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Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Azilsartan CAS 147403-03-0

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Azilsartan

Cas:147403-03-0

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white crystalline powder White crystalline powder Solubility

High quality Azilsartan with best price and good quality cas: 147403-03-0

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Manufacturers

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% factory price in stock Azilsartan powder

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 220.0

Type:Trading Company

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Kono Chem Co.,Ltd

Azilsartan is used as pharmaceutical raw material. Used to cure high blood pressure. Name: Azilsartan CAS No.: 147403-03-0 Content:

CAS:147403-03-0 Azilsartan

Cas:147403-03-0

Min.Order:1 Kilogram

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Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Azilsartan tablets 20mg;40mg

Cas:147403-03-0

Min.Order:1 Gram

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Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:2-8°C Package:1kg/foil bag; 1kg/tin ; 25

Pharmaceutical raw material Azilsartan CAS 147403-03-0 supplied by factory

Cas:147403-03-0

Min.Order:5 Kilogram

FOB Price: $100.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Azilsartan 147403-03-0 ISO Producer

Cas:147403-03-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Azilsartan

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

AZILSARTAN

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Azilsartan 147403-03-0

Cas:147403-03-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Azilsartan

Cas:147403-03-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Azilsartan

Cas:147403-03-0

Min.Order:1 Gram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Azilsartan In stock

Cas:147403-03-0

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Azilsartan Basic information Product Name: Azilsartan Synonyms: AZILSARTAN;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;Tak 536;Unii-F9n

Azilsartan(TA-36)

Cas:147403-03-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 147403-03-0 with best quality

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Azilsartan

Cas:147403-03-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: Azilsartan Synonyms: 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid CAS: 147403-03-0 MF: C25H20N4O5 Appearance: White Powder Storage:Store in cool and dry place, away f

Azilsartan

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Azilsartan Manufacturer 147403-03-0 To Treatment Of High Blood Pressure

Cas:147403-03-0

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

99% Pharmaceutical Raw Materials Azilsartan CAS 147403-03-0 Azilsartan Powder

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

Azilsartan 99% CAS NO.147403-03-0

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Azilsartan CAS: 147403-03-0 MF: C25H20N4O5 MW: 456.45 EINECS: 808-058-6 Mol File: 147403-03-0.mol Azilsartan Structure Azilsartan Chemical Properties Melting point 188 °C(dec.) density 1.42 storage temp.

Azilsartan

Cas:147403-03-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Azilsartan CAS 147403-03-0 For research Use only

Cas:147403-03-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Analgesic and anti-inflammatory, Azilsartan CAS:147403-03-0

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $54.7 / 59.2

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Azilsartan CAS: 147403-03-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Azilsartan CAS: 147403-03-0

Cas:147403-03-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Factory Supply Azilsartan

Cas:147403-03-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Hot sale Azilsartan cas:147403-03-0

Cas:147403-03-0

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Azilsartan

Cas:147403-03-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Azilsartan

Cas:147403-03-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid
1403474-70-3

ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With water; sodium hydroxide at 50℃; for 4h;98.5%
With sodium hydroxide In water at 70 - 75℃; for 1.5h; Temperature;93.4%
With pyrographite; sodium hydroxide In water at 55℃; for 2h; Temperature;91%
C25H19N4O5(1-)*Na(1+)

C25H19N4O5(1-)*Na(1+)

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;97.1%
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
147403-52-9

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Stage #1: methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate With water; sodium hydroxide In methanol at 20℃; for 24h;
Stage #2: With hydrogenchloride In water Product distribution / selectivity;
96.4%
With sodium hydroxide In methanol; water at 20℃; for 24h;96%
With sodium hydroxide In water at 60 - 65℃; Temperature;96.8%
C25H19N4O5(1-)*K(1+)

C25H19N4O5(1-)*K(1+)

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;96.7%
0.36N-NaOH

0.36N-NaOH

pyrographite
7440-44-0

pyrographite

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
147403-52-9

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
96%
0.40N-NaOH

0.40N-NaOH

pyrographite
7440-44-0

pyrographite

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
147403-52-9

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
96%
C25H19N4O5(1-)*Li(1+)

C25H19N4O5(1-)*Li(1+)

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;95.8%
Azilsartan medoxomil
863031-21-4

Azilsartan medoxomil

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With water; sodium hydroxide at 75℃; for 1h; Temperature; Reagent/catalyst;94.84%
With Bis(p-nitrophenyl) phosphate In acetonitrile at 37℃; for 0.0833333h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;
2-ethoxy-1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester di-n-butylamine

2-ethoxy-1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester di-n-butylamine

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 45 - 56℃; for 2.5h;93%
C28H28N4O5

C28H28N4O5

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 40 - 50℃; for 1h; Reagent/catalyst;92.8%
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1397836-41-7

ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate; chloroformic acid ethyl ester With triethylamine In toluene at 30℃; for 2h;
Stage #2: With dmap; water In toluene for 3h; Reflux;
89%
2-ethoxy-1-[[2'-[N'((ethoxycarbonyl)oxy)carbamimidoyl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
147404-82-8

2-ethoxy-1-[[2'-[N'((ethoxycarbonyl)oxy)carbamimidoyl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium hydroxide In water at 40℃; for 2h; Reagent/catalyst; Temperature;87%
Multi-step reaction with 2 steps
1.1: xylene / 1.5 h / Reflux
2.1: sodium hydroxide; water / 1.5 h / 70 °C
2.2: pH 3
View Scheme
Multi-step reaction with 2 steps
1: xylene / 1.5 h / Reflux
2: sodium hydroxide; water / methanol / 24 h / 20 °C
View Scheme
methyl 2-ethoxy-1-((2'-(N'-(phenoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1403477-44-0

methyl 2-ethoxy-1-((2'-(N'-(phenoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With water; sodium hydroxide at 100℃; for 3h; Reagent/catalyst;84%
Multi-step reaction with 2 steps
1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C
2.1: sodium hydroxide; water / 1.5 h / 70 °C
2.2: pH 3
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C
2: sodium hydroxide / water; methanol / 24 h / 20 °C
View Scheme
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
1397836-49-5

1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

phenyl chloroformate
1885-14-9

phenyl chloroformate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 3h; Reagent/catalyst; Solvent;82%
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
1397836-49-5

1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

methyl chloroformate
79-22-1

methyl chloroformate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 3h;80%
carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
147403-65-4

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Stage #1: carbonic acid dimethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With potassium tert-butylate In dimethyl sulfoxide at 100℃; for 4h;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Product distribution / selectivity;
78.9%
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
1397836-49-5

1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

isopropyl chloroformate
108-23-6

isopropyl chloroformate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 3h;78%
carbon dioxide
124-38-9

carbon dioxide

C24H19BrN4O3

C24H19BrN4O3

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at -70℃; Inert atmosphere;71%
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
139481-44-0

methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 55 percent / hydroxylamine / dimethylsulfoxide / 15 h / 75 °C
2: pyridine / dimethylformamide / 0.5 h / 0 °C
3: xylene / 2 h / Heating
4: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 18 h / 25 - 90 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C
3.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C
3.2: 0.5 h / 20 - 25 °C / pH 2 - 3
View Scheme
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 18 h / 90 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 4 h / 20 °C
3: sodium hydroxide; water / 3 h / 50 °C
View Scheme
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
147403-65-4

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / dimethylformamide / 0.5 h / 0 °C
2: xylene / 2 h / Heating
3: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C
2.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C
2.2: 0.5 h / 20 - 25 °C / pH 2 - 3
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane; tetrahydrofuran / 2 h / 20 °C / Cooling with water-ice
2.1: xylene / 1.5 h / Reflux
3.1: sodium hydroxide; water / 1.5 h / 70 °C
3.2: pH 3
View Scheme
C34H40N4O6

C34H40N4O6

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: xylene / 2 h / Heating
2: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1.1: xylene / 2 h / Reflux
2.1: sodium hydroxide; water / 1.5 h / 70 °C
2.2: pH 3
View Scheme
Multi-step reaction with 2 steps
1: xylene / 2 h / Reflux
2: sodium hydroxide; water / methanol / 24 h / 20 °C
View Scheme
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
147403-65-4

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Stage #1: chloroformic acid ethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With pyridine In N,N-dimethyl-formamide for 6h; Inert atmosphere; Cooling with ice-cold bath;
Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 5h;
Stage #3: With hydrogenchloride In water; dimethyl sulfoxide
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1403477-45-1

methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium methylate In tetrahydrofuran at 20℃; for 4h;71.2 %Chromat.
Multi-step reaction with 2 steps
1.1: sodium methylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C
2.1: sodium hydroxide; water / 1.5 h / 70 °C
2.2: pH 3
View Scheme
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C
2.1: pyridine / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Cooling with ice-cold bath
2.2: 5 h / 20 °C
View Scheme
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1403477-45-1

methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

A

azilsartan
147403-03-0

azilsartan

B

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
147403-52-9

methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

Conditions
ConditionsYield
With sodium methylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h;A 11.3 %Chromat.
B 72.7 %Chromat.
With sodium methylate In dimethyl sulfoxide at 20℃; for 4h;A 77.9 %Chromat.
B 17.1 %Chromat.
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1403477-45-1

methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

A

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
147403-65-4

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

B

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h; Product distribution / selectivity;A 7.9 %Chromat.
B 74.8 %Chromat.
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate
1403474-75-8

ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium ethanolate In tetrahydrofuran at 20℃; for 4h;66 %Chromat.
With potassium tert-butylate In tetrahydrofuran at 20℃; for 4h; Product distribution / selectivity;93 %Chromat.
Multi-step reaction with 2 steps
1: dibutylamine / 2 h / 110 - 115 °C
2: sodium hydroxide; water / 1.5 h / 70 - 75 °C
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / 80 °C
2: pyrographite; sodium hydroxide / water / 2 h / 55 °C
View Scheme
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate
1403474-75-8

ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate

A

ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid
1403474-70-3

ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid

B

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
With sodium ethanolate In dimethyl sulfoxide at 20℃; for 4h; Product distribution / selectivity;A 39.3 %Chromat.
B 55.3 %Chromat.
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
139481-41-7

ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C
2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C
3: sodium hydroxide; water / 3 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine; hydroxylamine hydrochloride / dimethyl sulfoxide / 12 h / 75 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C
3: sodium hydroxide / 75 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; hydroxylamine / ethanol; water / 7 h
2: triethylamine / dichloromethane / 2 h / 20 °C
3: ethanol / 15 h / Reflux
4: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C
View Scheme
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
1397836-41-7

ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

azilsartan
147403-03-0

azilsartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C
2: sodium hydroxide; water / 3 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2 h / 20 °C
2: ethanol / 15 h / Reflux
3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2 h / 20 °C
2: ethanol / 15 h / Reflux
3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C
View Scheme
azilsartan
147403-03-0

azilsartan

1-[[2'-(carbamimidoyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid

1-[[2'-(carbamimidoyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With palladium on activated charcoal; ammonium formate; acetic acid In ethanol at 80℃; for 5h; Inert atmosphere;96%
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one
91526-18-0

4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

azilsartan
147403-03-0

azilsartan

Azilsartan medoxomil
863031-21-4

Azilsartan medoxomil

Conditions
ConditionsYield
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 10℃; for 3h;
Stage #2: In N,N-dimethyl acetamide pH=5;
Stage #3: In water; acetone at 35℃; for 2h;
95%
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; p-toluoylsulfonylchloride; potassium carbonate In ISOPROPYLAMIDE at -15 - 25℃;
Stage #2: With hydrogenchloride In ISOPROPYLAMIDE; water for 0.5h; pH=4 - 5;
81%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 8 - 10℃; for 3h;80.1%
3-(hydroxymethyl)-4-phenylfuroxan
135733-30-1

3-(hydroxymethyl)-4-phenylfuroxan

azilsartan
147403-03-0

azilsartan

3-(4-phenyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

3-(4-phenyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Conditions
ConditionsYield
With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 5h; Reagent/catalyst; Solvent; Temperature;94%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 10℃; for 3h;
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one
91526-18-0

4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

azilsartan
147403-03-0

azilsartan

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid dimethylacetamide
1417575-99-5

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid dimethylacetamide

Conditions
ConditionsYield
With dmap; potassium carbonate; p-toluenesulfonyl chloride at 30℃; for 3h; Cooling;86.4%
4-chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7

4-chloromethyl-5-methyl-1,3-dioxol-2-one

azilsartan
147403-03-0

azilsartan

C35H28N4O11

C35H28N4O11

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In N,N-dimethyl acetamide at 35℃; for 3h; Reagent/catalyst; Solvent;85.9%
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
80715-22-6

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

azilsartan
147403-03-0

azilsartan

C35H28N4O11

C35H28N4O11

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h;83%
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide
80841-79-8

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide

azilsartan
147403-03-0

azilsartan

C35H28N4O11

C35H28N4O11

Conditions
ConditionsYield
With sodium carbonate In tetrahydrofuran at 70 - 80℃; for 6h; Reagent/catalyst; Solvent;78.4%
azilsartan
147403-03-0

azilsartan

2-oxo-3-((2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1’-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid

2-oxo-3-((2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1’-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20℃; for 3h; pH=2;60%
With hydrogen bromide In ethanol at 78 - 85℃; for 1h;
tetrahydrofuran
109-99-9

tetrahydrofuran

2-methylimidazole
693-98-1

2-methylimidazole

azilsartan
147403-03-0

azilsartan

C25H20N4O5*C4H6N2*C4H8O

C25H20N4O5*C4H6N2*C4H8O

Conditions
ConditionsYield
In water at 20℃; for 2h;45%
azilsartan
147403-03-0

azilsartan

2-oxo-4-hydroxymethyl-3-methyl-1,2,5-oxadiazol
183537-57-7

2-oxo-4-hydroxymethyl-3-methyl-1,2,5-oxadiazol

4-(3-methyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

4-(3-methyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Conditions
ConditionsYield
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h;44.4%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h;44.4%
2-methylimidazole
693-98-1

2-methylimidazole

acetone
67-64-1

acetone

azilsartan
147403-03-0

azilsartan

C25H20N4O5*C4H6N2*C3H6O

C25H20N4O5*C4H6N2*C3H6O

Conditions
ConditionsYield
In water at 20℃; for 2h;44%

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