A series of bis(phenylvinyl)anthracene-based polymers containing different lengths of polar ethylene glycol groups in the main chain (P1–3) were efficiently synthesized by Wittig polycondensation. These polymers are fully soluble in volatile solvents, which helped a lot to obtain high quality f...

The neglected disease American trypanosomiasis is one of the major health problems in Latin America. Triosephosphate isomerase from Trypanosoma cruzi (TcTIM), the etiologic agent of this disease, has been proposed as a druggable target. Some bis-benzothiazoles have been described as irreversible...

Infinite dilution thermodynamic properties of organic solutes dissolved in four bis(sulfonyl)imide ionic liquids namely 1-butyl-1-methylpyrrolidinium bis(fluorosulfonyl)imide, N-propyl-N-methylpyrrolidinium bis(fluorosulfonyl)imide, 1-ethyl-1-methylimidazolium bis(fluorosulfonyl)imide and 1-meth...

In search of better α-glucosidase inhibitors, a series of bis-indolylmethane sulfonohydrazides derivatives (1-14) were synthesized and evaluated for their α-glucosidase inhibitory potential. All derivatives exhibited outstanding α-glucosidase inhibition with IC50 values ranging between 0.10 ±...

ST 1059, the pharmacologically active metabolite of midodrine, is a potent arterial and venous vasoconstrictor on isolated dog femoral vascular strips; ST 1059 is less potent than noradrenaline or norfenefrine, but more potent than etilefrine. Midodrine itself does not elicit any constrictory ef...

Emerging pollutants, such as drugs, are considered a potential hazard to the environment, and therefore advanced oxidation processes are being considered candidate tools for their elimination. Here, different oxidation processes have been investigated for the degradation of the non-steroidal ant...

The reactions of diclofenac, meclofenamic acid and 2,6-dichlorodiphenylamine were studied by pulsed and steady-state photolysis. The primary photoprocess of diclofenac is ring closure, the quantum yield of cyclization in dichloromethane and aqueous solution is Φcyc = 0.03 and 0.2, respectively....

In the present study, the spectroscopic characterization of a novel thiazole scaffold was studied. The formation of title compound 4-(2,4-dichlorophenyl)-N-(2,6-dichlorophenyl)-1,3-thiazol-2-amine(6) was evidenced through the changes in FTIR, 1H NMR, LCMS Data. The X-ray diffraction studies reve...

ObjectiveThe current study aims to investigate the analgesic effect of combining oral diclofenac potassium and cervical lidocaine cream for alleviating pain during HSG.

Halloysite is a unique biocompatible aluminosilicate clay mineral with powder particles predominantly comprising of concentrically rolled nanotubular aggregates. Some recent studies have also contributed to its prospective case in oral drug delivery and dosage forms albeit with limited commercia...

ABSTRACTStudy ObjectiveTo compare the efficacy of oral diclofenac potassium versus hyoscine-N-butyl bromide (HBB) in reducing pain perception in patients undergoing diagnostic office hysteroscopy (OH).

In this study, we prepared a magnetic composite based on amine-functionalized chitosan (aminochitosan; AmCS) and Fe3O4 to remove diclofenac sodium (DS) from water. The fabricated [email protected]3O4 composite was characterized using Fourier-transform infrared spectroscopy, transmission electron...

The presence of pharmaceutic compounds has been widely detected in water and wastewater due to the increase in their production and consumption. Since conventional treatments are not able to totally remove these microcontaminants, more efficient technologies, such as adsorption, must be investig...

Residual diclofenac sodium (DS) in the environment is harmful to human health. A promising method for DS removal is the use of adsorbents functionalized with amino groups that can form an ionic bond with the carboxyl group of DS at a suitable pH. In this work, a novel composite adsorbent compose...

Oral Thin Film (OTF) is a newly emerging drug delivery system which has many benefits for patients. Although there has been some formulation of OTF products, these have mainly been as confectionary or dental health products. The most significant benefit of this dosage format will only be realise...

The removal of the anti-inflammatory drug diclofenac, which can be determined in concentrations up to 1 μg/mL in the aquatic environment, from water samples by the use of UV light is investigated by liquid chromatography/mass spectrometry (LC/MS). It is very important to find out whether diclof...

AimsTwo natural alkaloids, methyl (M) and isopropyl (I) N-methylanthranilates, with recently demonstrated significant pharmacological activities, were assayed for their possible overall effect on intact gastric mucosa and their protective properties towards the onset of gastric lesions induced b...

We recently reported that exposure to cyclosporine (CSA) plus diclofenac causes hypertension and impairs left ventricular (LV) and cardiac autonomic functions in female rats. Here, we tested the hypothesis that these effects could be mitigated by facilitated heme oxygenase (HO) signaling. Experi...

The preparation of a new drug delivery system (DDS) based on the combination of two natural polymers chitosan (CS) and high-esterified pectin (HEP) and beidellite (Bd) was proposed. Diclofenac sodium was chosen as model drug and was loaded in the nanocomposite by means of intercalation solution ...

Diclofenac (DF) was first synthesized in the 1960’s and is currently available as ophthalmic, oral, parenteral, rectal and skin preparations. This review focuses on the administration of DF to the skin. As a member of the non-steroidal anti-inflammatory (NSAID) group of drugs the primary indica...