The binding of trivalent metal ions to immobilized ligands is analyzed to determine the principal type of interaction, the extent of ion exchange, and changes due to through-bond communication. FTIR spectroscopy is found to be a readily accessible means of determining through-bond communication ...

In this study we investigate the Nd(NO3)3 extraction from neutral aqueous solutions with a binary extractant based on 2-ethylhexylphosphonic acid 2-ethylhexyl mono ester (HA) and tri-n-octylamine (NR3) in toluene. It is established that the NR3HA extracts Nd(NO3)3 in agreement with the laws of b...

The saponification process of di(2-ethylhexyl)phosphoric acid extractant (D2EHPA) was investigated by the isothermal titration calorimetry (ITC), attenuated total reflection infrared (ATR-IR), and small-angle X-ray scattering (SAXS) spectroscopies. The effects of the temperature, types of saponi...

Racemic 3-(4-indolyloxy)-1,2-propanediol 2 has been effectively resolved into (S)- and (R)-enantiomers by a preferential crystallization procedure. Non-racemic (S)-2 was converted into (S)-4-(2,3-epoxypropoxy)-1H-indole (S)-4 via a Mitsunobu reaction and then into (S)-pindolol (S)-1. The crystal...

In the present study, cyclosophoraoses (CyS) (β-1,2 linked cyclic glucans, with glucopyranose units ranging from 17 to 23) isolated from Rhizobium leguminosarum biovar viciae VF-39 were modified with carboxymethyl (CM) groups, and the pH-sensitive complexation of CM CyS with pindolol was invest...

The effects of the 5-HT1A receptor blocker pindolol and the 5-HT releasing and uptake blocking agent d-fenfluramine, both used as indirect serotonin agonists, on flumazenil-induced acute anxiety reactions were studied in panic disorder patients to test the hypothesis that serotonin (5-HT) inhibi...

A straightforward chemoenzymatic synthesis of (S)-Pindolol has been developed. The key step involved the enzymatic kinetic resolution of rac-2-acetoxy-1-(1H-indol-4-yloxy)-3-chloropropane with lipase from Pseudomonas fluorescens via hydrolytic process to obtain enantiomerically enriched halohydr...

Publisher SummaryThis chapter reviews the chemistry of pyrido[2,1-c]-1,4-oxazines; pyrido[2,1-c]-l,4-thiazines; pyrido[1,2-a]-pyrazines; and their benzologues. The physicochemical and spectroscopic properties, reactions, syntheses, and utilization of the ring systems are discussed in the chapter...

The effect of salt formulation on the electrostatic property of active pharmaceutical ingredients was investigated. The electrostatic property of weak acids (carboxylic acids and amide-enole type acid) and their sodium salts was evaluated by a suction-type Faraday cage meter. Free carboxylic aci...

Hygroscopicity of atmospheric aerosols is closely related to their composition, but the detailed mechanism is still poorly understood. In this study, molecular dynamics studies on water adsorption around the pure acetic acid aerosol (a binary system) and around the acetic acid-sodium halide aero...

The role of excitotoxicity on the neuropathology of glutaric acidemia type I (GA I) is still under debate. Therefore, in the present work, we evaluated glutamate uptake by brain slices and glutamate binding to synaptic membranes, as well as glutamine synthetase activity in cerebral cortex and st...

Cocrystallization and salt formation were used to produce new multicomponent forms of a novel antimalarial imidazopyridazine drug lead (MMV652103) that displayed improved physicochemical properties. The drug lead had earlier shown good in vitro potency against multidrug resistant (K1) and sensit...

Glutaric acid is one of the promising C5 platform compounds in the biochemical industry. It can be produced chemically, through the ring-opening of butyrolactone followed by hydrolysis. Alternatively, glutaric acid can be produced via lysine degradation pathways by microorganisms. In microorgani...

Sodium nitrate as an important inorganic component can be chemically formed from the reactions of nitrogen oxides and nitric acid (HNO3) with sea salt in atmosphere. Organic acids contribute a significant fraction of photochemical formed secondary organics that can condense on the preexisting ni...

Amorphous and crystalline transparent zirconia coatings were deposited on soda-lime glass by the dipping or spinning technique, using a solution of zirconyl chloride octahydrate in an aquo-organic solvent. The range of coating parameters and the corresponding properties of the coatings (thicknes...

This manuscript described a dynamic simulation of uranyl nitrate crystallization in a linear crystallizer. Furthermore, a mathematical model of the crystallizer supply system was developed with a related control algorithm; the model contained two piston feeders. The results showed the crystalliz...

The interaction between uranyl nitrate hexahydrate (UNH) and rubidium nitrate in solid state at elevated temperatures has been studied for several compositions using simultaneous thermal analysis techniques (TG–DTA–EGA), X-ray diffraction and IR spectral measurements. The formation of rubidium...

Interaction behavior of uranyl nitrate hexahydrate (UNH) and lanthanum nitrate hexahydrate (LaNH) have been investigated on the mixtures in different molar ratios of the two precursors and monitoring the reactions at elevated temperatures with thermoanalytical and X-ray diffraction measurement t...

The molecular structure of tungsten oxytetrafluoride has been studied in the gas phase by electron diffraction. A square pyramidal model with molecular symmetryC4v, as indicated by vibrational spectroscopy, gives a good fit to the experimental data. Least squares refinement on the molecular inte...

A metal-template/metal-exchange method was used to imprint covalently attached bis(8-quinolinolato)dioxomolybdenum(VI) and dioxotungsten(VI) complexes onto large surface-area, mesoporous SBA-15 silica to obtain discrete MoO2VIT and WO2VIT catalysts bearing different metal loadings, respectively....