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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Ursodeoxycholic acid Manufacturer/High quality/Best price/In stock

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

UDCA/Ursodeoxycholic acid CAS 128-13-2 supply with high purity and factory price CAS NO.128-13-2

Cas:128-13-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Brief Description Product name Ursodeoxycholic acid Synonyms Ursic acid 34784-46-7

UDCA/Ursodeoxycholic acid CAS 128-13-2 supply with high purity and factory price

Cas:128-13-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Ursodeoxycholic acid 128-13-2

Cas:128-13-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance White powder Conform with CP2005 Rotation +59.0。

High quality Ursodeoxycholic acid with best price and good quality cas:128-13-2

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $400.0 / 480.0

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good serv

Ursodeoxycholic acid manufacture supply

Cas:128-13-2

Min.Order:1 Gram

FOB Price: $10.0

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ursodeoxycholic Acid (Udca) supplier in China

Cas:128-13-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

About us We are a Professionally Managed Biotech Company exclusively into the manufacturing, Marketing and Exporting of Plant Extracts and Health Care Products.There are 15 experts in our research team. We insist in innovation an

Ursodeoxycholic acid

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $800.0 / 1000.0

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ursodeoxycholic acid Manufacturer/High quality/Best price/In stock CAS NO.128-13-2

Cas:128-13-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Ursodeoxycholic acid CAS 128-13-2 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distri

Ursodeoxycholic acid CAS 128-13-2

Cas:128-13-2

Min.Order:25 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

TNJ is a chemical company since 2001. Our specialization, your Confidence ! We keep committing to meet the needs of both market and customers with our innovative technology, high stable quality products and excellent service. We always combine econ

Hot sale UDCA( Ursodeoxycholic Acid)

Cas:128-13-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Ursodeoxycholic acid CAS No.:128-13-2 Name: Ursodeoxycholic acid Synonyms: 3,7-Dihydroxycholan-24-oic acid; 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid; Ursodiol Molecular Structure Molecular Formula:

High purity Ursodeoxycholic acid CAS No.:128-13-2

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ursodeoxycholic acid

Cas:128-13-2

Min.Order:1

Negotiable

Type:Other

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HANGZHOU CLAKE BIOTECH CO.,LTD

1. GMP AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum Application:active pharmaceutical ingredient Transportation:sea/air both ok Port:any port

Ursodeoxycholic acid

Cas:128-13-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Ursodeoxycholic acid 128-13-2 ISO Producer

Cas:128-13-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Ursodeoxycholic acid

Cas:128-13-2

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Ursodeoxycholic acid CAS 128-13-2 In stock

Cas:128-13-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed prod

Ursodeoxycholic acid

Cas:128-13-2

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hubei DiBo chemical co., LTD

Name:Ursodeoxycholic acid CAS no:128-13-2 Grade:Medical, scientific research and export Molecular formula:C24H39O4 Molecular weight:391.5646 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabili

Ursodeoxycholic acid/cas:128-13-2/high quality/Ursodeoxycholic acid material

Cas:128-13-2

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

128-13-2 Ursodeoxycholic acid

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Ursodiol CAS: 128-13-2 Factory Supplier

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 128-13-2 with best quality

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Ursodeoxycholic acid/ LIDE PHARMA- Factory supply / Best price

Cas:128-13-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Ursodeoxycholic acid CAS: 128-13-2 Product Name: Ursodeoxycholic acid Synonyms: 7BETA-HYDROXYLITHOCHOLIC ACID;6BETA-CHOLANIC ACID-3A,7BETA-DIOL;(6-BETA)-CHOLANIC ACID-(3-ALPHA)-(7-BETA)-DIOL;3A,7B-DIHYDROXY-5B-CHOLAN-24-O

Ursodeoxycholic acid

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ursodeoxycholic acid 128-13-2

Cas:128-13-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Factory Supply Ursodeoxycholic acid / Tauroursodiol / UDCA

Cas:128-13-2

Min.Order:10 Gram

FOB Price: $3.2

Type:Trading Company

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refrigerator

Ursodiol Ursodeoxycholic acid In stock 99% EP USP 128-13-2 cas

Cas:128-13-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

API Ursodeoxycholic Acid Powder CAS 128-13-2

Cas:128-13-2

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Ursodeoxycholic acid CAS:128-13-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

Ursodeoxycholic acid CAS:128-13-2

Cas:128-13-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester
10538-55-3

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With methanol; sodium methylate at 25℃;99%
With water; sodium hydroxide at 97℃; for 2h; Large scale;49.1 kg
With water; sodium hydroxide at 120℃; for 12h;20.7 g
With water; sodium hydroxide at 120℃; for 12h; Time;29.4 g
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With glucose dehydrogenase; D-Glucose; NADPH; 7β-hydroxysteroid dehydrogenase In aq. phosphate buffer at 30℃; for 1h; pH=8; Concentration; pH-value; Enzymatic reaction;98%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In aq. phosphate buffer at 37℃; pH=7;93%
With potassium borohydride; potassium tert-butylate In isopropyl alcohol at 40℃; for 24h;92%
potassium ter.butylate

potassium ter.butylate

potassium 3,7-dioxo-5beta-cholanate

potassium 3,7-dioxo-5beta-cholanate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With hydrogenchloride; hydrogen; aluminum nickel In water98%
C24H36O4

C24H36O4

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: C24H36O4 With potassium tert-butylate In tert-butyl alcohol for 0.5h;
Stage #2: With palladium 10% on activated carbon; hydrogen In tert-butyl alcohol at 80℃; under 3750.38 Torr; for 12h; Solvent; Reagent/catalyst; Temperature;
96%
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: 7-Ketolithocholic acid With potassium tert-butylate; palladium(II) hydroxide; potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h;
Stage #2: With hydrogen In isopropyl alcohol at 40 - 80℃; Reagent/catalyst; Temperature;
A n/a
B 95%
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 20℃; for 0.5h; var. reducing agents;A 94%
B 2%
With potassium In tert-butyl alcohol for 0.5h; Heating; var. reducing agents;A 6%
B 94%
(3α,5β,7β)-7-hydroxy-3-[(4-nitrobenzoyl)oxy]-5-cholen-24-acid methyl ester

(3α,5β,7β)-7-hydroxy-3-[(4-nitrobenzoyl)oxy]-5-cholen-24-acid methyl ester

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; for 6h;94%
3α-hydroxy-7-keto-5β-chol-11-en-24-oic acid

3α-hydroxy-7-keto-5β-chol-11-en-24-oic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With potassium borohydride; potassium tert-butylate; hydrogen at 40℃; under 30003 Torr; for 24h;93%
With potassium borohydride; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 30003 Torr; for 24h; Autoclave;93%
With potassium borohydride; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 30003 Torr; for 24h;93%
(E)-7-hydroxy-3-oxo-4,6,22-choladienoic acid ethyl ester

(E)-7-hydroxy-3-oxo-4,6,22-choladienoic acid ethyl ester

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: (E)-7-hydroxy-3-oxo-4,6,22-choladienoic acid ethyl ester In 2-methyltetrahydrofuran at 90℃; under 30003 Torr; for 24h; Autoclave;
Stage #2: With sodium t-butanolate In 2-methyltetrahydrofuran; isopropyl alcohol at 90℃; under 30003 Torr; for 24h; Solvent; Reagent/catalyst; Temperature; Autoclave;
87%
C26H36O4

C26H36O4

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: C26H36O4 With hydrogen In 2-methyltetrahydrofuran at 90℃; under 30003 Torr; for 24h; Autoclave;
Stage #2: With sodium t-butanolate In 2-methyltetrahydrofuran; isopropyl alcohol at 90℃; for 24h; Solvent; Reagent/catalyst; Temperature;
87%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With NAD In methanol; aq. phosphate buffer at 25℃; for 24h; pH=8;86%
With 7β-hydroxysteroid dehydrogenase; Sepharose-CL6B; TEA; nicotinamide adenine dinucleotide In water at 20℃; for 120h;75%
Multi-step reaction with 2 steps
1: potassium phosphate, pyruvate, dithiothreitol, NAD / H2O / Ambient temperature; lactic dehydrogenase, 7α-hydroxysteroid dehydrogenase
2: potassium phosphate, glucose, dithiothreitol, NADP / H2O / glucose dehydrogenase, 7β-hydroxysteroid dehydrogenase
View Scheme
Lithocholic acid
434-13-9

Lithocholic acid

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

3-keto-7β-hydroxy-5β-cholan-24-oic acid
77060-26-5

3-keto-7β-hydroxy-5β-cholan-24-oic acid

Conditions
ConditionsYield
With Gibberella zeae VKM F-2600 extract In methanol; aq. phosphate buffer at 29℃; for 122h; pH=7; Microbiological reaction;A 83%
B n/a
3α,7β-dihydroxy-12-oxo-5β-cholane-24-oic acid
81873-91-8

3α,7β-dihydroxy-12-oxo-5β-cholane-24-oic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With hydrazine hydrate; potassium hydroxide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 110 - 135℃; Wolf-Kishner reduction;82%
methyl 3α-acetoxy-7-keto-5β-chol-11-enoate

methyl 3α-acetoxy-7-keto-5β-chol-11-enoate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With potassium borohydride; potassium tert-butylate; hydrogen at 40℃; under 30003 Torr; for 24h;80%
Multi-step reaction with 2 steps
1: sodium hydroxide; water / methanol; tetrahydrofuran / 4 h / Reflux; Inert atmosphere
2: potassium tert-butylate; potassium borohydride; hydrogen / isopropyl alcohol / 24 h / 40 °C / 30003 Torr / Autoclave
View Scheme
7-ketochenodeoxycholic acid sodium salt

7-ketochenodeoxycholic acid sodium salt

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With 1,4-dihydronicotinamide adenine dinucleotide; 7β-hydroxysteroid dehydrogenase; 2-hydroxyethanethiol; ethylenediaminetetraacetic acid In phosphate buffer at 20℃; for 48h; pH=7;75%
ethyl 3α-benzoyloxy-7β-hydroxy-chol-5-en-24-oate

ethyl 3α-benzoyloxy-7β-hydroxy-chol-5-en-24-oate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Stage #1: ethyl 3α-benzoyloxy-7β-hydroxy-chol-5-en-24-oate With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol under 2844.39 Torr; for 24h;
Stage #2: With methanol; sodium hydroxide for 18h; Reflux;
71%
methyl 3,7-dioxocholan-24-oate
7753-72-2

methyl 3,7-dioxocholan-24-oate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With ammonia; lithium In tetrahydrofuran; methanol at -50℃; for 1h;68%
methyl 3α-acetoxy-7-oxo-5β-cholan-24-oate
10452-65-0

methyl 3α-acetoxy-7-oxo-5β-cholan-24-oate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With sodium In butan-1-ol at 20 - 60℃; for 2.25h; Inert atmosphere;62%
chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

Conditions
ConditionsYield
With air; Xanthomonas maltophilia CBS 827.97 In sodium hydroxide at 30℃; for 4h; pH=8; epimerisation;A 27%
B 23%
With Xanthomonas maltophilia In water at 30℃; for 24h; pH=8; anaerobic;A 27%
B 23%
3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With aluminum isopropoxide; isopropyl alcohol
7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

sodium ethanolate
141-52-6

sodium ethanolate

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
at 200℃;
3,7-diketocholanic acid
859-97-2

3,7-diketocholanic acid

aluminum isopropoxide
555-31-7

aluminum isopropoxide

isopropyl alcohol
67-63-0

isopropyl alcohol

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

methyl 3-O-acetyl-7-O-mesylchenodeoxycholate
81857-23-0

methyl 3-O-acetyl-7-O-mesylchenodeoxycholate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With potassium superoxide; 18-crown-6 ether In dimethyl sulfoxide for 3h; Yield given;
6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin ursodeoxycholic acid 1:1 complex

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin ursodeoxycholic acid 1:1 complex

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin ursodeoxycholic acid 1:1 complex

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin ursodeoxycholic acid 1:1 complex

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
hydrogenchloride
7647-01-0

hydrogenchloride

7-Ketolithocholic acid
4651-67-6

7-Ketolithocholic acid

acetic acid
64-19-7

acetic acid

platinum

platinum

A

chenodeoxycholic acid
474-25-9

chenodeoxycholic acid

B

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Hydrogenation;
[3H] Sodium glycoursodeoxycholate
92411-07-9

[3H] Sodium glycoursodeoxycholate

A

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

B

glycine
56-40-6

glycine

Conditions
ConditionsYield
With chloylglycine hydrolase In phosphate buffer at 84℃; for 0.0833333h;
glycochenodeoxycholic acid sodium salt
16564-43-5

glycochenodeoxycholic acid sodium salt

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent Chromat. / chloylglycine hydrolase; β-mercaptoethanol; EDTA / aq. phosphate buffer / 3 h / 20 °C / pH 8
2: 75 percent / Sepharose-CL6B; 7β-hydroxysteroid dehydrogenase; TEA / NAD(+) / H2O / 120 h / 20 °C
View Scheme
sodium taurochenodeoxycholate
6009-98-9

sodium taurochenodeoxycholate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent Chromat. / chloylglycine hydrolase; β-mercaptoethanol; EDTA / aq. phosphate buffer / 0.33 h / 20 °C / pH 8
2: 75 percent / Sepharose-CL6B; 7β-hydroxysteroid dehydrogenase; TEA / NAD(+) / H2O / 120 h / 20 °C
View Scheme
methyl 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate
10538-64-4

methyl 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oate

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 52 percent / acetic acid / 12 h / Ambient temperature
2: 57 percent / NaBH4 / acetic acid / 3 h / Ambient temperature
3: pyridine / benzene
4: pyridine / Ambient temperature
5: KO2/18-crown-6 ether / dimethylsulfoxide / 3 h
View Scheme
N-Methyltaurine
107-68-6

N-Methyltaurine

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

3α,7β-dihydroxy-5β-cholan-24-oyl-N-methyltaurine

3α,7β-dihydroxy-5β-cholan-24-oyl-N-methyltaurine

Conditions
ConditionsYield
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In N,N-dimethyl-formamide at 20℃; for 1h;100%
methanol
67-56-1

methanol

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester
10538-55-3

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 2.5h; Reflux;98%
With sulfuric acid at 50℃; for 3h;97%
With toluene-4-sulfonic acid at 65℃; for 2.5h;97%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

acetic anhydride
108-24-7

acetic anhydride

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
6533-77-3

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-diacetoxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Conditions
ConditionsYield
In pyridine at 20℃; for 12h;98%
With dmap In dichloromethane at 20℃; for 1h; Inert atmosphere;95%
With pyridine at 20℃; Inert atmosphere;92%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

4-hydroxypropiophenone
70-70-2

4-hydroxypropiophenone

C33H48O5

C33H48O5

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 2h; Temperature; Concentration;97.3%
formic acid
64-18-6

formic acid

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
6058-15-7, 6159-50-8

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-bis(formyloxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Conditions
ConditionsYield
at 55℃; for 20h;96%
With perchloric acid96%
1) 65 deg C, 4 h, 2) 25 deg C, 20 h;95%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

ferric ursodeoxycholate

ferric ursodeoxycholate

Conditions
ConditionsYield
With iron(III) chloride; sodium hydroxide In water at 35℃; pH=8;95%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

tauroursodeoxycholic acid sodium salt
35807-85-3

tauroursodeoxycholic acid sodium salt

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; acetonitrile; tert-butyl alcohol at 20 - 80℃;95%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

benzyl bromide
100-39-0

benzyl bromide

benzyl 3α,7β-dihydroxy-5β-cholan-24-oate
111992-93-9

benzyl 3α,7β-dihydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 80℃; for 3h;95%
With potassium carbonate In acetonitrile at 80℃; for 3h;95%
Stage #1: ursodeoxycholic acid With potassium hydrogencarbonate In N,N-dimethyl-formamide for 0.333333h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide for 48h;
95%
With potassium carbonate In acetonitrile at 80℃; for 3h;95%
With caesium carbonate In acetonitrile for 4h; Reflux;82%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

Conditions
ConditionsYield
With samarium diiodide; water; triethylamine In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;94%
With lithium aluminium tetrahydride
Multi-step reaction with 2 steps
1: thionyl chloride / 3.5 h / 20 °C / Reflux
2: sodium tetrahydroborate; ethanol / 20 °C
View Scheme
ethanol
64-17-5

ethanol

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

ethyl 3α,7β-dihydroxy-5β-cholan-24-oate
69519-36-4

ethyl 3α,7β-dihydroxy-5β-cholan-24-oate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 24h; Ambient temperature;93%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

2-aminoethanoic acid hydrochloride
6000-43-7

2-aminoethanoic acid hydrochloride

glycine ursodeoxycholic acid ethyl ester
115488-03-4

glycine ursodeoxycholic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In acetone for 12h; Solvent; Time; Reflux;93%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

acetyl chloride
75-36-5

acetyl chloride

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester
10538-55-3

3α,7β-dihydroxy-5β-cholan-24-oic acid methyl ester

Conditions
ConditionsYield
In methanol at 0 - 20℃; for 6h;92%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

A

3,7-bis(sulfooxy)ursodeoxycholic acid
88426-32-8

3,7-bis(sulfooxy)ursodeoxycholic acid

B

7-hydroxy-3-(sulfooxy)-(3α,5β,7β)-cholan-24-oic acid
59132-32-0, 64520-49-6, 68780-68-7, 68833-02-3, 124815-69-6, 68780-73-4

7-hydroxy-3-(sulfooxy)-(3α,5β,7β)-cholan-24-oic acid

C

7-(sulfooxy)ursodeoxycholic acid
74723-14-1

7-(sulfooxy)ursodeoxycholic acid

Conditions
ConditionsYield
With pyridine; sulfur trioxide pyridine complex at 0 - 20℃; for 0.166667h; other temperatures, other times, other reagent ratio;A 91.9%
B 4.1%
C 2.6%
With pyridine; sulfur trioxide pyridine complex at -5℃; for 0.166667h; Product distribution; other temperatures, other reaction times, other reagent ratio;A 25%
B 31.2%
C 25%
With pyridine; sulfur trioxide pyridine complex at -5℃; for 0.166667h; other temperatures, other times, other reagent ratio;A 25%
B 31.2%
C 25%
With pyridine; sulfur trioxide pyridine complex at -5℃; for 0.166667h; other temperatures, other times, other reagent ratio;A 25%
B 31.2%
C 25%
trimethyl-sulfo-ammonium betaine
63147-26-2

trimethyl-sulfo-ammonium betaine

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

ursodeoxycholic acid di-trimethylammonium 3,7-disulfate

ursodeoxycholic acid di-trimethylammonium 3,7-disulfate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 40 - 90℃;91.6%
Conditions
ConditionsYield
Stage #1: ursodeoxycholic acid; glycine With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; acetonitrile; tert-butyl alcohol at 20 - 80℃;
Stage #2: With hydrogenchloride In water pH=2;
91%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

N1<(3α,5β,7β)3,7-dihydroxy-24-oxo-cholan-24-yl>N4 methyl-piperazine
86678-72-0

N1<(3α,5β,7β)3,7-dihydroxy-24-oxo-cholan-24-yl>N4 methyl-piperazine

Conditions
ConditionsYield
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 10 min then rt., 1 h;90%
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

3-keto-7β-hydroxy-5β-cholan-24-oic acid
77060-26-5

3-keto-7β-hydroxy-5β-cholan-24-oic acid

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; D-glucose; Pseudomonas paucimobilis; yeast extracxt; peptone In water at 28℃; for 24h;90%
Multi-step reaction with 4 steps
1: triethylamine; DMAP / ethyl acetate / 10 h / Heating
2: 5percent NaOH / methanol / 1 h
3: Jones' reagent / acetone / 0.08 h
4: 95 percent / 20percent NaOH / 1 h / Heating
View Scheme
ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

arabinosyl cytosine
147-94-4

arabinosyl cytosine

(4R)-N-(1-((3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

(4R)-N-(1-((3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

Conditions
ConditionsYield
Stage #1: ursodeoxycholic acid With triethylamine; isobutyl chloroformate In N,N-dimethyl-formamide at -15℃; for 0.25h; Inert atmosphere;
Stage #2: arabinosyl cytosine With triethylamine In N,N-dimethyl-formamide at -15 - 20℃; for 0.5h; Inert atmosphere;
87%
Stage #1: ursodeoxycholic acid With triethylamine; isobutyl chloroformate In N,N-dimethyl-formamide at -15℃; for 0.0833333h;
Stage #2: arabinosyl cytosine With triethylamine In N,N-dimethyl-formamide at -15 - 20℃; for 2.5h;
pyrrolidine
123-75-1

pyrrolidine

ursodeoxycholic acid
128-13-2

ursodeoxycholic acid

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-(pyrrolidin-1-yl)pentan-1-one

(R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-(pyrrolidin-1-yl)pentan-1-one

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 16h;87%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 16h;87%
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