A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives (1 −2 3) were synthesized and characterized by EI-MS and 1H NMR, and screened for their α-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC50 = 0.38 ± 0.82 µM) and 23 (IC50 = 1....

Two new benzimidazole salts, namely, [H2IBI]2+ 2X (X = NO3− (1), ClO4− (2) [IBI = 2-((1H-imidazol-1-yl)methyl)-1H-benzimidazole], were grown through reacting IBI and two different inorganic acids by slow evaporation method, respectively. Compounds 1 and 2 have been characterized by single–cryst...

It is shown that cycloadditions of 1,3-bis (dimethylamino) pentalenes and their 2-aza-analogues with activated alkines are frontier orbital controlled whereas protonation is charge controlled.

ESR spectra have been obtained after addition of either a cupric phenylhydantoin or a cupric diisopropylsalicylate complex to Ehrlich ascites tumor cells. It is shown that some of the complex remains in the cupric state. Because the ESR parameters of these complexes in the presence of cells diff...

A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-(thiophen-2-yl)dihydroquinolines 7a–p was designed and synthesized from 2-acetyl thiophene in six step reaction sequence involving modified Bohlmann-Rahtz and Vilsmeier-Haack-Arnold reactions as key transformati...

Utilizing molecular hybridization approach, a progression of novel pyrazolylpyrimidine based N-thioamide derivatives of piperazine were identified in an effort to develop newer antibacterial and antitubercular agents against the cumulative bacterial resistance. Spectral analysis using Mass, 1H N...

The stereoselective preparation of the β-d-GlcNAc-(1 → 4)-d-Glc disaccharide starting from known 4-O-[6-O-(1-methoxy-1-methylethyl)-3,4-O-isopropylidene-β-d-talopyranosyl]-2,3:5,6-di-O-isopropylidene-aldehydo-d-glucose dimethyl acetal (2), in turn easily obtained from lactose, is reported. Ke...

Many of estradiol's behavioral effects are mediated, at least partially, via extra-nuclear estradiol signaling. Here, we investigated whether two estrogen receptor (ER) agonists, targeting ERα and G protein-coupled ER-1 (GPER-1), can promote rapid anorexigenic effects. Food intake was meas...

Coupling of chiral 1-O-benzylglycerol-2,3-bistriflate with trilithiated chiral 2-N-Boc-3-phenylsulfonylpropan-1-ol derivative constitutes an efficient route to chiral C-5 substituted prolines which can potentially induce cis Xaa-Pro peptide bond conformation. A straightforward seven-step synthes...

Series of compounds consisting of carbazole arms and 1,3,5-triazine core linked by amino group were synthesized and characterized. The clear relationship between electrochemical properties, quantum efficiency, charge transport properties and structure were estimated. The exciplex-forming propert...

Rational approach to drug design is the process to find new potent molecules on the basis of a known target and available ligands for the target. Compared to the traditional system of drug design and discovery, that involves blind testing of different chemicals in vitro and in vivo in cultured c...

The optical and electron properties of three different s-triazine derivatives are investigated to ascertain the role of the donor acceptor character in amine-triazine systems depending on the bridging radical of the ammine group. The three derivatives were obtained starting from three different ...

Three novel series of s-triazine derivatives, including thirty-five new compounds 2a-d, 3a-3p, 4b-d, 5b-d, 6d-6d, and 7a-7f were synthesized comprising a diversity of substituents based on the structure of Astrazeneca arylaminotriazine DNA gyrase B inhibitor. The antimicrobial activity was deter...

The bisadduct of Cu(II) chloride with the potential nonadentate ligand N2,N2,N4,N4,N6,N6-hexakis((pyridin-2-yl)methyl)-1,3,5-triazine-2,4,6-triamine, [Cu2Cl4(L)]·2CH3CN, is described. Each of the 2 Cu(II) ions is in a 5-coordinate geometry, intermediate between square pyramidal and tetragonal p...

Zirconium- and hafnium-based metal–organic frameworks which constructed by 12-coordinated clusters and 6-coodinated clusters were shown to be highly effective heterogeneous catalysts for the ring opening acylation of benzoxazole to 2-arylbenzoxazole under solvent free conditions. Owning the wid...

Formation of binary complexes of Al(III), Cr(III), Fe(III), Th(IV), UO2(II), Ce(III), La(III), and Gd(III) with 3-(2-ethylamino)-1-hydroxyethyl] phenol (Effortil) were studied potentiometrically at 37.0 °C and I = 0.16 mol dm−3 NaNO3 in aqueous solution. The acid–base properties of Effortil we...

The kinetics of the hydrolysis and self-condensation reactions of 3-(2-amino-ethylamino)propyl-trimethoxysilane (DAMS) were investigated by in situ 29Si NMR spectroscopy using pure water and an alcoholic (80:20 w/w ethanol/water) solvent mixture as reaction media. In both media, the reactivity o...

Effective photosensitizers are particularly important factor in clinical photodynamic therapy (PDT). However, there is a scarcity of photosensitizers for simultaneous cancer photo-diagnosis and targeted PDT. Herein, two novel dimethyl 2-(guanidinyl)ethylamino chlorin e6 photosensitizers were syn...

Physical N2O solubility in pure 2-(ethylamino)ethanol (EAE) solvent was measured over the temperature range 289.6– 349.7 K. The physical solubility of CO2 in EAE was then derived via the “N2O analogy” method. The effect of structural characteristics such as carbon chain length, hydroxyl group...

The absorption amount (m) and loading (α) of CO2 in 2-(ethylamino)ethanol (EAE) activated 3-(dimethylamino)propan-1-ol (3DMA1P) aqueous solution were measured. The temperatures ranged from 303.2 K to 323.2 K. The mass fractions of 3DMA1P and EAE respectively ranged from 0.3 to 0.5 and 0.01 to 0...