We herein report on the forensic analysis of plasma samples to prove human poisoning with oxydemeton-S-methyl (ODM), S-(2-(ethylsulfinyl)ethyl)-O,O-dimethyl phosphorothioate. This organophosphorus pesticide is the active ingredient of Metasystox®, that was swallowed by a 77-year-old woman to com...

The insecticide demeton S-methyl sufoxide (I) is oxidized by sugar-beet cell cultures to demeton S-methy sulfone (II). Cleavage of the thioester bond of I and II formed ethanethiols which were transformed to S-methylated compounds or S-glucosides. In addition another two metabolites were identif...

5,6-Diaryl-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazolium tetrafluoroborates (hexafluorophosphate) were unexpectedly synthesized along with expected 1,3-diaryl-2-nitrotetrahydro-1H,5H-pyrazolo[1,2-a]pyrazoles, under the action of 1-nitro-2-(3-nitrophenyl)-ethylene on 6-aryl-1,5-diazabicyclo[3.1.0]hexa...

Reaction of trifluoromethanesulfonamide (triflamide) CF3SO2NH2 with 2,3-dimethylbuta-1,3-diene (2) and 2,5-dimethylhexa-2,4-diene (3) in the oxidative system (t-BuOCl+NaI) results in the formation of 2,4-dimethyl- or 2,2,4,4-tetramethyl-3,6-bis(triflyl)diazabicyclo[3.1.0]hexane through two succe...

The thermophysical properties and taste behavior of sucrose in aqueous ionic liquids {1-octyl-3-methyl imidazolium bromide and 1-octyl-3-methyl imidazolium chloride} solutions have been studied via volumetric, compressibility and viscometric properties at T = (288.15, 298.15, 308.15 and 318.15) ...

The solubility of lamotrigine was measured in aqueous mixtures of ionic liquid, 1-octyl-3-methylimidazolium bromide [OMIm][Br] up to 0.9 mass fraction at T = (293.2–313.2) K. The λ-h and van’t Hoff models with temperature dependency and Jouyban-Acree-van’t Hoff, e-NRTL, UNIQUAC and Wilson mo...

In this study, we have investigated the lipids surrounding AqpZ, and the effects of a destabilizing mutation W14A (Schmidt and Sturgis, 2017) on lipid protein interactions. In a first approach, we used Styrene Maleic Acid copolymer to prepare AqpZ containing nanodiscs, and these were analyzed fo...

The effect of 1‑octyl‑3‑methylimidazolium salicylate, [OMIm][Sal] and 1‑octyl‑3‑methylimidazolium ibuprofenate, [OMIm][Ibu] as active pharmaceutical ingredient ionic liquids (API-ILs) on the solvation properties of l-alanine in aqueous media have been investigated by thermophysical properties de...

Development of many branches of industry has stimulated the search for new, effective surfactants with interesting properties. Potential use of alkyl glucose derivatives on a large scale, raises questions about the possible risks associated with their entry into the natural environment. To be ab...

The purpose of this study was to investigate protein expression profiles of salicylate ototoxicity using proteomic analysis, and to identify whether salicylates induce apoptosis in organotypic culture of mouse cochlear cells. The adult mice were injected intraperitoneally with 400 mg/kg of sodiu...

Aging and drug-induced side effects may contribute to the deterioration of mitochondrial bioenergetics in the brain. One hypothesis is that the combination of both deleterious stimuli accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. The hypoth...

The proton ligand stability constants of methyl salicylate, ethyl salicylate and phenyl salicylate and the stepwise stability constants of manganese(II) complexes with these have been determined potentiometrically in aqueous ethanol system 50/50 (v/v) at 25°C at different ionic strengths, viz. ...

An assessment was conducted to compare the precision and accuracy of Nessler, phenate, salicylate, and ammonia electrode procedures for total ammonia nitrogen (TAN) concentration determination in waters of aquaculture. Salicylate method was selected as a standard method for its high precision an...

Animal models of salicylate-induced tinnitus have demonstrated that salicylate modulates neuronal activity in several brain structures leading to neuronal hyperactivity in auditory and non-auditory brain areas. In addition, these animal tinnitus models indicate that tinnitus can be a perceptual ...

Publisher SummaryThis chapter describes the assay method, purification procedure, and properties of phosphorylcholine-glyceride transferase. The most convenient method for the measurement of this enzyme is to determine the amount of radioactive lecithin formed from synthetic cytidine diphosphate...

Publisher SummaryThis chapter describes the assay method, purification procedure, and properties of phosphorylcholine -cytidyl transferase. The activity of the enzyme can be studied either by measuring the amount of cytidine diphosphate choline (CDP-choline) synthesized from CTP and labeled phos...

1.1. Phosphorylcholine accumulates in the dermis and basal cells of skin in the absence of glucose.2.2. Phosphorylcholine does not accumulate in brain tissue in the absence of glucose as it does in skin.3.3. Respiration in both skin and brain is increased in the presence of 2,4-dinitrophenol in ...

Affinity capillary electrophoresis was performed to quantitate the binding of Ca2+ and phosphorylcholine to human C-reactive protein (CRP). The assay requires no modifications of any of the molecules involved, uses minuscule amounts of protein (8.5 × 10−15 mol per analysis, i.e., less than 1 pm...

The purpose of this study was to prepare a thick polymer brush layer composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) and assess its resistance to protein adsorption from the dissolved state of poly(MPC) chains in an aqueous condition. The thick poly(MPC) brush layer was prepared...

Vascular stent design continues to evolve to further improve the efficacy and minimize the risks associated with these devices. Drug-eluting coatings have been widely adopted and, more recently, biodegradable stents have been the focus of extensive evaluation. In this report, biodegradable elast...