The reaction of europium(iii) or terbium(iii) chlorides with ethyl 2-hydroxymethylidene-3-oxobutanoate in the presence of 2,2’-bipyridine (2,2’-bipy) resulted in the luminescent complexes [LnL3]·2,2’-bipy (L = ethyl 2-hydroxymethylidene-3-oxobutanoate, Ln = Tbiii or Euiii), whose molecular s...

A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8–21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl esters (2–7) with different alkyl or aralkyl halides in the presence of a combination of anhydrous K2CO...

Series of 3-benzylsulfanyl derivatives of 1,2,4-triazole and 4-methyl-1,2,4-triazole were synthesized by alkylation of starting triazole-3-thiol with appropriately substituted benzyl halide. All members of the set were evaluated for in vitro antimycobacterial activity against Mycobacterium tuber...

Successive reaction of α-amidomethyl sulfones 7a,b, derived from primary amides, with n-butyllithium and primary alkyl bromides (CH2CHCH2Br, CH2CMeCH2Br, CH2CBrCH2Br, CHCCH2Br, PhCH2Br, ButO2CCH2Br) at −90°C yields, after hydrolysis, enamides 11. The same procedure applied to α-amidom...

This article describes the synthesis of a series of butyrophenone analogues in which the propyl chain is partially included in a cyclopentane ring. These trans-(2-aminomethyl)cyclopentyl aryl ketones are obtained by reacting (2-bromomethyl)cyclopentyl phenyl ketone or (2-bromomethyl)cyclopentyl ...

An efficient one-pot synthesis of quinazolin-4(3H)-ones, benzoimidazo[2,1-b]quinazolin-12(6H)-ones and imidazo[2,1-b]quinazolin-5(1H)-ones via a palladium-catalyzed domino process has been developed. The Pd-catalyzed reactions of 2-azidobenzamides 1 with isocyanides 2 produced quinazolin-4(3H)-o...

The CuI-catalyzed domino reaction between 1-(2-bromophenyl)methanamines and amidines using K3PO4 as the base, pivalic acid as the additive, and aerial oxygen as the oxidant gives access to substituted quinazolines in a single step with yields in the range between 43 and 90%. It is assumed that t...

An optimization of a modified Grimmel's method for N-heterocyclization of Leucine linked sulphonamide leading to 2,3-disustituted-4-quinazolin-(3H)-ones was accomplished. Further, nineteen hybrid quinazolinone motifs (5a-5s) were synthesized by N-heterocyclization reaction under microwave i...

We earlier reported an in silico pharmacophore model for reactivation of oximes to tabun-inhibited AChE. Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a rational strategy to discover non-oxime reactivators of DFP-inhibited AChE in this study. ...

Thermolysis of N-arylnicotinamide oximes 1a–c (R =  H, CH3 and Cl) under nitrogen gives rise to benzimidazoles 3a–c as the major products (60–62%), in addition to nicotinonitrile 4, arylamines 5a–c, nicotinic acid 6, phenols 7a–c and 8a–c, nicotinanilides 9a–c, 2-(pyridin-3-yl) benzoxazol...

A new and easy-to-perform route to 2-oxazolines amd isoxazolines was reported. Using CuBr2 as both the bromide source and the reaction promoter, bromocyclization of N-allylamides and allyl ketone oximes proceeded readily, leading to oxazolines and isoxazolines in good to excellent yields.

Aliphatic oxime derivatives C7H15CXNOH (X = H, CH3, NH2 or OH) have been commercially used as copper(II) extractants or flotation collectors, but the true nature of their reactivity toward Cu2+ or mineral surfaces still remains elusive. Using density functional theory (DFT) method, the structure...

The FT–IR (4000–400 cm−1) and FT–Raman (4000–100 cm−1) spectral measurements of benzamide oxime and complete assignments of the observed spectra have been proposed. Ab initio and DFT calculations have been performed giving energies, optimized structures, harmonic vibrational frequencies, dep...

This study focuses on the covalent grafting of thin organic layers on a glassy carbon electrode by aryl diazonium salts containing functional groups capable of complexing Ni(II) ions. The goal was to develop a modified electrode for the detection of Ni(II) ions in aqueous media. The glassy carbo...

This work aimed to study the phenolic acid metabolism of sourdough lactic acid bacteria (LAB) in laboratory media, and in sourdough fermentation with single cultures and in co-fermentations. Lactobacilli were selected from isolates obtained from 35 sourdough samples. Isolates (114 strains) were ...

The profiles of phenolic compounds and antioxidant properties of dehulled foxtail millets were studied. Twenty-one phenolics were detected in the free fraction, including a series of nine hydroxycinnamic acid spermidines reported for the first time and three flavonoid C-glycosides of kaempferol ...

This study aimed to establish a precise HPLC-MS approach to determine the concentrations and distribution of major phenolic acids in six categories of vegetables that are commonly consumed in China. We detected 17 phenolic acids within 15 min under optimized conditions. The method showed detecti...

Free and bound phenolic acids were measured in the pulp and peel of four varieties of apples using high resolution mass spectrometry. Twenty-five phenolic acids were identified and included: 8 hydroxybenzoic acids, 11 hydroxycinnamic acids, 5 hydroxyphenylacetic acids, and 1 hydoxyphenylpropanoi...

2-(3′,5′-Dimethoxybenzylidene) cyclopentanone (DMBC) is a novel small-molecule compound synthesized by our group. Here, we found that in rat models of permanent middle cerebral artery occlusion (pMCAO), intraperitoneal injection (ip) of DMBC at 1 h after ischemia reduced infarct volume, improv...

Three bis(arylmethylidene)cyclopentanone dyes were synthesized and their structures and properties elucidated using single-crystal X-ray diffraction, mass spectrometry, 1H nuclear magnetic resonance, IR and UV–Vis spectroscopy. X-ray analyses revealed that two were monoclinic, with space group ...