intercalated Mg/Al-layered double hydroxide [Co-SS-LDH/Cu-SS-LDH] were prepared for the antimicrobial application. Sulfamerazine and salicylaldehyde were mixed together and dissolved in methanol for the sy...
Molar electrical conductivities of three ionic sulfonamides: sodium sulfadiazine (NaSD), sodium sulfamerazine (NaSMR) and sodium sulfamethazine (NaSMT), have been determined in aqueous solution as functions of solute concentration and temperature. The values of ionic molar electrical conductivit...
A comprehensive study on the dissolution properties of three co-amorphous sulfamerazine/excipient systems, namely sulfamerazine/deoxycholic acid, sulfamerazine/citric acid and sulfamerazine/sodium taurocholate (SMZ/DA, SMZ/CA and SMZ/NaTC; 1:1 molar ratio), is reported. While all three co-former...
Solubility studies are valuable tools for the pharmaceutical industry and research centres and are currently becoming increasingly relevant in the environmental sciences field. This study presents the thermodynamic and preferential solvation analyses of solubility of sulfamerazine (SMR) in {acet...
An electrochemically conductive single-walled carbon nanotube (SWCNT) embedded poly 1,5-diaminonapthalene (DAN) modified sensor has been developed for the determination of sulfacetamide (SFA). The surface morphology of the modified sensor has been characterized by FE-SEM, which revealed good dis...
The official assay for sodium sulfacetamide, the diazotization method, does not differentiate between sulfacetamide and its hydrolytic product, sulfanilamide. A spectrophotometric method involving the formation of ferric acethydroxamate was developed for utilization in studies of the rate of hyd...
A high‐pressure liquid chromatographic method, using an adsorption column and sulfabenzamide as the internal standard, is proposed for the determination of sulfacetamide sodium and its principal hydrolysis product, sulfanilamide, in eye drops. It affords an average recovery of 100.9% of added s...
The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture of polymers such as pectin...
Sulfacetamide is a sulfonamide that is used mainly as an ophthalmic solution for the treatment of eye infections. It has also been used topically and intravaginally.
In the present work, the spectroscopic and kinetic features of the radical species induced in gamma-irradiated sulfacetamide-sodium (SS) was studied at room and at different temperatures in the dose range of 5–50 kGy by electron spin resonance (ESR) technique with the aim of investigating the p...
The ion solvation behavior of sulfacetamide sodium in water and various volume fractions of ethanol (EtOH) in water in the range of 283 to 313 K, using electrical conductivity principle have been studied. The conductance data were analyzed according to Kraus–Bray and Shedlovsky models of conduc...
Specific, accurate and precise electrochemical method was developed and validated for the determination of sulfacetamide sodium in presence of its co-formulated drug (prednisolone acetate) and its pharmacopoeial impurities. The method was based on fabrication of membrane sensor. The characterist...
To develop more efficacious antibacterial agents, a new type of cationic N-chloramines that contain a pyridinium moiety and a N-chloramine moiety covalently linked via an alkyl chain were prepared and characterized. Preliminary assays indicated that 1) the compound with a propylidene linker exhi...
Organic chloramines can interfere with the measurement of effective combined chlorine in chlorinated water and are potential intermediate products of highly toxic disinfection by-products (DBPs). In order to know more about the degradation and transformation of organic chloramines, a typical org...
This paper is a critical review of current knowledge of organic chloramines in water systems, including their formation, stability, toxicity, analytical methods for detection, and their impact on drinking water treatment and quality. The term organic chloramines may refer to any halogenated orga...
This study compared the degradation efficiency of diatrizoate (DTA) by UV/chlorine and UV/chloramine processes. DTA could be effectively degraded by the UV/chlorine and UV/chloramine processes compared with chlorination and chloramination solely. Although the UV/chlorine process was more sensiti...
Helicobacter pylori (H. pylori) infection triggers inflammatory processes with the consequent production of hypochlorous acid (HOCl), monochloramine (NH2Cl), and protein-derived chloramines. As the therapy for eradicating H. pylori is partially based on the use of tetracycline, we studied the ki...
A model is developed to enable estimation of chloramine demand in full scale drinking water supplies based on chemical and microbiological factors that affect chloramine decay rate via nonlinear regression analysis method. The model is based on organic character (specific ultraviolet absorbance ...
Earlier, we reported on soluble microbial products-mediated chloramine decay in nitrifying waters. However, we neither separated the agent(s) nor identified the factors that enhanced the production of chloramine-decaying soluble microbial products (cSMPs). Experiments were conducted by feeding r...
The kinetic oxidation of mefenamic acid (MEF) and tolfenamic acid (TOL), which therapeutically belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) finds extensive applications in pharmaceuticals. The kinetics of oxidation of MEF and TOL by chloramine-B (CAB) in the presence of...
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