In this study, we determined the effect of methoxime (MMB-4), asoxime (HI-6), obidoxime (LüH-6), trimedoxime (TMB-4), and pralidoxime (2-PAM) on redox homeostasis in vitro. Cultured human hepatoma cells (HepG2) were exposed to oximes at concentrations equivalent to their IC50 (assessed using MT...
Herein, we report the design, synthesis, and pharmacological properties of a series of substituted benzylidene acetone oxime ether derivatives from the corresponding oxime derivatives. All the newly synthesized compounds were investigated in vivo for their anti-inflammatory activities using carr...
The infrared spectrum of acetone oxime vinyl ether (AOVE) has been studied for the gaseous, liquid and solid phases as well as in an inert matrix at low temperatures. HF-SCF calculations have been carried out on AOVE and they predict the presence of one dominant rotamer with a heavy atom planar ...
The origin of two minor but enigmatic side bands in the Fourier-transform infrared spectrum (FTIR) of acetone oxime vinyl ether is resolved with density functional theory calculations. A comparison of vibrational frequencies as computed with Hartree–Fock self-consistent-field theory and density...
Isobaric vapor–liquid equilibria (VLE) were measured for the binary system acetone + acetone oxime methyl ether (AOME) at 101.3 kPa. The activity coefficients were correlated satisfactorily with NRTL and Wilson models. The thermodynamic consistency of the obtained VLE data was checked by Hering...
Defects in crystal structure of layered material can modify the surface states. Ion bombardment is a simple way to introduce defects into a crystal lattice in the surface region. Comprehensive scanning tunneling microscopy (STM), low-energy electron diffraction (LEED), and photoemission studies ...
Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities s...
Chloroprene (2-chloro-1,3-butadiene) is a high production chemical used almost exclusively in the production of polychloroprene (neoprene) elastomer. Because of its structural similarity to isoprene (2-methyl-l,3-butadiene) and to 1,3-butadiene, a potent trans-species carcinogen, inhalation stud...
The conjugated 1,4-di(n-N,N-dimethylaminophenyl)-1,3-butadienes (n=o-, m-, p-) were efficiently synthesised by homocoupling of the appropriate 2-chloro-1-(n-N,N-dimethylaminophenyl)ethene (n=o-, m-, p-) with stoichiometric amounts of zerovalent nickel complexes. The 1,3-butadienes were obtained ...
The cyclocondensation of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with 1,3-bis(silyloxy)-1,3-butadienes provides a convenient synthesis of benzo[c]chromen-6-ones.
The reaction of 2-chloro-1,3-bis(trimethylsilyloxy)-1,3-butadienes with various electrophiles allows a convenient synthesis of chlorinated molecules which are not readily available by other methods.
The cytotoxicity, genotoxicity, and mutagenicity of 1-chloro-2-hydroxy-3-butene (CHB), a known in vitro metabolite of the human carcinogen 1,3-butadiene, have not previously been investigated. Because CHB can be bioactivated by alcohol dehydrogenases to yield 1-chloro-3-buten-2-one (CBO), a bifu...
1-Chloro-3-buten-2-one (CBO) is a potential reactive metabolite of 1,3-butadiene (BD), a carcinogenic air pollutant. To develop tools that may help investigate the role of CBO in BD carcinogenicity and to develop biomarkers that can be used to assess BD exposure, the reaction of CBO with 2′-deo...
The oxidative dehydrogenation of isobutyronitrile was studied using an iron phosphate with a P/Fe atomic ratio of 1.2 as the catalyst. The main products were methacrylonitrile, acetone, and carbon oxides with a small amount of cyanic acid. The selectivities to methacrylonitrile were about 70 mol...
Methacrylonitrile/butyl acrylate (M/B) copolymers were prepared by bulk polymerization using benzoyl peroxide as an initiator. The Distortionless Enhancement by Polarization Transfer spectra were used to differentiate between the carbon resonance signals of methyl, methine, methylene and oxymeth...
The bulk copolymerization of methacrylonitrile with methyl, ethyl and butyl methacrylates, initiated by AIBN under high vacuum, was studied dilatometrically at 60°C. The composition of the reaction medium sensitively affects the overall rate of copolymerization in such a way that a decrease in ...
The thermal degradation of random copolymers of methacrylonitrile and styrene, prepared by free radical polymerisation using azoisobutyronitrile as initiator, has been studied using TG, DTA and TVA. Products obtained in the TVA experiments have been separated and characterised. These copolymers ...
Glycidylmethacrylate/methacrylonitrile (G/M) copolymers of different compositions were prepared and a copolymer composition was obtained from quantitative 13C NMR spectroscopy. Reactivity ratios for comonomers were calculated using the Kelen–Tudos (KT) and non linear error in variable (EVM) met...
The chemistry, industrial usage, general toxicity and experimental use of methacrylonitrile are briefly reviewed. Methacrylonitrile, a reactive, unsaturated and methylated aliphatic nitrile, has industrial applications in a variety of organic processes related to the polymer industry. Its genera...
Grafting of methacrylonitrile (MAN) onto dried maize starch using ceric ammonium nitrate (CAN) as an initiator has been studied gravimetrically under nitrogen atmosphere in aqueous medium. The percentage grafting is favoured by increasing monomer concentration and reaction time but is affected b...
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