Emission and excitation spectra of 2,6-dimethyl-4H-pyran-4-thione (DPT) vapor have been measured at different buffer gas pressures from 0 to 300 Torr and at different temperatures. Emission property of DPT vapor is found to vary significantly depending on pressure, excitation energy and temperat...
The palladium-catalyzed cross coupling of 3-iodopyridine, long chain 1,ω-dienes, and benzylic amines or tosylamides provides a novel route to key intermediates for the synthesis of the naturally occurring, biologically active pyridine alkaloids theonelladins C and D, niphatesine C and xestamine D.
We have previously demonstrated that hepatocyte proliferation induced by the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP. is independent of changes in cytokines, immediate early genes, and transcription factors that are considered to be necessary for regeneration of the liver af...
The method of exhaustive methylation has been applied for investigating tautomeric stability and its temperature variation of 6-hydroxy-5-methyl-3-pyridazinone (1) and its N-phenyl derivative (2)—two model compounds chosen for studying tautomeric transformations of pyridazine medicinal drugs, e...
This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[2, 2, 2]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a ...
The crystal structure of Cu(4-Brpy)2(NCS)2 exhibits two symmetrically independent pseudo-octahedral coordination polyhedra of Cu(II). The unit cell parameters are: a = 8.568(3), b = 9.200(3), c = 10.809(5) Å, α = 72.64(3), β = 86.15(3), γ = 80.14(3)°, triclinic symmetry, space group P1, Z = ...
Surface enhanced Raman scattering (SERS) studies of 4-bromopyridine (4BP) adsorbed on colloidal AuPt alloy particles with 0, 1, 5, and 25 g% Pt show the same spectral features as that of 4BP adsorbed on pure Au particles. The excitation profile of major Raman bands of 4BP on alloy particles pe...
The mechanistic study of the palladium-catalyzed Suzuki–Miyaura cross-coupling between bromophenylpyridine compounds and phenylboronic acid led to the NMR identification of a transient intermediate in the transmetalation step. This species was identified by DFT calculations as a [Pd{Ph-B(OH)3−}...
Phosphorous pentaoxide (P2O5) effectively catalyzed homogeneous liquid-phase Beckmann rearrangement of cyclohexanone oxime to ε-caprolactam in N,N-dimethylformamide (DMF). The turn-over number (TON) of P2O5 was 20. The catalytic activity was greatly increased by addition of a co-catalyst, trifl...
Pd nanoparticle-poly(N-vinyl-2-pyrrolidone)/CMK-3 (Pd-PVP/CMK-3) composite was prepared by in situ polymerization method which was effectively employed as a novel heterogeneous catalyst for the Suzuki–Miyaura cross-coupling reaction. The physical and chemical properties of Pd nanoparticle-PVP/C...
Composite poly(N-vinyl-2-pyrrolidone)/KIT-5 (PVP/KIT-5) was prepared by in situ polymerization method and used as a support for palladium nanoparticles obtained through the reduction of Pd(OAc)2 by hydrazine hydrate. The physical and chemical properties of the catalyst were investigated by XRD, ...
We have designed and synthesized certain novel oxime- and amide-bearing coumarin derivatives as nuclear factor erythroid 2 p45-related factor 2 (Nrf2) activators. The potency of these compounds was measured by antioxidant responsive element (ARE)-driven luciferase activity, level of Nrf2-related...
The usual cause of premature death in patients with homocystinuria due to cystathionine β-synthase deficiency (EC 4.2.1.22) is vascular disease which occurs with high plasma-homocysteine concentrations. In animal models, experimental homocysteinemia produced by chronic homocysteine thiolactone ...
One-pot multi-step reactions based on thiolactone chemistry emerged as a powerful tool to prepare tailor-made, multi-functionalized polymer architectures in a one-pot and elegant manner. This feature article highlights the most important features of this approach, demonstrated in various reactiv...
Homocysteine thiolactone (Hcy-thiolactone), an intramolecular thioester, easily acylates free-amino groups in proteins, which impairs or alters the protein's biological function. Here, we describe new capillary electrophoresis assay for the determination of Hcy-thiolactone in human urine ba...
Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical translation of nanomedicine owing to their self-assembly into well-defined core-shell nanoparticles for improved pharmacokinetics, stability in blood circulation without drug leakage, and optimized biodistribution...
A library of multifunctional monomers from homocysteine thiolactone and thioparaconic acid were synthesized using straightforward chemistry routes. A generic protocol was developed, leading to multi-gram amounts of the targeted compounds and enabling up-scaling experiments for promising compound...
A novel, straightforward chemical platform to prepare polymers with covalently bound amine functional groups has been developed for applications as coatings that scavenge formaldehyde emissions. For the polymer preparation, an amine-thiol-ene conjugation process was used to combine N-(allyloxy)c...
A set of multifunctional UV-cured thiol-ene polymer resins were systematically prepared from thiolactone containing monomers and different amine compounds. Aminolysis of the thiolactone moiety enabled the introduction of different side chains and cross-linkers into the polymers. The glass transi...
A wide set of norbornene-derived polymers with a diversity in backbone and side chain structures has been prepared based on norbornene building blocks that also include a thiolactone group. For this purpose, two thiolactone monomers with differently substituted norbornene moieties were synthesiz...
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