Multifunctional 2-aminobenzimidazoles were directly synthesized through sequential addition of N-substituted o-diaminoarenes to isothiocyanates, formation of carbodiimides via I2-mediated oxidative desulfurization, and intramolecular cycloaddition. This efficient and eco-friendly synthetic proce...

SummaryGABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits. The structure and function of GABAergic synapses are sensitive to destabilization by impinging neurotransmitters. However, signaling mechanisms ...

X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disorder endemic to Panay Island (Philippines). Patients present with generalizing dystonia and parkinsonism. Genetic changes surrounding the TAF1 (TATA-box binding protein associated factor 1) gene have been associated with XDP inducin...

Astaxanthin (AST) is a carotenoid that has been shown to have neuroprotective effects. In this study, it was found that AST significantly inhibited glutamate-induced loss of cell viability and apoptosis. AST pretreatment attenuated glutamate-induced activation of caspase-3, reduction of anti-apo...

In vivo chemical analysis is an important aspect in exploring brain functions. Brain function realization depends on multiple chemical molecules working together. The determination of one single chemical substance is difficult to clarify the signal transduction and disease occurrence. Thus, it i...

GLT-1 is the main glutamate transporter in the brain and its trafficking controls its availability at the cell surface, thereby shaping glutamatergic neurotransmission under physiological and pathological conditions. Extracellular glutamate is known to trigger ubiquitin-dependent GLT-1 internali...

Publisher SummaryThis chapter discusses the prazosin hydrochloride. Prazosin hydrochloride was synthesized and developed by the Medicinal Chemistry Laboratories of Pfizer Inc. Prazosin hydrochloride was introduced as a novel antihypertensive agent with pharmacological activity attributed to arte...

The three-dimensional solid-state structures of prazosin hydrochloride, C19H22N5O4+ · Cl− (A), and prazosin free base, C19H21N5O4 (B), have been determined by synchrotron X-ray powder diffraction. A and B crystallize in triclinic P-1 and monoclinic Cc space groups, respectively, with one struct...

Nalbuphine, a partial agonist/antagonist opioid analgesic, is structurally related to morphine. It is equipotent to morphine and has no serious side effects. In the past few decades, studies focusing on morphine metabolism have indicated that one of its sugar-conjugated metabolites, morphine-6-g...

Titanium dioxide with and without the addition of neodymium ions was prepared using sol–gel and precipitation methods. The resulting catalysts were characterized by thermal analysis, X-ray diffraction and BET specific surface area. Neodymium addition exerted a remarkable influence on the phase ...

In the present study, TiO2 and Nd doped TiO2 nanoparticle was synthesized through Sol-gel method with different molar ratio and different starting material. The synthesized nanoparticle was characterized by XRD, UV-Vis, PL, FE-SEM, HR-TEM, and EDS analysis. The X-ray diffraction pattern confirms...

This work is devoted to study of the spectral properties of hybrid materials based on silica and adducts of Nd(III) tris-β-diketonates and 1,10-phenanthroline as promising UV-light converters for optical amplifiers and waveguides, lasers, solar cells etc. It was shown that covalent grafting of ...

Reaction between neodymium chips and isopropanol led to the isolation of [Nd(OiPr)3]4·4iPrOH. Its desolvation results in a soluble polynuclear neodymium(III) oxoisopropoxide, whose reactivity has been investigated. Reaction with acetylacetone produced a compound analysing as Nd2(OH)(acac)5, whi...

The neodymium complexes with nitrogen and oxygen donor pyrazoline ligands were synthesized by the conventional method. To observe the effect of the change in environment, the mixed ligand complexes along with pure neodymium-pyrazoline complexes were synthesized. Shelf-life of these newly synthes...

Bismuth potassium titanate (Bi0.5K0.5TiO3; BKT) and praseodymium-doped BKT (Bi0.5(1−x)PrxK0.5TiO3; BPKT) powders were synthesised using the soft combustion technique. Fine particles of 10–100 nm of BKT and BPKT were produced. A single phase BKT was obtained with a minimum of 0.5 mol of glycine....

Bimetallic alkoxides of praseodymium and neodymium with aluminum, viz., M[Al(OC3Hi7)4]3, where M = Pr(III)/Nd(III), have been used as catalysts in Meerwein–Ponndorf–Verley (MPV) reduction of 2-octanone and benzophenone in isopropanol to give their corresponding secondary alcohols. The reductio...

Nanocrystalline TiO2 incorporated with praseodymium(III) nitrate has been prepared by an ultrasound method in a sol–gel process. The prepared sample is characterized by X-ray diffraction (XRD), nitrogen adsorption (BET surface area), UV–vis diffuse reflectance spectroscopy (UV–Vis DRS) and X-...

5-Methyl-2′-deoxycytidine (5-mdC), 5-hydroxymethyl-2′-deoxycytidine (5-hmdC), 5-methylcytidine (5-mrC) and 5-hydroxymethylcytidine (5-hmrC) are epigenetic marks of DNA and RNA, and aberrant levels of these modified nucleosides were found to be associated with various cancers. Urine is a prefer...

Both DNA cytosine methylation (5-methyl-2’-deoxycytidine, m5dC) and RNA cytosine methylation (5-methylcytidine, m5rC) are important epigenetic marks that play regulatory roles in diverse biological processes. m5dC and m5rC can be further oxidized by the ten-eleven translocation (TET) proteins t...

N-Substituted maleimides have been investigated as thermal stabilizers for plasticized PVC at 180°C in air by measuring the rate of dehydrochlorination and the extent of discoloration of the degraded polymer. The results reveal a higher stabilizing efficiency of the products investigated compar...