Objective: A multisite investigation compared the analytical performance of a point-of-care (POC) HbA1c device with multiple commonly used HbA1c laboratory methods and an NGSP (National Glycohemoglobin Standardization Program) reference method.Research Design and Methods: The Afinion AS100 POC d...

ObjectiveTo conduct a systematic review to assist the United States Secretary of Health and Human Services Advisory Committee on Heritable Disorders in Newborns and Children (SACHDNC) to determine whether Hemoglobin H screening should be included among the core recommended conditions for newborn...

BackgroundHemoglobin A1c (HbA1c) is used to monitor long-term glycemic control in individuals with diabetes, guide therapy, predict the risk of microvascular complications, and more recently to diagnose diabetes. An automated liquid-flow capillary electrophoresis method was recently developed to...

BackgroundThe importance of glycosylated hemoglobin A1c (A1c) control as part of comprehensive risk factor management in patients with stable ischemic heart disease (SIHD) and diabetes mellitus (DM) is controversial.

BackgroundGlycated hemoglobin (GHb), reported as HbA1c, is used as marker of long-term glycemia for diabetic patients. HbA1c results from boronate affinity methods are generally considered to be unaffected by most hemoglobin variants; this assumes comparable glycation of variant and non-variant ...

BackgroundHemoglobin C, D Punjab, E or S trait can interfere with hemoglobin A1c (HbA1c) results. We assessed whether they affect results obtained with 12 current assay methods.

BackgroundUnrecognized hemoglobinopathies can lead to measured hemoglobin A1c (Hb A1c) concentrations that are erroneous or misleading. We determined the effects of rare hemoglobin variants on capillary electrophoresis (CE) and HPLC methods for measurement of Hb A1c.

A previously undescribed hemoglobin variant, hemoglobin Columbia Missouri, α88 (F9) Ala→Val, was detected in a 22-year-old white man who was undergoing assessment for erythrocytosis. This new hemoglobin variant does not separate from hemoglobin A by electrophoresis in conventional media, by is...

Differential editing of transcripts from the Newcastle disease virus (NDV) phosphoprotein gene results in mRNAs capable of encoding the phosphoprotein (P), the V protein, and the W protein which share a common N-terminus but specify different C-termini. Whereas the expression and viral incorpora...

In the mammal, melatonin regulates the seasonal and/or circadian rhythm of PRL levels. Since several members of the PRL gene family are expressed during late pregnancy, we investigated the relationship between the expression of placental lactogen (PL)-II-one member of the PRL family- and melaton...

A gene, sirZ, encoding a Zn(II)2Cys6 DNA binding protein is present in a cluster of genes responsible for the biosynthesis of the epipolythiodioxopiperazine (ETP) toxin, sirodesmin PL in the ascomycete plant pathogen, Leptosphaeria maculans. RNA-mediated silencing of sirZ gives rise to transform...

Protamine-like proteins (PL-II, PL-III and PL-IV) represent the major basic nuclear component of Mytilus galloprovincialis L sperm chromatin. The present study investigates the effects induced on the properties of PL-II protein after exposure of Mytilus galloprovincialis L for 24 h to 1.5 and 5 ...

Three 2-(morpholin-4-yl)ethoxy-substituted phthalocyanines with zinc(II) or magnesium(II) ion in the core were subjected to optical and photochemical studies, and their photodynamic activity against oral cancer cell lines was evaluated. Phthalocyanine derivatives were studied both as free compou...

The endogenous oxysterol 22(R)-hydroxycholesterol (22RHC, 1) is an LXR agonist which upregulates genes of critical involvement in human cholesterol- and lipid metabolism. In contrast, its synthetic epimer 22(S)-hydroxycholesterol (22SHC, 8) has shown specific antagonistic effects in recent studi...

1,7,7-Trimethyl-3-(pyrid-2-ylmethyl)bicyclo[2.2.1]heptan-2-ol 4 and its 2-phenyl, 2-methyl and 2-butyl analogs 5–7 were synthesized, characterized and used as ligands for the addition of diethylzinc to benzaldehydes. Best results were attained with 5 mol% of amino alcohol trans-4 (2-exo,3-endo)...

The activation and selectivity are the challenging problems always existing in the utilization of methanol as C1 resource. Herein, a novel cobalt complex catalyzed process for preparation of methyl acrylate from methyl acetate and methanol at 50 °C–80 °C was firstly developed. Such cobalt com...

This work reports an experimental and computational study on the autoignition characteristics of methyl propanoate under high pressure and low-to-intermediate temperature conditions. Comparisons to its next higher and lower methyl esters are also presented. The methyl propanoate experiments have...

The effect of sporicidal fumigation with methyl bromide or methyl iodide on the functionality of valuable electronic equipment was evaluated using desktop computers as surrogates under target conditions of 200–250 mg/L fumigant for 48 h at 24–30 °C and 75–85% RH. Methyl iodide fumigation dam...

A new, concise, and efficient route for the synthesis of 1-aminoisoquinolines in good to excellent yields is described; this involves the reaction of 2-alkynylbenzaldoximes and isothiocyanates, which is catalyzed by silver triflate in dichloromethane, at room temperature. This transformation inv...

The Raman and infra-red spectra of a series of aliphatic and aromatic isothiocyanates (mustard oils) have been measured. Analysis of the spectra enables two frequencies to be identified for each compound which are characteristic of an aliphatic or an aromatic NCS grouping. It is shown why the co...