Bis(2-hydroxybenzylidene)acetone is a potent inducer of the phase 2 response through the Keap1-Nrf2-ARE pathway. This double Michael reaction acceptor reacts directly with Keap1, the sensor protein for inducers, leading to enhanced transcription of phase 2 genes and protection against oxidant an...

Results from a theoretical study on hexaethynylbenzene (HEB) by MNDO and ab initio (STO-3G) molecular orbital methods are reported. The calculated geometry is in good agreement with the X-ray structure of the hexa-silylated derivative. The molecule HEB has a calculated ionization potential of 8....

The present study revealed that a climate regime shift occurred during the 1988–1991 period involving changes in tropical cyclone (TC) intensity (central pressure, maximum sustained wind speed) during the summer near 30°N in East Asia. Climatologically, TC intensity at 110°–125°E near 30°N...

The magnetic property and electronic properties such as ionization potentials and electron affinities of the Nin (n ⩽ 30) neutral and ionic clusters have been studied using the density functional theory calculations with the PBE exchange–correlation energy functional. The variations of the calc...

The present study focuses on the investigation for discrimination of the aerosol types using the curvature effect of Ångström exponent for different areas within the region of interest (88°-98° E and 20°-30° N). There are very few studies on aerosol optical properties and on the size distrib...

BackgroundIt is important to study the incidence and causes of readmissions in order to understand why they occur and how to reduce them. This study looks at a national sample of patients following total knee arthroplasty (TKA) to identify incidences, trends, causes, and timing of 30-day readmis...

Density functional theory (DFT) and time dependent density functional theory (TDDFT) at PBE0/6-311G* level are performed to examine the stability, electronic and optical properties of boron fullerenes (Bn, n = 20, 30, 38, 40, 50, 60). Amongst all the structures, B50 is found to be highly stable ...

The reaction of indolin-2-ones with CAN is studied. When the reaction is carried out in an alcohol as solvent, 3-alkoxyindolin-2-ones are obtained in very good yields. If a non-nucleophilic solvent is used (THF, acetonitrile) 3-nitroxy derivatives are isolated. If the aromatic ring bears an elec...

Indium(III) chloride was found to be an efficient catalyst for the synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-ones by one-pot, three-component reaction of dimedone, 1H-pyrazol-5-amines and isatins in water under ultrasonic irradiation. The a...

An automated pre-column high-performance liquid chromatographic method has been developed for the isolation of adibendan and metabolites from biological fluids and for their simultaneous quantitative assay. High sensitivities were obtained by the use of a multiple-injection device allowing solid...

We report the asymmetric catalysis mediated by a newly isolated strain from soil, Klebsiella oxytoca, for the preparation of the chiral intermediate of antiviral agent lamivudine which is proven to be one of most potent medicines for the treatment of human chronic hepatitis B and HIV infection. ...

Background and study aimsMother-infant hepatitis B virus (HBV) transmission is the current leading cause of chronic infection. We aimed to assess the efficacy of lamivudine use in hepatitis B surface antigen (HBsAg)-positive pregnant women to decrease viral load and thus aid in the prevention of...

Reactions of 6-(tri- and 6-(difluoromethyl))comanic acids with aniline, o-phenylenediamine and o-aminophenol were investigated. RF-containing derivatives of 4-pyridones, benzodiazepines and quinoxalinones were synthesized. Electrophilic properties of 6-(trifluoromethyl)comanic acid were evaluated.

The influence of horizontal distribution of conjugated poly(3-hexylthiophene) (P3HT) and insulating Poly(methyl methacrylate) (PMMA) on the dispersion and crystallization of organic semiconductor bis(triisopropylsilylethynyl) pentacene (TIPS pentacene) has been studied in this research. Within t...

Clofarabine triphosphate is an intracellular active metabolite of clofarabine. In the present study, we developed and validated a rapid, sensitive, and selective liquid chromatography–tandem mass spectrometry method (LC–MS/MS) for quantifying clofarabine triphosphate concentrations in human pe...

Purine nucleoside analogues are widely used in the treatment of haematological malignancies, and their biological activity is dependent on the intracellular accumulation of their triphosphorylated metabolites. In this context, we developed and validated a liquid chromatography tandem mass spectr...

Five analogues of 3‐quinuclidinyl benzilate were prepared in which one phenyl ring was substituted by a heterocycle; a bromine was included on either the remaining phenyl or the heterocycle to provide information relating to the affinity of potential radiohalogenated derivatives. Their affiniti...

The survival of tissues distal to major arterial occlusions is critically dependent on the development of collateral blood vessels. The biochemical events fundamental to their evolution remain undefined. To determine the role of endogenous basic fibroblast growth factor in the development of the...

Moraxella catarrhalis is a Gram-negative aerobic diplococcus that is a mucosal pathogen of the upper and lower respiratory tracts in humans. In order to colonize the human host and establish an infection, M. catarrhalis must be able to effectively attach to the respiratory mucosal epithelia. Alt...

Effluent from tannery industries can significantly affect the aquatic environment due to the presence of a variety of recalcitrant components. The present study focuses on a comparative assessment of the toxic impacts of an untreated tannery effluent and membrane treated effluents using snail, P...