The solubility and dissolution thermodynamics of (2Z)-N-cyclohexyl-2-(3-hydroxybenzylidine) hydrazine carbothioamide (CHBH) in various 2-(2-ethoxyethoxy)ethanol + water mixtures from (298.15 to 338.15) K were studied in the present investigation. The solubilities of CHBH were measured using an i...
7α-Alkylation and 7,7-bis-alkylation of 20-hydroxyecdysone with propargyl bromide in a lithium–ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ8(14)-20-hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% ...
This chapter describes the pyrolysis of various types of hydrocarbons. The first section presents pyrolysis for acyclic-saturated hydrocarbons such as methane, ethane, propane, butane, and isobutene; other low molecular weight saturated hydrocarbons; n-dodecane; and higher molecular weight alkan...
(Phosphonomethyl)phenylalanine (Pmp) and (phosphonodifluoromethyl)phenylalanine (F2Pmp) as well as their β-amino acid congeners were prepared as a protecting variant amenable to the peptide synthesis from readily available 2-benzyl-1,3-propandiols possessing either a diethylphosphonomethyl- or ...
A series of novel fluorinated Asiatic Acid (AA) derivatives were successfully synthesized, tested for their antiproliferative activity against HeLa and HT-29 cell lines, and their structure activity relationships were evaluated. The great majority of fluorinated derivatives showed stronger antip...
We report a synthesis of a single enantiomer of a mycolic acid from Mycobacterium tuberculosis containing a di-cis-cyclopropane. The method can be simply varied to modify the chain lengths or the absolute stereochemistry of either cyclopropane.
The synthesis of three stereoisomers of a major homologue of the methoxymycolic acids present in Mycobacterium tuberculosis is described.
We report the syntheses of a single enantiomer of an unprotected ketomycolic acids containing a cis-cyclopropane and of related hydroxy-mycolic acids.
A series of novel fusidic acid (FA) derivatives were synthesized and screened for their in vitro cytotoxicity against the Hela, U87, KBV and MKN45 cancer cell lines. Selected FA derivatives with anti-tumor activity were firstly identified including compound 4, which exhibited good anti-prolifera...
The reaction of bis[(5a,6,6a,10a,10b-η)-5-phenyl-5,6-dihydroindeno[2,1-b]indol-6-yl]dimethylsilane dilithium salt with ZrCl4 results in the formation of zirconium ansa-complex with >95% rac-selectivity, presumably due to specific crystal structure of the dilithium salt, which was established by...
The combined computational and experimental studies arrived at a conclusion that these two compounds can influence the morphology of salt crystals, which is contrary to the previous report. The periodic surface three dimensional (3D)-slab model computed results predict that 2-amino-pentanoic aci...
This study presents a method to calculate the surface tension of a wide variety of organic carboxylic-based acids molecules starting from the experimental data of the liquid viscosity. The first step of this research was a data collection and then an accurate selection of experimental sources fo...
The origin of fatty acids on the prebiotic Earth is important as they likely formed the encapsulating membranes of the first protocells. Carbon-rich meteorites (i.e., carbonaceous chondrites) such as Murchison and Tagish Lake are well known to contain these molecules, and their delivery to the e...
A novel type III fungal CAR was identified from the organism Thermothelomyces thermophila. High expression levels were observed in E. coli using the pETDuet-1 plasmid system in combination with an autoinduction protocol. A broad substrate scope ranging from aromatic to aliphatic carboxylic acids...
Lactobacillus sakei belongs to the main flora of raw fermented sausages and is used as starter culture. Bacterial starter cultures can convert amino acids to α-keto acids by aminotransferases. These α-keto acids are the precursors of aroma active aldehydes, alcohols and carboxylic acids. In th...
(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid, a novel amino acid constituent of bleomycin, has been synthesized stereoselectively through aldol condensation of (R)-2-aminopropionaldehyde derivatives and E-vinyloxyboranes.
Dilution enthalpies of aqueous solutions of 3-amino propanoic acid, 4-amino butanoic acid, 5-amino pentanoic acid, and 6-amino hexanoic acid were determined at T = (293.15, 298.15, 303.15, and 308.15) K using an LKB flow microcalorimeter. The homotactic interaction coefficients were obtained acc...
The responses of Charles River and Fischer-344 rats to dietary 1·5% nitrilotriacetic acid and 2% trisodium nitrilotriacetate, monohydrate were compared in a 4-wk feeding study. The Charles River rats consumed more nitrilotriacetate (μmol/kg body weight/day) than the Fìscher-344 rats. In spite...
The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA · H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male...
The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 × 10−2 − 2 × 10−8 M) for 24 h, and cytotoxicity determi...
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