By presenting benthic foraminifera isotope profiles and bulk geochemical composition of core sediments, we offer a mutiproxy reconstruction of the central Okhotsk Sea oceanography between ∼130 to and ∼115 kyr, related to the marine isotopic stage 5e (MIS 5e). Sediments from the site MR0604-PC7...

Loess and stalagmite records in China show different responses of Asian monsoon to the astronomical insolation during Marine Isotope Stage (MIS) 5c and 5e, raising the question whether the amplitudes of the whole Asian monsoon are linearly controlled by the astronomical summer insolation changes...

The X-ray crystal structures of (2E,5E)-2-(4-cyanobenzylidene)-5-(4-dimethylaminobenzylidene)cyclopentanone (I) and (2E,5E)-2-benzylidene-5-cinnamylidenecyclopentanone (II) are presented, compared to the gas phase structures calculated using density functional theory, and discussed in the contex...

Limnological reconstructions of primary productivity have demonstrated its response over Quaternary timescales to drivers such as climate change, landscape evolution and lake ontogeny. In particular, sediments from Lake Baikal, Siberia, provide a valuable uninterrupted and continuous sequence of...

Facies analysis, together with palynostratigraphic studies of the Kioroshi Formation, which lies beneath the northern Chiba area of the Kanto Plain of central Japan, reveal the sedimentary processes in the fluvial to coastal settings during marine isotope stage (MIS) 5e in this region. The depos...

We used tephra and phytolith stratigraphy to refine Pleistocene marine terrace chronology, with reference to reported eustatic sea levels associated with the dated marine terraces, and estimated uplift rates along the northern part of the northeast (NE) Japan forearc (the overriding plate in the...

A formulation development approach for ophthalmic solutions using a 23 factorial design is presented. Enalkiren (ABBOTT-64662), a renin inhibitor, has been shown to lower intraocular pressure in rabbits and monkeys. The influence of pH, presence of EDTA and the addition of PVP K90 to solutions o...

The quinolinone skeleton has been utilized to develop various mechanism-based immune modulators. However, the effects of quinolinone derivatives on the release of T cell-associated interleukin-2 (IL-2) have not been established. In this study, a series of novel quinolinone derivatives was synthe...

Condensation of 2-hydroxy-1-naphthaldehyde with (R)-(Ar)ethylamine yields the enantiopure Schiff bases, (R)-N-(Ar)ethyl-2-hydroxy-1-naphthaldimine (Ar = C6H5, 3-/4-MeOC6H4, 4-BrC6H4). These Schiff bases readily react with the dinuclear complex [Rh(η4-cod)(μ-O2CMe)]2 to afford the mononuclear c...

Mixtures of enantiomerically pure (S)-N-formyl-1-phenylethyamine and various racemic N-formyl-1-arylethylamine derivatives, when submitted to achiral medium pressure liquid chromatography, afforded elution profiles in which the enantiomers of N-formyl-1-arylethylamines standout as separate peaks...

2-(2-Benzamido)ethyl-4-phenylthiazole (1) was one of 1035 molecules (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6 μM and non-toxic to mammalian (Huh7) cells in a phenotypic high...

Passive immunization with cross-species antibodies triggers the patient's immune response, thereby preventing repeated treatment. Mannosamine–biotin adduct (MBA) has been described as a masking agent for immunogenic reduction and here, the immunogenicity and biological activity of MBA-coat...

(±)-Pseudophrynaminol inhibited carbamylcholine-elicited sodium-22 influx with an IC50 value of about 0.3 μM in both rat pheochromocytoma PC12 cells (ganglionic-type nicotinic receptor) and human medulloblastoma TE671 cells (neuromuscular-type nicotinic receptor). The inhibition in both cell l...

The first synthesis of (+) pseudophrynaminol, a unique pyrrolo [2,3b] indole recently isolated from the Australian frog Pseudophryne coriacea, is described.

SummaryNovel 1,3,4-Oxadiazoles bearing benzimidazole nucleus were designed, synthesized using 2-(2-(substituted phenoxymethyl)-1H-benzo[d]imidazol-1-yl)acetohydrazide and carbon disulfide. These newly synthesized benzimidazolyl oxadiazoles along with benzimidazolyl acetates and benzimidazolyl ac...

This work presents a combined experimental and theoretical study of two new metal-carboxylate coordination compounds. These complexes were prepared from (1-methyl-1H-benzimidazol-2-yl)methanol under mild conditions. The structures of the prepared compounds were characterized by single-crystal X-...

In this structure-activity relationship study, the influence of aryl substituents at position 5 or 6 on the pharmacological profile of the partial PPARγ agonist 4‘-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1‘-biphenyl]-2-carboxylic acid was investigated. This lead was previously identifi...

A novel Schiff base ligand, (E)-1-(((1H-benzo[d]imidazol-2-yl)methylimino)methyl)naphthalen-2-ol (HL), has been designed and synthesized in addition to its metal chelates [Co(L)2]·l2H2O, [Ni(L)Cl·(H2O)2].5H2O, [Cu(L)Cl] and [Zn(L)(CH3COO)]. The structures of the isolated compounds have been co...

Current study is based on the biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives 1–26, by treating metronidazole with different aryl and hetero-aryl carboxylic acids in the presence of 1,1′-carbonyl diimidazole (CDI) as a coupling...

The compound [Hb]2[Cu(mnt)2] (1) [Hb = 1-(4-((1H-imidazol-1-yl)methyl)benzyl)-1H-imidazol-3-ium] has been synthesized, starting from 1,4-bis((1H-imidazol-1-yl)methyl)benzene, cupric chloride, and Na2mnt in methanol. Compound 1 crystallizes in monoclinic system with C2/c space group. In the cryst...