In the present investigation, a series of novel {5-chloro-2-[(3-(substitutedphenyl)-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones (3a–i) have been synthesized from 5-(chloromethyl)-3-substitutedphenyl-1,2,4-oxadiazole (2a–i). The newly synthesized compounds were characterized by I...
A novel Pt(II) complex of [PtII(MPP)(OPD)]Cl⋅H2O (MPP-Pt) (OPD = o-phenylenediamine) with 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin (H-MPP) was synthesized and fully characterized. In MPP-Pt complex, the Pt(II) ion adopts a four-coordinated square planar geometry. MPP-Pt exhib...
B3LYP/6-311+G** level of theory is used to investigate the C–H⋯O hydrogen bond formed by chloroform and two conformers of triformylmethane (TFM), i.e. cis-TFM (concerned with C1 configuration) and trans-TFM (concerned with C2 and C3 configurations). Polarized continuum model (PCM) is used to st...
Molecular structure and vibrational frequencies of triformylmethane have been investigated by means of density functional theory (DFT) calculations. The geometrical parameters and vibrational frequencies obtained in the B3LYP, B3PW91, BLYP, BPW91, G96LYP and G96PW91 levels of DFT and compared wi...
The strong intramolecular hydrogen bond in triformylmethane was studied with ab-initio calculations. All possible conformations of the two tautomeric structures (keto and enol) of triformylmethane were fully optimized at HF, MP2 and B3LYP levels with 6-31G** basis set in order to determine the c...
Novel 2-iminiomethylvinamidinium trihalides were isolated as stable crystals and found to be useful triformylmethane synthons with non-deliquescent nature in air. They were easier to manufacture, handle, and store than the known 2-iminiomethylvinamidinium dichloride. By virtue of in situ aminal ...
Self-methathesis of vegetable oil based unsaturated fatty acids provide a renewable and convenient route for the preparation of a number of platform chemicals useful for the production of polymers, biolubricants and other industrial products. The present study is focused on the use of the unsatu...
The first total synthesis for the (Z)-17-methyl-13-octadecenoic acid was accomplished in seven steps and in a 45% overall yield. The use of (trimethylsilyl)acetylene was key in the synthesis. Based on a previous developed strategy in our laboratory the best synthetic route towards the title comp...
An H1004A-C1006S variant of Aspergillus nidulans diol synthase was identified as an 8-dioxygenase. Whole recombinant Escherichia coli cells expressing the double-site variant showed the highest activity for converting linoleic acid to 8-hydroperoxy-9,12(Z,Z)-octadecadienoic acid (8-HPODE), which...
Production of (Z)-11-(heptanoyloxy)undec-9-enoic acid from recinoleic acid was achieved by whole-cell biotransformation by Escherichia coli, utilizing crude glycerol as the sole carbon source. Whole-cell biotransformation resulted in ∼93% conversion of the substrate ricinoleic acid to (Z)-11-(h...
We have performed a study of structural, thermochemical and thermophysical properties of the (Z)-cinnamic acid neutral molecule and its corresponding oxyanion (formed by deprotonation of the carboxylic group). The thermophysical study (heat capacities, temperature and enthalpy of fusion) was mad...
A photocatalyst of Ag2S/AgI-Bi2S3/BiOI was synthesized with Z-scheme heterojunctions simply by the S2−-I− anion exchange route showing broad visible light response and enhanced photogenerated carriers properties. The yielded Ag2S/AgI-Bi2S3/BiOI could feature the reactive active sites of Bi2S3/Bi...
A trichloromethyl ester devoid of suitably substituted CC bond, any leaving group or a H-atom at the β-position to the radical, which are otherwise known for ATRA/ATRC, 1,2-rearrangement/fragmentation or simple 1,2-H shift respectively, in a reaction of trichloro-acetic acid phenyl ester with 2...
Milk and dairy products are major sources of fat in the human diet, but there are few detailed reports on the fatty acid composition of retail milk, trans fatty acids in particular, and how these change throughout the year. Semi-skimmed milk was collected monthly for one year from five supermark...
Anacardic acids, 6-pentadec(en)ylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae) nut and apple, were found to possess preventive antioxidant activity while salicylic acid did not show this activity. These anacardic acids prevent generation of superoxide radical...
Anacardic acid derivatives exhibit a broad range of biological activities. In this report, an efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicylic acid variants synthesised retaining a constant hydrophobic element (a naphthyl tail). The naph...
Lipoxygenases catalyze the oxidation of unsaturated fatty acids, such as linoleic acid, which play a crucial role in inflammatory responses. Selective inhibitors may provide a new therapeutic approach for inflammatory diseases. In this study, we describe the identification of a novel soybean lip...
Earlier studies from our laboratory have identified Anacardic acid (AA) as a potent inhibitor of gelatinases (MMP-2 and 9), which are over-expressed in a wide variety of cancers (Omanakuttan et al., 2012). Disruption of the finely tuned matrix metalloproteinase (MMP) activator/inhibitor balance ...
Potential toxicity due to nonspecific distribution is one of the major challenges with currently available chemotherapeutics. In the present report we have developed Docetaxel (DTX) loaded Anacardic acid (AA) functionalized liposomes (DTX-AA-PEG-Liposomes) to have the advantage of selective dist...
In an attempt to explore the biosynthetic potential of endosymbiotic fungi, the secondary metabolite profiles of the endophytic fungus, Anteaglonium sp. FL0768, cultured under a variety of conditions were investigated. In potato dextrose broth (PDB) medium, Anteaglonium sp. FL0768 produced the h...
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