Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryHunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant
Items Standard Result Appearance White or off-white crystalline powder White crystalline powder Solubility
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Manufacturers
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $20.0 / 220.0
Type:Trading Company
inquiryAzilsartan is used as pharmaceutical raw material. Used to cure high blood pressure. Name: Azilsartan CAS No.: 147403-03-0 Content:
We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:2-8°C Package:1kg/foil bag; 1kg/tin ; 25
Cas:147403-03-0
Min.Order:5 Kilogram
FOB Price: $100.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:147403-03-0
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:147403-03-0
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:147403-03-0
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Trading Company
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:147403-03-0
Min.Order:1 Gram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:147403-03-0
Min.Order:1 Gram
FOB Price: $1000.0 / 1300.0
Type:Trading Company
inquiryAzilsartan Basic information Product Name: Azilsartan Synonyms: AZILSARTAN;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;Tak 536;Unii-F9n
Cas:147403-03-0
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
Name: Azilsartan Synonyms: 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid CAS: 147403-03-0 MF: C25H20N4O5 Appearance: White Powder Storage:Store in cool and dry place, away f
Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:147403-03-0
Min.Order:10 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryProduct Name: Azilsartan CAS: 147403-03-0 MF: C25H20N4O5 MW: 456.45 EINECS: 808-058-6 Mol File: 147403-03-0.mol Azilsartan Structure Azilsartan Chemical Properties Melting point 188 °C(dec.) density 1.42 storage temp.
About Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:147403-03-0
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $54.7 / 59.2
Type:Trading Company
inquiryAzilsartan CAS: 147403-03-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:147403-03-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:147403-03-0
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
Cas:147403-03-0
Min.Order:25 Gram
FOB Price: $90.0 / 100.0
Type:Trading Company
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:147403-03-0
Min.Order:1 Kilogram
FOB Price: $10.0 / 20.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid
azilsartan
Conditions | Yield |
---|---|
With water; sodium hydroxide at 50℃; for 4h; | 98.5% |
With sodium hydroxide In water at 70 - 75℃; for 1.5h; Temperature; | 93.4% |
With pyrographite; sodium hydroxide In water at 55℃; for 2h; Temperature; | 91% |
azilsartan
Conditions | Yield |
---|---|
With citric acid In water at 5℃; pH=5; Reagent/catalyst; | 97.1% |
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Stage #1: methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate With water; sodium hydroxide In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In water Product distribution / selectivity; | 96.4% |
With sodium hydroxide In methanol; water at 20℃; for 24h; | 96% |
With sodium hydroxide In water at 60 - 65℃; Temperature; | 96.8% |
azilsartan
Conditions | Yield |
---|---|
With citric acid In water at 5℃; pH=5; Reagent/catalyst; | 96.7% |
pyrographite
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
96% |
pyrographite
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
96% |
azilsartan
Conditions | Yield |
---|---|
With citric acid In water at 5℃; pH=5; Reagent/catalyst; | 95.8% |
Azilsartan medoxomil
azilsartan
Conditions | Yield |
---|---|
With water; sodium hydroxide at 75℃; for 1h; Temperature; Reagent/catalyst; | 94.84% |
With Bis(p-nitrophenyl) phosphate In acetonitrile at 37℃; for 0.0833333h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction; |
azilsartan
Conditions | Yield |
---|---|
With water; sodium hydroxide In ethanol at 45 - 56℃; for 2.5h; | 93% |
azilsartan
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 40 - 50℃; for 1h; Reagent/catalyst; | 92.8% |
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
chloroformic acid ethyl ester
azilsartan
Conditions | Yield |
---|---|
Stage #1: ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate; chloroformic acid ethyl ester With triethylamine In toluene at 30℃; for 2h; Stage #2: With dmap; water In toluene for 3h; Reflux; | 89% |
2-ethoxy-1-[[2'-[N'((ethoxycarbonyl)oxy)carbamimidoyl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester
azilsartan
Conditions | Yield |
---|---|
With sodium hydroxide In water at 40℃; for 2h; Reagent/catalyst; Temperature; | 87% |
Multi-step reaction with 2 steps 1.1: xylene / 1.5 h / Reflux 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme | |
Multi-step reaction with 2 steps 1: xylene / 1.5 h / Reflux 2: sodium hydroxide; water / methanol / 24 h / 20 °C View Scheme |
methyl 2-ethoxy-1-((2'-(N'-(phenoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
With water; sodium hydroxide at 100℃; for 3h; Reagent/catalyst; | 84% |
Multi-step reaction with 2 steps 1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C 2: sodium hydroxide / water; methanol / 24 h / 20 °C View Scheme |
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
phenyl chloroformate
azilsartan
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; for 3h; Reagent/catalyst; Solvent; | 82% |
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
methyl chloroformate
azilsartan
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; for 3h; | 80% |
carbonic acid dimethyl ester
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Stage #1: carbonic acid dimethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With potassium tert-butylate In dimethyl sulfoxide at 100℃; for 4h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Product distribution / selectivity; | 78.9% |
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid
isopropyl chloroformate
azilsartan
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; for 3h; | 78% |
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -70℃; Inert atmosphere; | 71% |
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 55 percent / hydroxylamine / dimethylsulfoxide / 15 h / 75 °C 2: pyridine / dimethylformamide / 0.5 h / 0 °C 3: xylene / 2 h / Heating 4: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 18 h / 25 - 90 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C 3.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 3.2: 0.5 h / 20 - 25 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 18 h / 90 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 4 h / 20 °C 3: sodium hydroxide; water / 3 h / 50 °C View Scheme |
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: pyridine / dimethylformamide / 0.5 h / 0 °C 2: xylene / 2 h / Heating 3: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C 2.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 2.2: 0.5 h / 20 - 25 °C / pH 2 - 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane; tetrahydrofuran / 2 h / 20 °C / Cooling with water-ice 2.1: xylene / 1.5 h / Reflux 3.1: sodium hydroxide; water / 1.5 h / 70 °C 3.2: pH 3 View Scheme |
azilsartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: xylene / 2 h / Heating 2: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: xylene / 2 h / Reflux 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme | |
Multi-step reaction with 2 steps 1: xylene / 2 h / Reflux 2: sodium hydroxide; water / methanol / 24 h / 20 °C View Scheme |
chloroformic acid ethyl ester
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Stage #1: chloroformic acid ethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With pyridine In N,N-dimethyl-formamide for 6h; Inert atmosphere; Cooling with ice-cold bath; Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 5h; Stage #3: With hydrogenchloride In water; dimethyl sulfoxide |
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
With sodium methylate In tetrahydrofuran at 20℃; for 4h; | 71.2 %Chromat. |
Multi-step reaction with 2 steps 1.1: sodium methylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme | |
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C 2.1: pyridine / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Cooling with ice-cold bath 2.2: 5 h / 20 °C View Scheme |
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
A
azilsartan
B
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate
Conditions | Yield |
---|---|
With sodium methylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h; | A 11.3 %Chromat. B 72.7 %Chromat. |
With sodium methylate In dimethyl sulfoxide at 20℃; for 4h; | A 77.9 %Chromat. B 17.1 %Chromat. |
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
A
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
B
azilsartan
Conditions | Yield |
---|---|
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h; Product distribution / selectivity; | A 7.9 %Chromat. B 74.8 %Chromat. |
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
With sodium ethanolate In tetrahydrofuran at 20℃; for 4h; | 66 %Chromat. |
With potassium tert-butylate In tetrahydrofuran at 20℃; for 4h; Product distribution / selectivity; | 93 %Chromat. |
Multi-step reaction with 2 steps 1: dibutylamine / 2 h / 110 - 115 °C 2: sodium hydroxide; water / 1.5 h / 70 - 75 °C View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / 80 °C 2: pyrographite; sodium hydroxide / water / 2 h / 55 °C View Scheme |
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate
A
ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid
B
azilsartan
Conditions | Yield |
---|---|
With sodium ethanolate In dimethyl sulfoxide at 20℃; for 4h; Product distribution / selectivity; | A 39.3 %Chromat. B 55.3 %Chromat. |
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 3: sodium hydroxide; water / 3 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine; hydroxylamine hydrochloride / dimethyl sulfoxide / 12 h / 75 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C 3: sodium hydroxide / 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine; hydroxylamine / ethanol; water / 7 h 2: triethylamine / dichloromethane / 2 h / 20 °C 3: ethanol / 15 h / Reflux 4: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme |
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
azilsartan
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 2: sodium hydroxide; water / 3 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: ethanol / 15 h / Reflux 3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: ethanol / 15 h / Reflux 3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme |
azilsartan
Conditions | Yield |
---|---|
With palladium on activated charcoal; ammonium formate; acetic acid In ethanol at 80℃; for 5h; Inert atmosphere; | 96% |
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one
azilsartan
Azilsartan medoxomil
Conditions | Yield |
---|---|
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 10℃; for 3h; Stage #2: In N,N-dimethyl acetamide pH=5; Stage #3: In water; acetone at 35℃; for 2h; | 95% |
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; p-toluoylsulfonylchloride; potassium carbonate In ISOPROPYLAMIDE at -15 - 25℃; Stage #2: With hydrogenchloride In ISOPROPYLAMIDE; water for 0.5h; pH=4 - 5; | 81% |
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 8 - 10℃; for 3h; | 80.1% |
3-(hydroxymethyl)-4-phenylfuroxan
azilsartan
Conditions | Yield |
---|---|
With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 5h; Reagent/catalyst; Solvent; Temperature; | 94% |
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 10℃; for 3h; |
N,N-dimethyl acetamide
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one
azilsartan
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid dimethylacetamide
Conditions | Yield |
---|---|
With dmap; potassium carbonate; p-toluenesulfonyl chloride at 30℃; for 3h; Cooling; | 86.4% |
Conditions | Yield |
---|---|
With sodium carbonate; sodium iodide In N,N-dimethyl acetamide at 35℃; for 3h; Reagent/catalyst; Solvent; | 85.9% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h; | 83% |
Conditions | Yield |
---|---|
With sodium carbonate In tetrahydrofuran at 70 - 80℃; for 6h; Reagent/catalyst; Solvent; | 78.4% |
azilsartan
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20℃; for 3h; pH=2; | 60% |
With hydrogen bromide In ethanol at 78 - 85℃; for 1h; |
Conditions | Yield |
---|---|
In water at 20℃; for 2h; | 45% |
azilsartan
2-oxo-4-hydroxymethyl-3-methyl-1,2,5-oxadiazol
Conditions | Yield |
---|---|
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h; | 44.4% |
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h; | 44.4% |
Conditions | Yield |
---|---|
In water at 20℃; for 2h; | 44% |
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