The focus of this work was to explore feasibility of using blends of cellulose esters (CA 320S, CA 3980-10 or CAB 171-15) and enteric polymers (C-A-P, Eudragit® L100 or HPMCP HP-55) for delayed and enteric coating of tablets containing either diclofenac sodium (DFS, high dose) or prednisone (PDS...

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-pyretic properties. This compound is therefore used to treat pain, inflammatory disorders, and dysmenorrhea. Due to its multimodal mechanism of action and ability to penetrate placenta, diclofenac is known to ha...

Diclofenac (DCF) is among the pharmaceutical compounds of concern based on its nocuousness in environment. In this work, a novel electrochemiluminescent (ECL) immunosensor for detecting DCF was constructed using poly(etherimide)-poly(3,4-ethylene dioxythiophene): poly(styrene sulfonate) function...

Non-steroidal anti-inflammatory drugs diclofenac and naproxen are widely used for the treatment of arthritis, ankylosing spondylitis, and acute muscle pain. However, most of them are usually not metabolized and simply pass through human body. These drugs are difficult to be decomposed by general...

Degradation reactions on diclofenac-monoglycerides (3a,b), diclofenac-(p-hydroxybenzoate)-2-monoglyceride (3c), diclofenac (1), and diclofenac lactam (4) were performed at 37°C in isotonic buffer solutions (apparent pH range 1-8) containing varying concentrations of acetonitrile (ACN). The conc...

A prodrug approach for local and sustained diclofenac action after injection into joints based on ester prodrugs having a pH-dependent solubility is presented. Inherent ester prodrug properties influencing the duration of action include their pH-dependent solubility and charge state, as well as ...

The monitoring of waste water treatment plants concerning the concentration of noxious organic molecules is a pressing issue as more and more species are not removed during the treatment process. However, especially the on-site monitoring of molecules present in low concentrations (μg/L range) ...

The nonsteroidal anti-inflammatory drugs elevate cardiovascular risk, perhaps, due to their accumulation in the heart and kidneys. We designed nanodelivery systems for cardiotoxic diclofenac to reduce its presence in these organs. Diclofenac ethyl ester (DFEE) was encapsulated in traceable micel...

Solid–liquid equilibrium (SLE) data for the organic binary mixtures of n-octadecane (1) + capric acid (2) (eutectic temperature TE = 295.15 K, eutectic composition x1E = 0.412, latent heat of melting of eutectic mixture ΔfusHE = 201 J g−1), n-octadecane (1) + lauric acid (2) (TE = 298.25 K, x1...

A series of binary mixtures of Methyl Palmitate (MP) and Lauric Acid (LA) were prepared and investigated, aiming for potential phase change material (PCM) for thermal energy storage systems. The thermal analysis of the PCM binary mixtures was investigated by means of Differential Scanning Calori...

A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desor...

This work report experimental kinetic data of ethyl esters production from auto-thermal esterification of lauric acid with ethanol and also using zinc laurates (ZnL2) as catalyst. The experiments were performed in a mechanically stirred reactor evaluating the effect of temperature (120–250 °C)...

Cytarabine (Ara-C) has become cornerstones for the treatment of hatmatological malignancies for several decades; however, it still faces serious challenges in clinical applications due to its side effects such as hand foot syndrome (HFS) and stomatitis. Therefore, considerable researchers have d...

A series of arenesulfonic acid-functionalized alkyl-bridged organosilica hollow nanospheres, Si(R)Si-ArSO3H-HNS, with different bridging alkyl groups such as ethyl, phenyl, or biphenyl in the silica/carbon framework were successfully fabricated by a P123-directed sol–gel co-condensation route a...

Mesocellular foam silica-fatty acid composites can overcome the low enthalpy and high variability associated with this class of shape-stabilized phase change materials. We report the synthesis of form stable or shape-stabilized materials using lauric acid as the melting phase through solvent-les...

Mesoporous silica (e.g. SBA-15) was evaluated in the esterification of lauric acid with butanol. ZnO/SBA-15 and MgO/SBA-15 were synthesized and characterized using N2 adsorption/desorption isotherms at 77 K, 29Si magic angle spinning solid state nuclear magnetic resonance (29Si MAS NMR), X-ray d...

The susceptibility of aphids to lauric acid, a type of middle-chain fatty acids, based pesticide formulation was investigated. The insecticidal properties of lauric acid based pesticide formulation against aphids were evaluated through the three main routes of exposure: topical application, leaf...

The recent goal of sustainability in analytical chemistry has boosted the development of eco-designed analytical tools to deliver fast and cost-effective analysis with low economic and environmental impact. Due to the recent focus in sustainability, we report the use of low-cost filter paper as ...

We report for the first time the redox properties of an anion-exchange ionomer membrane, tris(2,4,6-trimethoxyphenyl)polysulfone-methylene quaternary phosphonium chloride (TPQPCl). TPQPCl was solubilized in ethanol/water solutions and films of TPQPCl at different concentrations were drop casted ...

In this study, an electrochemical sensor toward mercury ion was developed. As the sensing material directly-thiolated graphene (G-SH) was used. After the graphene synthesis and its characterization (elemental analysis, FT-IR and Raman spectroscopy, scanning electron microscopy), the best measure...