Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis. Inhibition of ACC activity in the sebaceous glands is designed to substantially affect sebum production, becau...

BackgroundCarnitine palmitoyltransferase (CPT) II deficiency is one of the most common forms of mitochondrial fatty acid oxidation disorder (FAOD). However, newborn screening (NBS) for this potentially fatal disease has not been established partly because reliable indices are not available.

Chitosan microparticles were mixed with chitosan and carboxymethyl cellulose solution to achieve a good binding between the microparticles. Three different compositions of scaffolds were made by varying the calcium phosphate (CaP) amount: 0%, 10%, and 20%. Potassium chloride was used as salt, to...

This paper assesses the morphological, structural and bio-physicochemical stability of natural rubber (NR) Hevea brasiliensis coatings incorporated with microparticles of calcium phosphate-based (CaP) bioactive ceramics. Optical and electronic spectroscopic imaging techniques were employed to su...

To increase the water resistance of gypsum-based stuccoes (i.e., pastes and mortars), the possible conversion of gypsum into less soluble calcium phosphates (CaP), by reaction with an aqueous solution of diammonium hydrogen phosphate (DAP), was investigated. The effect of several reaction parame...

Selective flocculation of tribasic calcium phosphate (TCP), a model system for apatite, from mixtures with quartz using polyacrylic acid (PAA) was studied as a function of molecular weight of the polymer and suspension pH. A feed (1 : 1 synthetic mixture) assaying 21% P2O5 was upgraded to 32% P2...

The effect of polymer molecular weight and anionic character on selective separation of kaolinite from tribasic calcium phosphate (TCP) using hydrolyzed polyacrylamides in the presence of sodium hexametaphosphate dispersant was studied. Selectivity was observed to be strongly influenced by the m...

Calcium phosphate slurry processing is a novel chemical treatment that leads to the formation of surface layer including calcium phosphate in one-step. The processing involves burying a metallic substrate in a slurry-like agent comprised of calcium phosphate powder and distilled water followed b...

Immediate release, compositionally proportional formulations of acyclovir comprising porous tribasic calcium phosphate were developed and compared with commercial tablets. Comparison of the dissolution behavior was carried out using a compendial method, as well as with the help of a biorelevant ...

The mid and far i.r. absorption spectra of three disubstituted phenols, namely 4-nitro-3-methyl-, 2-amino-4-nitro- and 4-amino-3-methylphenol were recorded. Vibrational assignments are proposed, assuming Cs symmetry for the molecules.

Six isotypic R6ZTe2 phases have been synthesized in Ta at elevated temperatures and characterized by single crystal X-ray refinements for R=Y, Z=Rh, Pd, Ag, Y and for R=Lu, Z=Cu, Ag. All crystallize in the Sc6PdTe2-type structure, Pnma, Z=4, a∼21.5 Å, b∼4.1 Å, c∼11.4 Å. The results can be vie...

The two new quaternary cesium copper(I) rare-earth metal(III) tellurides CsCu2Sc3Te6 and CsCuY2Te4 were prepared at 900 °C by reacting the elements copper, scandium or yttrium and tellurium together with CsBr as flux and cesium source for fourteen days in evacuated torch-sealed silica ampoules....

The range of applications of epithermal neutron scattering experiments has been recently extended by the development of the Resonance Detector. In a Resonance Detector, resonant neutron absorption in an analyzer foil results in prompt emission of X- and γ-rays which are detected by a photon cou...

Three new ternary rare-earth zirconium chalcogenides, Ce2ZrSe5 (1), Pr2ZrSe5 (2) and Nd2ZrSe5 (3), have been synthesized by a facile solid-state route with boron as the reducing reagent. They crystallize in the space group Pnma of the orthorhombic system, belonging to the U3Se5 structure type. T...

Amorphous chalcogenide films play a motivating role in the development of integrated planar optical circuits and their components. The aim of the present investigation was to optimize deposition conditions for preparation of pure and Tm3+ doped sulfide films by radio-frequency magnetron sputteri...

The aim of this work is to determine the activation experimental conditions of ZnS by thulium (Tm3+) as well as in polycrystalline (cubic or hexagonal) or in monocrystalline (cubic with some stacking faults) forms. The study of numerous fluorescence spectra, mainly in the region of the blue tran...

The title compound has been prepared by high temperature techniques. A single crystal X-ray study has identified the structure type and composition of Tm15S22 with space group C2m, Z = 2, a = 38.395(4) Å, b = 3.8421(5) Å, c = 11.141(2) Å, β = 91.02(1)°; RRw = (2.56/2.95)% for 1072 independe...

The biodesulfurization of sulfide wastewater for elemental sulfur recovery by isolated Halothiobacillus neapolitanus in an internal airlift loop reactor (IALR) was investigated. The flocculant producer Pseudomonas sp. strain N1-2 was used to deposit the produced elemental sulfur during biodesulf...

Energy transfer processes in Thulium–Bismuth co-doped germanate fiber amplifier at 1800 nm region have been studied quantitatively in this work. Energy transfer models are utilized in order to investigate the effect of dopants concentration on energy transfer parameters. A series of non-linear ...

We demonstrate an all-fiber passive mode-locking laser operating in the 2 μm region that is implemented using a MoSe2-based saturable absorber (SA). A MoSe2-polyvinyl alcohol (PVA) SA is prepared with a modulation depth of 4.98%, a saturation intensity of 168.6 MW/cm2 and a nonsaturable loss of...