In this paper, Cu2+ functionalized Fe3O4@polydopamine core-shell (Fe3O4@[email protected]2+) magnetic microspheres were prepared by the chelation between Cu2+ and catechol of polydopamine surface. The synthetic magnetic adsorbent was characterized by Fourier transform infrared spectroscopy, ener...

White cells were collected from the wash of rat pleural cavity after exsanguination. The incubation mixture of the pleural cells with 1 μM phorbol myristate acetate (PMA) was extracted with acidified ethanol and purified with a Sep-pak C18. The resultant fraction containing prostaglandins (PG) ...

A sensitive and selective high-performance liquid chromatographic method was developed for the determination of SK&F 106203 3-(2-carboxyethylthio)-3-[2-(8-phenyloctyl)phenyl]propanoic acid, a potent peptidoleukotriene end organ receptor antagonist, in human plasma. The method involves isolation ...

Arachidonic acid (AA) metabolites produced by washed human platelets and rat macrophages were analyzed by high-performance liquid chromatography (HPLC) using a pre-column derivatization method. The reagent, 9-anthryldiazomethane, used in this study and AA metabolites derivatized by the reagent w...

A high-performance liquid chromatographic technique for the rapid assessment of fatty acids in cardiac tissue is described. A level of 50.4 ± 14.9 nmol fatty acids per g wet weight of rat myocardial tissue could be monitored. The content of the individual fatty acids C14:0, C16:0, C16:1, C18:0,...

Application of a method for the “in situ” generation of 9-anthryldiazomethane (ADAM) to the derivatization of the carboxyl function in diarrhetic shellfish poisoning (DSP) toxins revealed the formation of artifact products. Using liquid chromatography–mass spectrometry, it was determined that...

The high-performance liquid chromatographic determination of carnitine chloride was investigated by using 9-anthryldiazomethane (ADAM) as a pre-column derivatization reagent. Carnitine chloride and the internal standard N,N-dimethylglycine reacted with ADAM to give a stable ester derivative in t...

A preparation method for 9-anthryldiazomethane (ADAM) as a fluorescent labeling reagent for carboxylic acids is described. 9-Anthraldehyde hydrazone is oxidized with an organic oxidant, N-chlorosuccinimide, in an organic solvent such as ethyl acetate to give ADAM, and then the reaction mixture i...

Nieotinylcholine and three related bisquaternary derivatives, nicotinylcholine iodide methiodide, nicotinylhomocholine iodide methiodide and pyridyl-3-acetycholine iodide methiodide, have been synthesized and studied pharmacologically. Nictinylcholine is in general less potent than naturally-occ...

An angucycline series compound P371 A1 (1) from Streptomyces sp. P371 was established to have a novel structure comprising an ureido group at one of four sugar units on the basis of 2D NMR techniques. 1 exhibited an inhibitory activity against the pentagastrin-stimulated acid secretion as well a...

The antigastrinic activity, in vivo, of CR 2194 (R-4-(3-chlorobenzamido)-5(8-azaspiro[4.5]decan-8-yl)-5-oxo pentanoic acid) was assessed in various animal species. CR 2194 antagonized pentagastrin-stimulated gastric acid secretion in the rat (ID50 = 11 mg/kg i.v.), dog (ID50 = 5.9 mk/kg i.v. or ...

The extraction separation behaviour of Fe(III), Co(II), Ni(II) and Cu(II) from aqueous solutions of various pH values and complexing agents using 1-phenyl-3-methyl-4-(p-nitrobenzoyl)-5-pyrazolone has been investigated. The possible extraction mechanism and the compositions of the extracted speci...

When ortho-nitrated benzoic acids are chlorinated in xylene and acetonitrile, the product gases, HCl and SO2, dissolve in the solvent mixture. Previously measured solubilities [Lever, S. D., Papadaki, M. (2004a). o-Chlorination of 2-nitrobenzoic acid with thionly chloride in xylene and acetonitr...

The influence of temperature on the solvolysis of substituted benzoyl chlorides in the presence of dimethyl-β-cyclodextrin (DM-β-CD) was studied. Based on the influence of the DM-β-CD concentration on chemical reactivity in this process, the cyclodextrin has a catalytic effect on the solvolys...

Hydrazones (HL) derived from N-(p-toluenesulfonyl)-3-acetylpyrrole with acetylhydrazine, methyl carbazate, and semicarbazide were cyclopalladated with lithium tetrachloropalladate in the presence of sodium acetate in methanol to give [PdClL]. The complex (HL=acetylhydrazone) reacted with a ligan...

N-Methyl-N-[(1S)-1-(4-isophiocyanatophenyl)-2-(1-dyrrolidinyl)ethyl-3,4-dichlorophenylacetamide (MITPD)1, is an isothiocyanate derivative of the κ agonist ICI-199,441. In this study, interaction of MITPD with cloned μ, δ, and κ opioid receptors was characterized. MITPD inhibited [3H]diprenor...

A series of novel cholinesterase inhibitors containing nitrobenzoate core structure were synthesized by a facile and efficient method. The structure of the novel compounds were fully characterized and confirmed by analytical as well as spectroscopic methods. Compound indicated as 2f was found to...

Regioselective hydroxysulfenylation of unactivated CC double bonds was reported. Using FeBr3-bpy as the catalyst, Na2S2O8 as the oxidant, and sulfonyl hydrazides as the sulfenyl sources, hydroxysulfenylation of unfunctionalized olefins proceeded readily, giving a variety of β-hydroxysulfides in...

Phase separation rate is a critical character in determining the usefulness of a solvent extraction system in hydrometallurgy. A survey of the synergistic mixture containing dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexly 4-pyridinecarboxylate ester (4PC) for the extraction of cobalt f...

In this study, a pilot plant Oldshue–Rushton extraction column has been proposed to extract and recover cobalt from sulfuric acid leach solution. The effect of D2EHPA and TBP concentration, initial aqueous pH and stripping solvent on the Co(II) extraction was investigated in the batch experimen...