Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. They are generally well tolerated, but can cause insulin resistance in patients. Therefore, we investigated the mechanisms underlying the statin-induced insulin resistance.We used mice and C2C12 myotubes (murine cel...

Simvastatin is known as a pro-drug, which could be hydrolyzed by esterases to its active form, simvastatin acid. Although pharmacokinetics of simvastatin and simvastatin acid have been widely studied, hydrolysis of simvastatin to simvastatin acid during blood sampling and plasma preparation has ...

Previous research from our labs demonstrated the synthesis of polymerized simvastatin by ring-opening polymerization and slow degradation with controlled release of simvastatin in vitro. The objective of the present study was to evaluate the degradation and intramembranous bone-forming potential...

In the present work, inclusion complexes of simvastatin (SIM), atorvastatin calcium (ATV) with hydroxypropyl-β-cyclodextrin (HP-β-CD) have been prepared using mechanochemistry technique to improve solubility of the two drugs and enhance their oral bioavailability. The interactions of the drugs...

A simple, specific and accurate reverse phase liquid chromatographic method was developed for the simultaneous determination of Atorvastatin calcium and Nicotinic acid in tablet dosage forms. The analysis has been performed by using Agilent ZORBAX SB-C18 (150 × 4.6 mm, 3.5 u) and mobile phase c...

This study aimed to investigate the efficacy of combined atorvastatin calcium and methylprednisolone for the treatment of multiple sclerosis relapse. Patients with multiple sclerosis (MS) at the relapse phase were randomized to receive either combined treatment of atorvastatin calcium and methyl...

A rapid, selective and sensitive ultra high performance liquid chromatography coupled with tandem triple quaternary mass spectrometry (UHPLC-MS/MS) method was developed and validated for the quantitative determination of atorvastatin calcium (AC) in human plasma. Separation of AC and rosuvastati...

A simple, rapid and sensitive method for the determination of atorvastatin calcium in pharmaceutical preparations using two modified carbon paste electrodes was developed. One electrode (sensor A) is based on ion-pair of atorvastatin with 5,6-diaminouracil hydrochloride (ATS-DAUH) and the other ...

BackgroundIschemic heart disorders and accumulation of lipids in blood vessels could contribute to angina pectoris. Therefore, the aim of this study was to formulate sublingual tablets containing a novel combination of Atorvastatin calcium (ATOR) and Trimetazidine HCl (TMZ) for efficient treatme...

A biodegradable poly(lactic-co-glycolic acid) loading atorvastatin calcium (AC) nanoparticles (AC-PLGA-NPs) were prepared by probe ultrasonication and evaporation method aiming at improving the oral bioavailability of AC. The effects of experimental parameters, including stabilizer species, stab...

Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as hydrophilic carriers. This formulation was then ...

Many water bodies are being contaminated by atorvastatin, which has certain side effects and problems on healthy individuals through contaminated water. For this purpose, effective and selective carboxymethylcellulose macromolecule iron composite nanoparticles were synthesized by green methods, ...

Targeted drug delivery platforms can increase the concentration of drugs in specific cell populations, reduce adverse effects, and hence improve the therapeutic effect of drugs. Herein, we designed two conjugates by installing the targeting ligand GalNAc (N-acetylgalactosamine) onto atorvastatin...

The synthesis of two [Hg(L1)2] and [Hg(L2)2] complexes using asymmetric triazenes as ligands are reported. The triazene ligands are substituted with cyano and chloride groups in the ortho positions of the aryl rings (where HL1 and HL2 are 1-(2-ethoxyphenyl)-3-(2-cyanophenyl)triazene and 1-(2-eth...

A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI50 = 0.04 μM) and HL-60 (GI50 = 0.09 μM)...

The key dinitrile intermediates 4a–d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a–d. Suzuki coupling of 3a–d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidazo[1,2-a]pyridine derivatives 4a–d. The bis-amido...

Electrochromism and related devices have been studied for a few decades from both fundamental and technological point of view. At the present stage, screening electrochromic materials with excellent properties is still an interesting job. In our previous work, we have demonstrated that hydroxyal...

Dimethylaminobenzonitrile (DMABN) and N,N′-bis(4-cyanophenyl)piperazine (BCPPZ) have been comparatively studied by X-ray diffraction, fluorescence and time-resolved emission and absorption. BCPPZ can be considered as a pseudo-dimer made up of two weakly interacting DMABN moieties. The crystal s...

Two new pentamethylene-bridged bis-imidazolium dication ligands (L1 = 1,5-bis(1-(4-cyanophenyl)-imidazolium-1-yl)pentane dibromide) and L2 = 1,5-bis(1-(4-methoxyphenyl)-imidazolium-1-yl)pentane dibromide) bearing CPI (1-(4-cyanophenyl)-imidazole) and MPI (1-(4-methoxyphenyl)-1H-imidazole)-functi...

A series of six organotin(IV) carboxylates [Me2SnL2] (1), [Bu2SnL2] (2), [Oct2SnL2] (3), [Me3SnL] (4), [Bu3SnL] (5) and [Ph3SnL] (6), where L = 3-(4-cyanophenyl)-2-methylacrylate, have been synthesized and characterized by elemental analysis, FT-IR and NMR (1H, 13C). The ligand coordinates to ti...