A series of N′-1-[2-anilino-3-pyridyl]carbonyl-1-benzenesulfonohydrazide derivatives (7a–i) was synthesized and five of them were selected by the National Cancer Institute (NCI) and evaluated for their in vitro anticancer activity. Three of the investigated compounds 7d, 7f and 7g exhibited si...

A series of N-(2-anilino-pyridyl) linked 2-amino benzothiazoles (4a–n) and [1,2,4]triazolo [1,5-b]benzothiadiazine conjugates (5a–j) have been designed, synthesized and evaluated for their antiproliferative activity. Some of these compounds (4h–k, 4n, and 5e) have exhibited potent cytotoxicit...

The postemergence graminicide, difenopenten-ethyl [ethyl 4-(4-(4′-trifluoromethylphenoxy)-phenoxy)-2-pentenoate], was rapidly hydrolyzed to its acid, difenopenten, in both susceptible wheat and resistant soybean followed by hydroxylation of the pentenoic acid side chain to a 3-hydroxy metabolit...

The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave 1,3-di-n-butyl- and 1,3-dibenzyl-2-(3,5-dicyano-6-ethoxy-4-phenylpyrid-2-yl)guani...

A new series of N-dichloroacetyl-bis(2-chlorophenyl)piperidin-4-ones 4-6 has been synthesized and characterized using IR, 1H, 13C, DEPT and 2D (COSY and HSQC) NMR spectral techniques. The NMR spectral data indicate that the N-acylpiperidin-4-ones 4-6 prefer to exist in an equilibrium between the...

A systematic study on the adsorption and association of 1-methylguanosine and 7-methylguanosine has been undertaken at the mercury|solution interface. The characteristic properties and adsorption parameters of the dilute and compact adsorption layers of both compounds were evaluated from the dou...

The mechanism of reduction of 7-methylguanosine (7-MeGuo) in buffered solution was studied by electrochemical methods. The polarographic reduction involves complex processes due to the presence of maxima (maximum of the first kind and maximum of catalytic reduction of protons). Consequently othe...

Summary7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive detection strategies. Here, we adapt a chemical reactivity assay to d...

We have compared the pH-independent rates of glycosidic hydrolysis in a carboxylate-bearing 7-methylguanosine derivative with those of a reference compound and with that of 7-methylguanosine itself. A syn-oriented carboxylate group affords catalysis in the hydrolysis reaction, although the insta...

Snurportin 1 is an adaptor protein that mediates the active nuclear import of uridine-rich small nuclear RNAs (U snRNA) by the importin-β receptor pathway. Its cellular activity influences the overall transport yield of small ribonucleoprotein complexes containing N2,N2,7-trimethylguanosine (TM...

A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer by solution association studies using 1H NMR titrations whereby methacrylic acid was shown to be ...

Preparative scale synthesis of 14 new N2-modified mononucleotide 5′ mRNA cap analogues was achieved. The key step involved use of an SNAr reaction with protected 2-fluoro inosine and various primary and secondary amines. The derivatives were tested in a parasitic nematode, Ascaris suum, cell-fr...

This paper reports an aptamer-based green approach for the electrochemical evaluation of tyrosinamide (Tyr-NH2). In this regard, at the first step, an aqueous synthetic strategy for preparing N-acetyl-l-cysteine (NAC)-capped Ag-In-S (AIS) quantum dots (QDs) with bright yellow/orange emission was...

Two new copper(II) complexes of formula [Cu2(2,5-dpp)(C2O4)2(H2O)4] (1) and [Cu2(2,5-dpp)(C5O5)2(H2O)4]·3H2O (2) [2,5-dpp = 2,5-bis(2-pyridyl)pyrazine, C2O42− = oxalate and C5O52− = croconate (dianion of 4,5-dihydroxycyclopent-4-ene-1,2,3-trione)] have been prepared and their structures determi...

Treatment of [Ru3(CO)12] with 2,5-di(2-pyridyl)pyrrole (HL1) and 2,5-di(2-(5-bromopyridyl)pyrrole (HL2) in refluxing toluene afforded the dinuclear Ru(I) carbonyl complexes [Ru2(CO)4(L)] (L = L1 (1), L2 (3), respectively). Alternatively, 1 along with a minor mononuclear product [Ru(CO)2(L1)2] (2...

The Michael addition of lithium or magnesium organocuprates and sodium dimethyl malonate to 2-alkylated 3,4-didehydropyroglutamates 7, prepared from the corresponding 4-substituted sulfoxides pyroglutamates or from benzophenone imine of glycine ethyl ester or nitrile, takes place in a stereosele...

3-Hydroxy-5,5-dimethyl-2-[phenyl(phenylthio)methyl]cyclohex-2-enone is synthesized via one-pot three-component reactions of aromatic aldehyde, substituted thiophenol and 5,5-dimethyl-1,3-cyclohexanedione catalyzed by p-dodecylbenzene sulfonic acid (DBSA) under ultrasound. Under ultrasound irradi...

New transient arenesulfenic acids were involved in the synthesis of enantiopure 2-arylsulfinyl-1,3-dienes, showing central or axial chirality of the substituted arene residue, apart from the chirality related to the stereogenic sulfur atom. Some of the obtained dienes, that is, (Sa,SS)- and (SaR...

The work here focusing on the synthesize of a novel (E)-N'-(thiophen-2-ylmethylene)-isonicotinohydrazide as polydentate O-N-S-tridentate Schiff base ligand derived from isonicotinohydrazide and their complexation with CuCl2 center. The structure of O-N-S-ligand was determined by XRD-crystal...

A conjugated monomer 2,4-hexadiyn-1,6-bis(p-toluene sulphonyl urethane) (HDTU) was synthesized. Thereafter, it was incorporated into polyvinyl alcohol (PVA), and coated on self-adhesive sheet, thus to prepare film dosimeters. The monomer and films were analyzed using X-ray diffraction (XRD), FTI...