The homopolymer of CHPM and its copolymers with styrene and divinylbenzene (DVB), prepared by addition polymerization, proved to be selective chelating ion-exchange polymers. The chelating ion-exchange properties of these polymers were studied for Ca2+, Cr3+, Fe3+, Ni2+, Cu2+, Zn2+, Cd2+ and Pb2...

Microorganisms were used to reduce ethyl 4-chloroacetoacetate (CAAE) to ethyl (S)-4-chloro-3-hydroxybutanoate [(S)-CHBE]. Mucor ramannianus provided 98% conversion with 84% ee. Free cells of Kluyveromyces marxianus led to 95% conversion with 81% ee. After a fractionary factorial design to study ...

A convenient method for the preparation of X-alkylated ethyl acetoacetate from alkyl halides via a new isoxazole enamine-salts is reported.

SummaryMetabolic plasticity has been linked to polarized macrophage function, but mechanisms connecting specific fuels to tissue macrophage function remain unresolved. Here we apply a stable isotope tracing, mass spectrometry-based untargeted metabolomics approach to reveal the metabolome penetr...

This paper examines the reversible enamine crosslinking reaction between poly-l-lysine (PLL) and poly (methacrylic acid-co-2[methacryloyloxy]ethyl acetoacetate) (70:30 mol%, A70), used to form crosslinked networks for cell encapsulation. Comparison of polymeric and small-molecule reactants showe...

Investigation of the reactions of potassium ethyl acetoacetate (KEAE) with C2H5X (X = Cl, Br, and I) in the gas-phase, tetrahydrofuran, and hexamethylphosphoramide was conducted at the B3LYP/6-311+G(d,p) level of theory. The C3- and O2-ethylations were examined to find out whether the Marcus or ...

A detailed physicochemical study has been carried out on tetracoordinated complexes of the type Ni[P(CH3)3]2X2 (X = CN−, NO2 −, NCS−, Cl−, Br−, I−, P(CH3)3).The experimental results (molecular weight, magnetic moment, conductivity, infrared, Raman and electronic spectroscopy) are in agreement wi...

In this article, a novel and efficient electrochemical sensor of creatinine was facilely constructed on the surface of multifunctional nanohybrids-modified glassy carbon electrode (GCE), integrating creatinine-induced specific signal response and enzymeless ratiometric signal detection strategy....

Complexes of five pyridines and nine pyridine N-oxides with 2,6-dichloro-4-nitrophenol (DCNP) in solution and the solid state were studied by Fourier transform IR and UV spectroscopy, by quantum-mechanical calculations with the semiempirical parametric method 3 (PM3) and by X-ray analysis.The cr...

During direct trifluoroethoxylation, both the 2-chloro group and the three fluoro groups of 2,5-dichloro-3-trifluoromethylpyridine were substituted by trifluoroethoxy groups. The product was characterized by mass spectrometry and by IR, 1H and 13C NMR spectroscopy. A possible reaction mechanism ...

2-Chloro-5-methylpyridine-3-olefin derivatives (3a-e) have been synthesized from 2-chloro-5-methylnicotinaldehyde (1) and studied their photochemical E (trans) → Z (cis) isomerization upon direct irradiation and triplet sensitized excitation for the first time. The triplet sensitized excitation...

Available methodology was adapted to synthesize a labeled diether analog of 2-phosphatidylcholine (1,3-di-O-9'-cis-[9',10'(n)-3H]octadecenylglycero-2-phosphocholine ([3H)DOE-2-PC). Unilamellar liposomes prepared by sonication from this phospholipid were injected into rats and, 4 h...

Synthesis and structural characterisation of novel fully protected muramic acid 2 (N-Boc-Mur-OMe, Mur = muramic acid) has been reported. N-Ac-Mur-OMe (1) prepared starting from commercially available N-acetylglucosamine, was treated with di-tert-butyl dicarbonate (Boc2O) and N,N-dimethyl-4-amino...

A new and mild synthetic approach for the synthesis of N-arylsulfonamides under copper-catalyzed conditions at room temperature has been developed. The reaction employs various tert-butyl N-sulfonylcarbamates and diaryliodonium salts to avoid potential genotoxic impurities. A one-pot coupling/Bo...

2,6-Disubstituted-3,5-dimethylpyrazines have been synthesized via biased acetal synthesis from symmetric 2,3,5,6-tetrakis(chloromethyl)pyrazine. The pyrazine ligands coordinated to trans-dichloropalladium(II) at the nitrogen whose neighboring carbons were connected to less hindered methyl groups...

A series of 2-(1,1-diphenylalkylamino)-1,3-diazaheterocycles was prepared and evaluated as antagonists of L-type calcium channels. Of the eighteen derivatives in this series, tetrahydropyrimidine 6h and hexahydro-1,3-diazocine 6n were the most potent calcium antagonists, being essentially equipo...

A complex of 5,5′-dibromo-2,2′-biphenol with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene hydroiodide has been studied by X-ray diffraction, FT-IR, and 1HNMR spectroscopy. In the crystal structure, the iodide anion is hydrogen-bonded to the MTBDH+ cation and to two hydroxyl groups of two 5,5′...

The photo-isomerization and photo-degradation of 2-hydroxy-5-methylbenzophenone (E)-oxime in ethanol, octane, toluene and a mixture of octane and toluene under exposure to daylight and UV light is studied. 2-Hydroxy-5-methylbenzophenone (Z)-oxime, 2-hydroxy-5-methylbenzophenone, 2-phenyl-5-methy...

The photo-isomerization and photo-degradation of 2-hydroxy-5-methylbenzophenone (Z)-oxime in ethanol, octane, toluene and a mixture of octane and toluene under an exposure to UV light is studied. The products of the photo-isomerization/photo-degradation are similar to those obtained during the p...

Three 2-phenyl-1,3-diazaazulene derivatives were synthesized and their protonation behaviours were investigated systematically via UV–vis absorption titration and 1H NMR titration, as well as theoretical calculations. One of them exhibited a monoprotonation process while the others displayed pr...