Novel nojirimycin-derived bicyclic structures, containing cyclic carbamate, urea and guanidine moieties have been synthesised starting from suitably protected α-C-vinylnojirimycin and α-C-allylnojirimycin, respectively, and their biological activity against different glycosidases and as antiba...

Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This part concerns the catechol moiety of the A-ring as well as the 2,3,...

The structure of 13-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-16β,17-diol (3, 16β-OH desogestrel), a by-product obtained in the last step of the synthesis of desogestrel (1) by reaction of monolithium acetylide-ethylenediamine complex with 13β-ethyl-11-methylenegon-4-en-17-one (2),...

Six new diterpenoids of the rare phyllocladane (13β-kaurane) type have been isolated from Plectranthus ambiguus. Their structures were determined on the basis of their spectral properties and by correlation with 16R,17-dihydroxyphyllocladane-3-one (calliterpenone).

The syntheses of three 17α-acetoxy-13β-ethyl-11β-aryl-18,19-dinorpregna-4,9-diene-3,20 diones from levonorgestrel are described. Despite their close structural similarity to the antiprogesterone CDB-2914, one of the compounds exhibits agonistic progestational activity, and the other two compo...

Two new macrocyclic ligands, L1 (14-membered N2O2) and L2 (28-membered N4O4) from [1+1] and [2+2] condensation, respectively, have been obtained in a one-pot synthesis starting from 1,4-bis(2′-formylphenyl)-1,4-dioxabutane and cis-1,2-diaminocyclohexane.Both ligands were synthesized in the same...

A novel series of non-peptide proteasome inhibitors (PIs) that act on chymotrypsin-like (ChT-L) of the proteasome were developed. These PIs bearing 4-aromatic sulfonyl naphthalene-based scaffold and Leu-boronic moiety as covalent bonding group displayed far better activity than PI-8182 for inhib...

Bio-based fuels are becoming more and more important due to the depleting fossil resources. The production of biodiesel from algae oil is challenging compared to terrestrial vegetable oils, as algae oil consists of polar fatty acids, such as phospholipids and glycolipids, as well as non-polar tr...

In this work, the Aleurites moluccanus oil was obtained in high yield from the almonds (42%). The methyl and ethyl esters obtained by transesterification of the oil, have a high content of fatty acid unsaturated esters (>89%). Thermal properties in inert and oxidative atmospheres of oils and est...

The present experimental study is investigated on Kirloskar make TAF-1 model CI engine powered by Garcinia gummi-gutta methyl ester (GGME) biodiesel and its blends with mineral Diesel. Biodiesel is conceived from Garcinia gummi-gutta seed oil via novel immobilized lipase transesterification and ...

Yucca aloifolia Linn (Y. aloifolia) is a drought-resistant arid land plant that grows in most soil types. In this work, Y. aloifolia seed oil (YAO) was evaluated for the first time as a potential biodiesel feedstock, which contains 16.23% oil (w/w) whereas the acidity of the oil was 11%. Two ste...

Gd2O3:Er3+ nanophosphors were fabricated by the combustion method in presence of Na2 ethylene diamine tetra acetic acid (EDTA-Na2) as fuel at not high temperature (≤350 oC) within a very short time of 5 min. The added concentration of Er3+ ions in Gd2O3 matrix was changed from 0.5 mol% to 5.0 m...

ObjectiveTo determine if gadolinium (Gd) can be rechelated once released from Gd-based contrast agents (GBCAs) and deposited in vivo. Despite extensive research comparing GBCAs and GBCA formulations as well as the ongoing debate about their risks of deposition and the role of Gd release, it rema...

Earlier the monotonic increase of the free energy of chemical exchange processes along the series of lanthanide [Ln(H2O)n(EDTA4−)]− complexes was found [Babailov S.P., Magnet. Reson. Chem., 2012, 50, 12, 793] for the yttrium subgroup (Tb3+, Ho3+, Tm3+, Yb3+ and Lu3+). In the present paper 1H NMR...

The methodology and published work aimed at speciation of gadolinium based contrast agents in tissues is reviewed. The discussion focusses on the context of Gd deposited long term in tissue following administration of the contrast agents. Detection of Gd without identification of the chemical fo...

This summary attempts to provide forward-looking concepts regarding gadolinium related toxicity, as discussed in further detail in this issue.

Gadolinium-based contrast agents used in magnetic resonance imaging are difficult to impossible to remove in wastewater treatment plants, and may enter groundwater production wells and hence municipal tap water via bank filtration. As anthropogenic gadolinium (Gd) may be accompanied by other, mo...

In the present study, gadolinium doped ceria (Ce0.8Gd0.2O2−δ, GDC) electrolytes at different pH have been successfully prepared by EDTA-citrate complexing method for intermediate temperature solid oxide fuel cells (IT-SOFCs). XRD, Raman, FE-SEM, TEM and electrochemical impedance spectroscopy ar...

Gadolinium based contrast agents (GBCAs) play an important role in the diagnostic evaluation of many patients. The safety of these agents has been once again questioned after gadolinium deposits were observed and measured in brain and bone of patients with normal renal function. This retention o...

The catalytic efficiency and selectivity of a series of manganese(III) complexes of meso-tetrakis(pentafluorophenyl)porphyrin H2(TPFPP) derivatives bearing one to four ethylene glycol moieties are compared in the oxidation of cis-cyclooctene and cyclohexane in the presence of H2O2 at ambient tem...