Methohexital is a rapidly-acting inducing agent for anesthesia, but currently has limited clinically usefulness except in a few particular situations. It is highly lipid soluble and its short duration of action is due to redistribution to leaner tissues and ultimately fat stores.
Pharmacologic provocative testing (PT) and intraoperative neurophysiologic monitoring (IONM) both mitigate and predict risks associated with endovascular embolization procedures. We present a series of patients undergoing endovascular intracranial embolization predominantly for AVMs both under g...
The preparation and antigenic properties of estriol 16-glucuronide-bovine serum albumin (BSA) and estradiol 17-glucuronide-BSA conjugates in which the hapten molecule is linked to the carrier protein through an (O-carboxymethyl)oxime bridge at the C-6 position on the steroid nucleus, have been d...
The preparation and antigenic properties of estriol 3-sulfate 16-glucuronide-bovine serum albumin (BSA) conjugate in which the hapten is linked to the carrier through an (O-carboxymethyl)oxime bridge at the C-6 position on the steroid nucleus, have been described. Coupling of 6-oxoestriol 3-sulf...
The reaction of the 3-benzyl ether of dimethyl marrianolate (I) with triphenylmethylsodium and then 3H2O produced I-3H in good yield. Treatment of I-3H with sodium in liquid ammonia (acyloin condensation) produced 16-ketoestradiol-15-3H. The latter was reduced by sodium amalgam to estriol-15-3H....
The di-potassium salt of estriol-3-sulfate-16-glucuronide [17β-hydroxy-3-sulfooxyestra-l,3,5(lO)-trien-16α-yl-β-=D-glucopyrano-siduronic acid di-potassium salt] (11) has been synthesized by a pathway utilizing the direct condensation of methyl (2,3,-tri-O-acetyl-α-bromo-=D-glucopyranosid)ron...
An efficient and convenient procedure for the synthesis of estriol 16- and 17-monoglucuronides from estriol is described. This is achieved by the selective protection and deprotection of the hydroxy groups in estriol, Koenigs-Knorr reactions with methyl 1-bromo-1-deoxy-2,3,4-tri-O-acetyl-α-d-gl...
Single crystal of l-serine methyl ester hydrochloride (LSMEHCl), was grown using slow evaporation solution growth technique. The grown crystal was confirmed by single crystal X-ray diffraction and the presence of functional groups were identified by FT-IR analysis. From the Optical transmission ...
Solid inorganic–organic composites were synthesized from cesium dihydrogen phosphate (CsH2PO4, CDP) and guanine (C5H5N5O, Gn) to use the solid proton conductive electrolytes. CDP and Gn were mechanochemically milled in dry nitrogen atmosphere to obtain composites with xCDP·(100 − x)Gn (x = 90–...
N-methyl-2-pyrrolidone (NMP), which undergoes extensive biotransformation, has been shown in vivo to cause developmental toxicity and, especially after oral treatment, malformations in rats and rabbits. Data are lacking as to whether the original compound or one of its main metabolites is respon...
An analytical method using a combination of solid-phase extraction (SPE) and gas chromatography with a flame thermionic detector (GC/FTD) was developed for determination of N-methyl-2-pyrrolidone (NMP), N-methylsuccinimide (MSI), and 2-hydroxy-N-methylsuccinimide (2-HMSI) in human urine. The SPE...
A method for simultaneous determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in urine is described. These compounds are metabolites of N-methyl-2-pyrrolidone, a powerful and widely used organic solvent. 5-Hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide...
A method for simultaneous determination of 5-hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) was developed. These compounds are metabolites from N-methyl-2-pyrrolidone (NMP), a powerful and widely used organic solvent. 5-HNMP and 2-HMSI were purified from plasm...
A method for determination of N-methylsuccinimide (MSI) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in human urine and of MSI in human plasma was developed. MSI and 2-HMSI are metabolites of the widely used organic solvent N-methyl-2-pyrrolidone (NMP). MSI and 2-HMSI were purified from urine and ...
The enantiomers of (anti-1,2-dimethyl-3-methylenecyclopentyl)acetaldehyde, one of which is the female sex pheromone of the pineapple mealybug (Dysmicoccus brevipes), were synthesized. Chirality was introduced by means of lipase-catalyzed asymmetric acetylation of (±)-2,3-dimethyl-2-cyclopenten-...
Sultones, the internal esters of hydroxysulfonic acids, correspond to lactones, and are generally five- or six-membered rings, with or without olefinic bonds.Sultams, the nitrogen analogs of sultones, stem from gamma, delta, and epsilon-aminosulfonic acids. No sultones or sultams of beta-hydroxy...
Treatment of [1,3,5]triazine-2,4,6-tricarboxylic acid triethyl ester (4) with arylhydrazines provided 5-amino-6-oxo-1,6-dihydro[1,2,4]triazine-3-carboxylic acid ethyl esters 5a–g in moderate to good yields. Hydrolysis under basic conditions gave the corresponding free carboxylic acids 6a–d. De...
1-Amino-2-azidobenzimidazole 7, 7-amino-8-azido- 9 and 9-amino-8-azido-theophillines 12, on heating in chlorobenzene solution, lose a molecule of nitrogen and finally give 3-amino-derivatives of benzo-1,2,4-triazine 3, 5,7-dimethylpyrimido[4,5-e]-1,2,4-triazine-6,8-dione 10 (isofervenulin) and 6...
A new series of Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared with bidentate ligand derived by condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 3-(p-bromophenyl)-1-phenyl-1H-pyrazolecarboxaldehyde. The Schiff base and its metal complexes were characterized on the...
A Sonogashira/copper(I)-catalyzed heteroannulation sequence was developed to convert 3,5-diamino-6-chloro-1,2,4-triazines to the corresponding 3-amino-5H-pyrrolo[2,3-e]-1,2,4-triazine derivatives in good yields.
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