Seven polyamine conjugates of a tri(p-carboranylmethylthio)tetrafluorophenylporphyrin were prepared in high yields by sequential substitution of the p-phenyl fluoride of tetrakis(pentafluorophenyl)porphyrin (TPPF), and investigated as boron delivery agents for boron neutron capture therapy (BNCT...

Reactions of α-mercapto-β-phenylpropionic and α-mercaptophenylacetic acid hydrazides with triethyl orthoesters were conducted under N2 in glacial acetic acid and resulted in the formation of two groups of products, derivatives of 1,3,4-thiadiazin-5(6H)-ones and 2-(1-mercaptomethyl)-1,3,4-oxad...

3-[12-(Mercaptomethyl)-1,12-dicarba-closo-dodecaboran(12)-1-yl]propionic acid (1) was prepared in six steps involving sequential dithiocarboxylation and hydroxypropylation of p-carborane as key transformations.

Recently thiolated oligonucleotides have attracted significant interest due to their ability to efficiently undergo stable bond formation with gold nanoparticles and surfaces to form DNA conjugates. In this respect we became interested in the synthesis of oligonucleotides that bear short thioalk...

By employing cis-2,6-dimethylmorpholinemethylene immonium tetrachloroaluminate (5) enamines 9 and 10, prepared from 4-tert-butylpropiophenone and propiophenone with (R)-(-)-2-(methoxymethyl)pyrrolidine (8), were converted to chiral Mannich bases 11,12 with nearly 100% ee; optical purity of these...

The glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/Siah1 signaling pathway has been recognized as a sensor of nitric oxide (NO). It is associated with a variety of injurious conditions, suggesting its therapeutic potential for spinal cord injury (SCI). Sivelestat sodium (SIV), a neutrophil ela...

BackgroundChorioamnionitis, or infiltration of the chorioamnion by neutrophils, is a risk factor associated with the development of bronchopulmonary dysplasia. Increased neutrophil elastase levels are observed in the tracheal aspirates of these patients.

BackgroundSivelestat sodium (sivelestat), a neutrophil elastase inhibitor, is used to treat acute respiratory distress syndrome (ARDS). We report two cases that developed elevated C5-acylcarnitine (C5-AC) levels following treatment with sivelestat.Case 1 was a 14-day-old female infant born at 25...

Methodological criteria and procedures of Molecular Dynamics Simulated Annealing (SA) were developed for the chain folding of the elastin tetrapeptide Boc-Gly-Leu-Gly-Gly-NMe into the conformational Global Minimum (GM), starting from the all-extended structure. The mechanism of the folding evolu...

The kinetic parameters of antagonism by the delta opioid receptor selective antagonist N-t-Boc-Tyr-Pro-Gly-Phe-Leu-Thr, obtained by using moderately selective or selective agonists, were compared in the mouse vas deferens bioassay. The apparent affinity for the preferred receptor type was 6.8 ti...

Molecular dynamics simulated annealing strategies have been developed in order to perform the conformational search for complex systems. The highly flexible tetrapeptide Boc-Gly-Leu-Gly-Gly-NMe, a sequence present many times in the protein elastin, has been studied. The control parameters (heat ...

Boc-Pro-Leu-Ψ(NH-SO2)-Gly-NH2 (3) has been synthesized as the first example of a pseudopeptide incorporating the NH-SO2 junction. The crystal structure of 3 indicates that the Ψ(NH-SO2) induces a cisoidal (gauche−) conformation which induces a backbone folding and prevents the H-bonded β-turn...

This study represents an integrated approach towards understanding the vibrational, electronic, NMR, and structural aspects, and reactivity of 1-(4-chloro-phenyl)-3-phenyl-succinimide (CPPS). A detailed interpretation of the FT-IR, UV and NMR spectra were reported. The equilibrium geometry, bond...

7-Chloro-9-phenyl-2,3-dihydroacridin-4(1H)-one (3) is synthesized from 2-amino-5-chlorobenzophenone (1) and 1,2-cyclohexanedione (2) in the presence of catalyst InCl3. FT-IR, FT-Raman and FT-NMR spectra of molecule 3 have been recorded and the structure was confirmed by single crystal X-ray diff...

A series of new N'-(2-alkylthio-4-chloro-5-methylbenzenesulfonyl)-1-(5-phenyl-1H-pyrazol-1-yl)amidine derivatives have been synthesized and evaluated in vitro by MTT assays for their antiproliferative activity against cell lines of colon cancer HCT-116, cervical cancer HeLa and breast cance...

A novel series of sulfonamide derivatives 4–21 have been synthesized starting from the strategic starting material (E)-4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide 4. Two series of hydrazone 5–9, and pyridone 10–21 derivatives bearing a sulfonamide moiety were...

The structure and the vibrational frequencies of the fundamental modes of the optimized geometry of N-(phenyl)-2,2-dichloroacetamide (NPA), N-(2-chloro phenyl)-2,2-dichloroacetamide (2CPA) and N-(4-chloro phenyl)-2,2-dichloroacetamide (4CPA) have been determined by DFT/B3LYP method. A detailed v...

This study investigated the conversion of furfural to 5-hydroxymethylfurfural (HMF) and further to levulinic acid/ester in dimethoxymethane under acidic conditions, with the particular focus on understanding the mechanism for polymer formation. The results showed that furfural could react with d...

Fluorescent brightener, industrial whitening agent, has been illegally used to whitening wheat flour. In this article, computer vision technology (E-eyes) and colorimetry were employed to investigate color difference among different concentrations of fluorescent brightener in wheat flour using D...

The mass spectra of a series of tris(N,N-dialkyldithiocarbamato)metal complexes of chromium, iron, cobalt, ruthenium, rhodium and thallium have been investigated. The fragmentation patterns of these and related compounds are discussed. The major decomposition pathways involve loss of the dithioc...