Adverse side effects of conventional chemotherapy, acquired resistance and fatal tumor metastasis of human colorectal cancer (CRC) are propelling the exploration for novel selective anticarcinogens. Solasodine is a main active component isolated from Solanum incanum L that exhibited a potent ste...
The binary mixture of ethanolic extract of Polianthes tuberosa powder, hecogenin, tigogenin, Trachyspermum ammi seed powder and thymol with synergiats MGK-264 and piperony butoxide in a 1:5 ratio were used against the L. acuminata. It was observed that the toxic effect of these mixtures were tim...
Studies were carried out on the synergistic effects of MGK-264 used in conjunction with two synthetic pyrethroids deltamethrin and fenvalerate on the aquatic snail Lymnaea acuminata. Log-dose probit lines were prepared according to the probit analysis of Finaey1. For the computation of data, a c...
Three nonreducing disaccharides containing D-glucosyl and D-fructosyl groups, namely, “isosucrose” octaacetate (3), sucrose octaacetate (4), and “α,α-sucrose” octaacetate (5), give qualitatively identical mass spectra and are, therefore, related as diastereoisomers. Spin-coupling values in...
A sucrose octaacetate (SOA) gradient HPLC evaporative light scattering detection (ELSD) and low-wavelength UV-diode array detection (UV-DAD)-specific stability-indicating method development and validation comparison is reported. A central composite response surface design and multicriteria optim...
Genes implicated in consumption of a bitter compound, sucrose octaacetate (SOA), were investigated using a full genomic scanning strategy. For a 0.1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa l...
Taste buds were counted in two strains of mice which have been characterized in terms of their taste avoidance of the bitter-tasting substance, sucrose octaacetate (SOA). One strain (SWR/J) avoids SOA and is referred to as ‘taster’ while the other strain (C57BL/6J) does not avoid SOA at the sa...
The first examples of deacetylation of sucrose octaacetate using proteases and lipases in organic solvents are reported. The regiochemistry of the product sucrose hepta-, hexa- and pentaacetates was established by perdeuteroacetylation and 1H-NMR. Preparation of key intermediates in the commerci...
In this study, 9-hydroxy-folianin and sucrose octaacetate were isolated from the seed ethanol extract of Annona cornifolia A. St. -Hil. (Annonaceae). We found that 9-hydroxy-folianin was able to inhibit several clinical strains of the pathogenic fungus Paracoccidioides brasiliensis. The minimal ...
Highly crystallized polyaniline (PANI) nanostructures were polymerized by oxidative polymerization in the presence of sucrose octaacetate acting as an in situ seed and a soft template, and ammonium peroxydisulfate (APS) acting as an oxidizing agent. PANI nanofibers and nanorods were obtained usi...
The development of low cost, non-fluorous, CO2-philic materials such as sugar acetates have opened up new opportunities for enabling the utilization of liquid and supercritical carbon dioxide (scCO2) as a green solvent platform for industrial processes by virtue of the high solubility of these m...
Sucrose octaacetate (SOA) is a United States National Formulary (NF) monograph compendial material (U.S. Pharmacopeia, 2008), and, as shown in Fig. 1, has eight acetate groups attached to a sucrose moiety. It is a natural product that has been extracted from the seeds of Annona cornifolia (Lima ...
In vitro and in vivo studies in the rat and in man were conducted on the metabolic fate of sucrose acetate isobutyrate (SAIB). In vitro studies with rat tissues showed that SAIB was substantially hydrolysed by non-specific esterases associated with the intestinal mucosa; little hydrolysis occurr...
Sucrose acetate isobutyrate (SAIB), a mixture of esters of sucrose with a composition approximating the name sucrose diacetate hexaisobutyrate, has been used for over 30 years in many countries as a ‘weighting’ or ‘density-adjusting’ agent in non-alcoholic carbonated and non-carbonated bever...
Streptococcus equi causes equine strangles, a highly contagious disease of the upper respiratory tract. The antiphagocytic surface protein SeM is strongly immunogenic and evokes mucosal and systemic antibodies during convalescence. The present study investigated the potential of sucrose acetate ...
Sucrose acetate isobutyrate (SAIB) was tested for potential genotoxic activity in four different in vitro assay systems. Two independent trials of a Salmonella reverse mutation assay (using strains TA98, TA100, TA1535, TA1537 and TA1538) showed no increases in revertant frequencies at doses up t...
Introduction: Sucrose acetate isobutyrate (SAIB) is a water insoluble, biodegradable gel used for controlled-release oral and subcutaneous drug delivery. We investigated SAIB compatibility in the rat central nervous system (CNS) by implanting solutions of SAIB in adult and in neonatal brains. Me...
This study investigated the suitability of microsphere formulations for extended protein delivery and complete protein release. These microspheres were prepared by a multi-emulsion method and prepared using a mixture of poly(lactide-co-glycolide) (PLGA), RG 502H (lactide:glycolide = 50:50, MW 93...
Localized drug delivery strategies for cancer therapy have been introduced for decades as a means of increasing drug concentration at tumor target site and minimizing systemic toxicities. In this paper, a combination of microspheres (MSs) and sucrose acetate isobutyrate (SAIB) in situ-forming im...
ABSTRACTThe objective of this study was to develop sustained‐release sucrose acetate isobutyrate (SAIB) in situ formulations of risperidone for parenteral delivery. The formulations contained SAIB, solvent (anhydrous ethanol, ethyl lactate, or N‐methyl‐2‐pyrrolidone), and additives such as p...
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