Azilsartan supplier | CasNO.147403-03-0

Name
Azilsartan
EINECS 808-058-6
CAS No. 147403-03-0
Article Data35
CAS DataBase
Density 1.42 cm³
Solubility
Melting Point 188 °C(dec.)
Formula C₂₅H₂₀N₄O₅
Boiling Point
Molecular Weight 456.458
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms see 1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol- 3-yl)[1,1'-biphenyl]-4-yl]methyl]-2- ethoxy-;TAK 536;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;
PSA 123.24000
LogP 4.19180

Synthetic route

: 1403474-70-3
ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide at 50℃; for 4h;	98.5%
With sodium hydroxide In water at 70 - 75℃; for 1.5h; Temperature;	93.4%
With pyrographite; sodium hydroxide In water at 55℃; for 2h; Temperature;	91%

: C25H19N4O5(1-)*Na(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	97.1%

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Stage #1: methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate With water; sodium hydroxide In methanol at 20℃; for 24h; Stage #2: With hydrogenchloride In water Product distribution / selectivity;	96.4%
With sodium hydroxide In methanol; water at 20℃; for 24h;	96%
With sodium hydroxide In water at 60 - 65℃; Temperature;	96.8%

: C25H19N4O5(1-)*K(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	96.7%

0.36N-NaOH: 0.36N-NaOH

: 7440-44-0
pyrographite

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
	96%

...Expand

0.40N-NaOH: 0.40N-NaOH

: 7440-44-0
pyrographite

: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
	96%

...Expand

: C25H19N4O5(1-)*Li(1+)

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With citric acid In water at 5℃; pH=5; Reagent/catalyst;	95.8%

: 863031-21-4
Azilsartan medoxomil

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide at 75℃; for 1h; Temperature; Reagent/catalyst;	94.84%
With Bis(p-nitrophenyl) phosphate In acetonitrile at 37℃; for 0.0833333h; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 2-ethoxy-1-[[2′-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid ethyl ester di-n-butylamine

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide In ethanol at 45 - 56℃; for 2.5h;	93%

: C28H28N4O5

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 40 - 50℃; for 1h; Reagent/catalyst;	92.8%

: 1397836-41-7
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 541-41-3
chloroformic acid ethyl ester

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Stage #1: ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate; chloroformic acid ethyl ester With triethylamine In toluene at 30℃; for 2h; Stage #2: With dmap; water In toluene for 3h; Reflux;	89%

: 147404-82-8
2-ethoxy-1-[[2'-[N'((ethoxycarbonyl)oxy)carbamimidoyl][1,1-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid methyl ester

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In water at 40℃; for 2h; Reagent/catalyst; Temperature;	87%
Multi-step reaction with 2 steps 1.1: xylene / 1.5 h / Reflux 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme
Multi-step reaction with 2 steps 1: xylene / 1.5 h / Reflux 2: sodium hydroxide; water / methanol / 24 h / 20 °C View Scheme

: 1403477-44-0
methyl 2-ethoxy-1-((2'-(N'-(phenoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With water; sodium hydroxide at 100℃; for 3h; Reagent/catalyst;	84%
Multi-step reaction with 2 steps 1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 20 °C 2: sodium hydroxide / water; methanol / 24 h / 20 °C View Scheme

: 1397836-49-5
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

: 1885-14-9
phenyl chloroformate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 3h; Reagent/catalyst; Solvent;	82%

: 1397836-49-5
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

: 79-22-1
methyl chloroformate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 3h;	80%

: 616-38-6
carbonic acid dimethyl ester

: 147403-65-4
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Stage #1: carbonic acid dimethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With potassium tert-butylate In dimethyl sulfoxide at 100℃; for 4h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide Product distribution / selectivity;	78.9%

: 1397836-49-5
1-[(2'-(N'-hydroxycarbamimidoyl)[1,1'-biphenyl]-4-yl)methyl]-2-ethoxy-1H-1,3-benzodiazole-7-carboxylic acid

: 108-23-6
isopropyl chloroformate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium hydroxide In water at 100℃; for 3h;	78%

: 124-38-9
carbon dioxide

: C24H19BrN4O3

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran at -70℃; Inert atmosphere;	71%

: 139481-44-0
methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 55 percent / hydroxylamine / dimethylsulfoxide / 15 h / 75 °C 2: pyridine / dimethylformamide / 0.5 h / 0 °C 3: xylene / 2 h / Heating 4: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme
Multi-step reaction with 3 steps 1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / dimethyl sulfoxide / 18 h / 25 - 90 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C 3.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 3.2: 0.5 h / 20 - 25 °C / pH 2 - 3 View Scheme
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 18 h / 90 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 4 h / 20 °C 3: sodium hydroxide; water / 3 h / 50 °C View Scheme

: 147403-65-4
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / dimethylformamide / 0.5 h / 0 °C 2: xylene / 2 h / Heating 3: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 - 25 °C 2.1: sodium hydroxide; water / 0.5 h / 50 - 55 °C 2.2: 0.5 h / 20 - 25 °C / pH 2 - 3 View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane; tetrahydrofuran / 2 h / 20 °C / Cooling with water-ice 2.1: xylene / 1.5 h / Reflux 3.1: sodium hydroxide; water / 1.5 h / 70 °C 3.2: pH 3 View Scheme

: C34H40N4O6

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: xylene / 2 h / Heating 2: 94 percent / 0.4 N aq. NaOH / 1.5 h / 70 °C View Scheme
Multi-step reaction with 2 steps 1.1: xylene / 2 h / Reflux 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme
Multi-step reaction with 2 steps 1: xylene / 2 h / Reflux 2: sodium hydroxide; water / methanol / 24 h / 20 °C View Scheme

: 541-41-3
chloroformic acid ethyl ester

: 147403-65-4
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Stage #1: chloroformic acid ethyl ester; methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate With pyridine In N,N-dimethyl-formamide for 6h; Inert atmosphere; Cooling with ice-cold bath; Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 20℃; for 5h; Stage #3: With hydrogenchloride In water; dimethyl sulfoxide

: 1403477-45-1
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium methylate In tetrahydrofuran at 20℃; for 4h;	71.2 %Chromat.
Multi-step reaction with 2 steps 1.1: sodium methylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C 2.1: sodium hydroxide; water / 1.5 h / 70 °C 2.2: pH 3 View Scheme
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 4 h / 20 °C 2.1: pyridine / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Cooling with ice-cold bath 2.2: 5 h / 20 °C View Scheme

: 1403477-45-1
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

A: 147403-03-0
azilsartan

B: 147403-52-9
methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate

Conditions

Conditions	Yield
With sodium methylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h;	A 11.3 %Chromat. B 72.7 %Chromat.
With sodium methylate In dimethyl sulfoxide at 20℃; for 4h;	A 77.9 %Chromat. B 17.1 %Chromat.

: 1403477-45-1
methyl 2-ethoxy-1-((2'-(N'-(methoxycarbonyloxy)carbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

A: 147403-65-4
methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

B: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 20℃; for 4h; Product distribution / selectivity;	A 7.9 %Chromat. B 74.8 %Chromat.

: 1403474-75-8
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium ethanolate In tetrahydrofuran at 20℃; for 4h;	66 %Chromat.
With potassium tert-butylate In tetrahydrofuran at 20℃; for 4h; Product distribution / selectivity;	93 %Chromat.
Multi-step reaction with 2 steps 1: dibutylamine / 2 h / 110 - 115 °C 2: sodium hydroxide; water / 1.5 h / 70 - 75 °C View Scheme
Multi-step reaction with 2 steps 1: isopropyl alcohol / 80 °C 2: pyrographite; sodium hydroxide / water / 2 h / 55 °C View Scheme

: 1403474-75-8
ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate

A: 1403474-70-3
ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid

B: 147403-03-0
azilsartan

Conditions

Conditions	Yield
With sodium ethanolate In dimethyl sulfoxide at 20℃; for 4h; Product distribution / selectivity;	A 39.3 %Chromat. B 55.3 %Chromat.

: 139481-41-7
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride / dimethyl sulfoxide; water / 15 h / 90 °C 2: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 3: sodium hydroxide; water / 3 h / 50 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine; hydroxylamine hydrochloride / dimethyl sulfoxide / 12 h / 75 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 2 h / 20 °C 3: sodium hydroxide / 75 °C View Scheme
Multi-step reaction with 4 steps 1: triethylamine; hydroxylamine / ethanol; water / 7 h 2: triethylamine / dichloromethane / 2 h / 20 °C 3: ethanol / 15 h / Reflux 4: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme

: 1397836-41-7
ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

: 147403-03-0
azilsartan

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethyl sulfoxide; methanol / 2 h / 20 - 25 °C 2: sodium hydroxide; water / 3 h / 50 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: ethanol / 15 h / Reflux 3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 20 °C 2: ethanol / 15 h / Reflux 3: sodium hydroxide / ethanol / 1.6 h / 73 - 75 °C View Scheme

: 147403-03-0
azilsartan

: 1-[[2'-(carbamimidoyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid

Conditions

Conditions	Yield
With palladium on activated charcoal; ammonium formate; acetic acid In ethanol at 80℃; for 5h; Inert atmosphere;	96%

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

: 147403-03-0
azilsartan

: 863031-21-4
Azilsartan medoxomil

Conditions

Conditions	Yield
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 10℃; for 3h; Stage #2: In N,N-dimethyl acetamide pH=5; Stage #3: In water; acetone at 35℃; for 2h;	95%
Stage #1: 4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one; azilsartan With dmap; p-toluoylsulfonylchloride; potassium carbonate In ISOPROPYLAMIDE at -15 - 25℃; Stage #2: With hydrogenchloride In ISOPROPYLAMIDE; water for 0.5h; pH=4 - 5;	81%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl acetamide at 8 - 10℃; for 3h;	80.1%

: 135733-30-1
3-(hydroxymethyl)-4-phenylfuroxan

: 147403-03-0
azilsartan

: 3-(4-phenyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Conditions

Conditions	Yield
With dmap; triethylamine; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 5h; Reagent/catalyst; Solvent; Temperature;	94%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 10℃; for 3h;

: 127-19-5
N,N-dimethyl acetamide

: 91526-18-0
4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

: 147403-03-0
azilsartan

: 1417575-99-5
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester of 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid dimethylacetamide

Conditions

Conditions	Yield
With dmap; potassium carbonate; p-toluenesulfonyl chloride at 30℃; for 3h; Cooling;	86.4%

...Expand

: 80841-78-7
4-chloromethyl-5-methyl-1,3-dioxol-2-one

: 147403-03-0
azilsartan

: C35H28N4O11

Conditions

Conditions	Yield
With sodium carbonate; sodium iodide In N,N-dimethyl acetamide at 35℃; for 3h; Reagent/catalyst; Solvent;	85.9%

: 80715-22-6
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

: 147403-03-0
azilsartan

: C35H28N4O11

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 6h;	83%

: 80841-79-8
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide

: 147403-03-0
azilsartan

: C35H28N4O11

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran at 70 - 80℃; for 6h; Reagent/catalyst; Solvent;	78.4%

: 147403-03-0
azilsartan

: 2-oxo-3-((2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1’-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water at 20℃; for 3h; pH=2;	60%
With hydrogen bromide In ethanol at 78 - 85℃; for 1h;

: 109-99-9
tetrahydrofuran

: 693-98-1
2-methylimidazole

: 147403-03-0
azilsartan

: C25H20N4O5*C4H6N2*C4H8O

Conditions

Conditions	Yield
In water at 20℃; for 2h;	45%

...Expand

: 147403-03-0
azilsartan

: 183537-57-7
2-oxo-4-hydroxymethyl-3-methyl-1,2,5-oxadiazol

: 4-(3-methyl-1,2,5-oxadiazole-2-oxide-3-)methyl-2-ethoxy-1-{[2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazole-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Conditions

Conditions	Yield
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h;	44.4%
With dmap; potassium carbonate; p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 20℃; for 3h;	44.4%

: 693-98-1
2-methylimidazole

: 67-64-1
acetone

: 147403-03-0
azilsartan

: C25H20N4O5*C4H6N2*C3H6O

Conditions

Conditions	Yield
In water at 20℃; for 2h;	44%

...Expand

Azilsartan Specification

The IUPAC name of Azilsartan is 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid. With the CAS registry number 147403-03-0, it is also named as 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid. The product's classification code is treatment of hypertension. Moreover, its molecular formula is C₂₅H₂₀N₄O₅and its molecular weight is 456.45.

The other characteristics of Azilsartan can be summarized as: (1)XLogP3-AA: 4.4; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 7; (4)Rotatable Bond Count: 7; (5)Tautomer Count: 3; (6)Exact Mass: 456.14337; (7)MonoIsotopic Mass: 456.14337; (8)Topological Polar Surface Area: 115; (9)Heavy Atom Count: 34; (10)Complexity: 783; (11)Density: 1.42 cm³.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)O
(2)InChI: InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
(3)InChIKey: KGSXMPPBFPAXLY-UHFFFAOYSA-N

Product Name

Azilsartan

Synthetic route

Azilsartan Specification

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