The enantioselective reduction of 4-(p-toluenesulfonyl) butane-2-one and 5-(p-toluenesulfonyl) pentane-2-one with bakers' yeast gave the corresponding (S) alcohols in high optical purities and moderately good yields. The alcohol 2a was converted to (S)(+)parasorbic acid (4), while 2b was us...

This paper reports the measurements of liquid + liquid, solid + liquid and solid + liquid + liquid equilibrium data of the water + 2-propanol + 1-undecanol ternary system at temperatures from 275.15 to 288.15 K. The three isothermal phase diagrams show different regions depending on temperature....

ZusammenfassungCarbonyl-Valenzschwingungsfrequenzen und relative Ausbeuten der Synthesen von Tricarbonyl(2,3-dichlorbuta-1,3-dien)eisen und Tricarbonyl(2-chlorbuta-1,3-dien)eisen werden im Hinblick auf denkbare sterische Einflüsse der Chlor-Atome auf die Bildung des Tricarbonyl(hexachlorbuta-1,...

A complete interpretation of the vibrational spectra of chloroprene, 2,3-dichlorobuta-1,3-diene, 1,1,2,3-tetrachlorobuta-1,3-diene, 1,1,2,3,4-pentachlorobuta-1,3-diene and hexachlorobuta-1,3-diene has been carried out and a normal coordinate analysis of these molecules has been performed. The co...

Di-2-ethylhexyl phthalate (DEHP) has been widely used as a plasticizer in industry and can cause neurotoxicity; however, the underlying mechanism remains unclear. In the study, we found that DEHP significantly inhibited viability of mouse NE-4C neural stem cells and caused lactate dehydrogenase ...

[Objective]Di(2-ethylhexyl) phthalate (DEHP), a widely used plasticizer, may act as an endocrine disruptor and cause developmental toxicity. Differentiated human embryonic stem cells (hESCs) were used to investigate the underlying mechanism of the embryotoxicity induced by DEHP.[Materials and Me...

Di (2-ethylhexyl) phthalate is a high-production chemical widely used as a plasticizer for polyvinyl chloride products. Due to its ubiquitous presence in environmental compartments and the constant exposure of the general population through ingestion, inhalation, and dermal absorption, this comp...

Exposure of rodents to the Sertoli cell (SC) toxicant mono-(2-ethylhexyl) phthalate (MEHP) has been reported to trigger an infiltration of macrophages into the testis in an age- and species-dependent manner. Here we challenge the hypothesis that the peripubertal rat-specific infiltration of macr...

Mono-(2-ethylhexyl) phthalate (MEHP) is an active metabolite of di-(2-ethylhexyl) phthalate (DEHP). MEHP has toxic effects on cardiovascular system, but the possible molecular mechanisms are not completely elucidated. In our study, 3-methyladenine (3-MA), an autophagosome formation inhibitor, pr...

Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of ...

In this study, the interaction between di-(2-ethylhexyl) phthalate (DEHP) and calf thymus DNA (ctDNA) was investigated by a combination of multispectroscopic methods, chemometrics algorithm, cyclic voltammetry and molecular simulation. The concentration profiles of the components obtained from r...

Infertility caused by environmental pollution is becoming a global problem, but an effective prevention or treatment is lacking. Icariin (ICA) is a flavonoid used in traditional Chinese medicine. The present study investigated the possible roles of ICA in preventing testicular dysfunction caused...

The di(2-ethylhexyl) phthalate (DEHP) is a plasticizer incorporated to plastic matrices of widely used consumer products. However, it is gradually released from these products, resulting in a chronic exposure for humans. Although DEHP, similar to other members of the phthalates family, is genera...

Integration of chemical-genetic interaction data with biological functions provides a mechanistic understanding of how toxic compounds affect cells. Mono-(2-ethylhexyl)-phthalate (MEHP) is an active metabolite of di-(2-ethylhexyl)-phthalate (DEHP), a commonly used plasticizer. MEHP adversely aff...

The synthesis of 2H- and 3H-pyrazolo[4′,3′:3,4]pyrido[1,2-a]benzimidazole derivatives from 3-alkynyl- or 5-alkynylpyrazole-4-carbaldehydes and benzene-1,2-diamines was carried out using copper-free tandem cyclisation. When 2,3-diaminopyridine was used as the diamine component in this type of t...

RésuméA series of ω-perfluorooctyl-alkyl polyacrylate has been prepared and analyzed. The physico-chemical properties have been studied. Results from differential scanning calorimetry, X-ray diffraction and optical microscopy are discussed and show the influence of the number of methylene gro...

Polymer nanocomposite films, poly(1H,1H,2H,2H-perfluorooctyl methacrylate)@BaTiO3 ([email protected]3), with enhanced dielectric permittivity was fabricated via a two-step processes, consisting of BaTiO3 nanoparticle surface modification and surface initiated atom transfer radical grafting polym...

Mechanically polished copper substrates modified with ethanolic solutions (10−3 and 10−2 M) of n-dodecanethiol and 3-perfluorooctyl-propanethiol have been evaluated by X-ray photoelectron spectroscopy, contact angles and cyclic voltammetry measurements. In spite of the fact that ethanol is not n...

Two types of zinc substrates, mechanically polished and electrochemically reduced, modified with n-dodecanethiol and 3-perfluorooctyl-propanethiol have been evaluated by X-ray photoelectron spectroscopy. For both types of organothiols, it is found that the electrochemically reduced substrates le...

The catecholamine neurotransmitter dopamine (DA) exerts powerful modulatory control of physiology and behavior across phylogeny. Perturbations of DA signaling in humans are associated with multiple neurodegenerative and behavioral disorders, including Parkinson's disease, attention-deficit/...