Three new compounds of CoII, NiII and CuII with a flexible dicarboxylate building block 1,3-phenylenediacetate, along with 4,4′-bipyridine, or 4,4′-trimethylenedipyridine co-ligands, with the formula {[Co2(4,4′-bipy)2(1,3-pda)2]·1.5H2O}n (1), {Ni(4,4′-bipy)(1,3-pdaH)2(CH3CH2OH)2}n (2), and ...
Molecular geometry, vibrational wavenumbers and gauge including atomic orbital (GIAO) 13C NMR and 1H NMR chemical shift values of 1,3-phenylenediacetic acid (C10H10O4), in the ground state have been calculated by using ab initio Hartree–Fock (HF) and density functional theory (DFT/B3LYP) method...
Background & AimsThe clinical efficacy of ursodeoxycholic acid (UDCA) in primary biliary cholangitis (PBC) remains subject to debate as definitive randomized controlled trials are lacking. We aimed to determine whether UDCA prolongs liver transplant (LT)-free survival in patients with PBC.
BackgroundLaparoscopic sleeve gastrectomy (LSG) is a definitive solution for morbid obesity and its related co-morbidities. Cholelithiasis is a postoperative complication of LSG. The use of ursodeoxycholic acid (UDCA) after LSG is a proposed solution to reduce the incidence of cholelithiasis.
Obeticholic acid (OCA) is a farnesoid-X-receptor (FXR) ligand, shown effective in reducing steatosis and fibrosis in NASH patients. However, OCA causes major side effects including pruritus, while increases the risk for liver decompensation in cirrhotic patients. Ursodeoxycholic acid (UDCA), is ...
Ursodeoxycholic acid, a secondary bile acid, is used as a drug for the treatment of various liver diseases, the optimal dose comprises the range of 8–10 mg/kg/day. For industrial syntheses, the structural complexity of this bile acid requires the use of an appropriate starting material as well ...
SummaryBackgroundIntrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission. Ursodeoxycholic acid is widely used as a treatment without an ade...
SummaryBackgroundUrsodeoxycholic acid (UDCA) is used for treatment of cholestatic liver diseases and may improve long-term outcome. Although treatment with this hydrophilic bile acid is virtually without side effects, medication adherence might be suboptimal due to patient misconceptions, compro...
Lipopolysaccharide (LPS) from Gram (-) bacteria induces inflammatory cholestasis by impairing the expression/localization of transporters involved in bile formation (e.g., Bsep, Mrp2). Therapeutic options for this disease are lacking. Ursodeoxycholic acid (UDCA) is the first choice therapy in ch...
Ursodeoxycholic acid (UDCA) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. UDCA is also a long-established drug, largely used for the diss...
Various organic compounds can be immobilized on a diamond surface if a chemically active organic functional group, such as an NH2 group, is introduced on the diamond surface. We therefore attempted to introduce an NH2 group on a diamond surface by using chemical reaction of a hydrogenated diamon...
The sulfenylation of ketones having α-hydrogens has been achieved using N-chlorosuccinimide (NCS) under mild reaction conditions to produce α-ketothioethers in excellent yields with high selectivity. The use of NCS makes this method quite simple, convenient and practical.
Single crystals of N-chlorosuccinimide (NCS) were grown by slow evaporation solution growth technique. The grown crystals were confirmed by single crystal X-ray diffraction and FT-IR studies. The theoretical factorial group analysis was carried and the vibrational modes are assigned. The dielect...
Solid additives participate in the dry microwave assisted chlorination reaction of N-chlorosuccinimide with the xylenes affecting both yields and chemoselectivities. Total yields can be increased up to nine times for simple alkylaromatics and chemoselectivities can be altered according to the de...
A rapid and sensitive flow injection chemiluminescence method is described for the determination of sulfide based on the chemiluminescence generated during its reaction with either N-bromosuccinimide (NBS) or N-chlorosuccinimide (NCS) in alkaline medium. The results of investigation of the sensi...
One of the biggest challenges in reverse osmosis membrane process is formation of biofilms on membrane surface (biofouling) which significantly lowers membrane performance and shortens life cycle of the membrane. In an effort to find a more effective biocide to control biofouling, we investigate...
A simple and an efficient procedure for the formation of diaryl sulfides via direct sp2 C–H functionalization have been developed from simple and readily available thiophenols and substituted methoxy benzenes. In this process thiophenols were used as the sulfur source. In this transformation br...
A metal and acid-free electrophilic aromatic chlorination methodology involving catalytic thiourea activation of N-chlorosuccinimide (NCS) is reported herein. Moderate yields and regioselectivities of chlorinated aromatics were obtained using a combination of 1.05–1.15 equiv of NCS and 5 mol % ...
A variety of arenes and heteroarenes are chlorinated in moderate to excellent yields using N-chlorosuccinimide (NCS) under visible-light activated conditions. A screening of known organic dye photocatalysts resulted in the identification of methylene green as the most efficient catalyst to use w...
A novel and convenient way has been developed for the preparation of bromoallenes from propargyl alcohols by the reagent combination of N-bromosuccinimide and dimethyl sulfide. Bromoallenes with high regioselectivity were obtained in a convenient method.
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