The infrequent manifestation of SIRT1 and Aurora B kinase has shown to play a pivotal role in colorectal cancer (CRC) progression by regulating Wnt signaling pathway. The present study investigates the signaling events that regulate the modulation of SIRT1 and Aurora B kinase expression and it’...

BackgroundGliomas are the most aggressive malignant tumors of the central nervous system. The diphenyl diselenide [(PhSe)2] is an organoselenium compound that has multiple pharmacological properties. Previous reports showed that (PhSe)2 nanoencapsulation potentiates its in vitro antitumoral acti...

Effects of two salt additives, NaCl and NaClO4, at the fixed concentrations of 0.215 M on the properties of aqueous two-phase systems (ATPSs) formed by dextran (Dex) and polyethylene glycol (PEG), and the effects of NaClO4 at the same concentration on the properties of ATPS formed by PEG and Na2...

A series of covalently cross-linked sulfonated poly(imide benzimidazole)s (CBrSPIBIs) were synthesized using 4,4′-bibromomethenyl diphenyl ether as a cross-linker. However, the cross-linked structure results in a reduction of ion conductivity due to the blockage of the hydrophilic channel. Thus...

The extraction process involving enzymatic treatment and salting-out extraction was developed to accelerate dissolution of flavonoids from the hard compact seeds of Cuscuta chinensis Lam. A combination of enzymes (cellulase and protease) provided higher flavonoid yields than single enzyme. The o...

A new reactive material (Fe-GAC) was synthesized and tested by impregnating various iron salts on granular activated carbon for perchlorate removal from water. SEM, FTIR and XRD characterization of Fe-GAC revealed that Fe-GAC had different morphology or structure and NO3−, SO42− or Cl− attached....

Reaction of acetylacetone-S-methyl-thiosemicarbazone and 4-methoxy-salicylaldehyde in presence of Fe(ClO4)3 and NaN3 resulted in a mixed ligand complex, [Fe(L)N3], where L is N2O2-chelating thiosemicarbazidato ligand formed by template condensation. The first iron complex of the thiosemicarbazid...

Structural and electronic properties of [cis-[Cr(tmpcH)X2]n+ (n = 2 or 4; X = OH−, Cl−, Br− and H2O; tmpcH = 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane were analyzed by DFT and TD-DFT methods. The local reactivity active site of the ligand was determined by the condense...

The new hybrid compound “Bis-2-amino-4-picolinium tetrachloro-mercurate-zincate ((C6H9N2)2(Hg0.12Zn0.88)Cl4)” was prepared by hydrothermal method using HCl as solvent and characterized by XRD, NMR-MAS 13C and electrical impedance spectroscopy. The XRD reveals that the compound was crystallized...

Three isotype compounds; (C6H9N2)2HgCl4 (I), (C6H9N2)2(Hg0.75Cd0.25)Cl4 (II) and (C6H9N2)2(Hg0.12Zn0.88)Cl4 (III), have been obtained by hydrothermal method using HCl as solvent and characterized by single-crystal X-ray diffraction at room temperature. There are crystallized in a triclinic syste...

Ferroic crystals of tetramethyl ammonium tetrachlorozincate (TMA-ZnCl) were grown by slow evaporation technique and the morphology of the grown crystals varies with different pH values. The compound crystallizes in orthorhombic primitive system at room temperature with non-centro symmetric space...

14-3-3 proteins are a type of highly conserved acidic proteins, which are distributed over a wide variety of organisms and are involved in multiple cellular processes. While the comparative and evolutionary analysis of this gene family is unavailable in various fish species. In this study, we id...

Pyruvate kinase (PYK) is an important enzyme in the intermediary metabolism and has attracted much attention as a target for metabolic engineering of Corynebacterium glutamicum. Genome sequencing revealed that the 308 residue of PYK was mutated from methionine in model strain C. glutamicum ATCC1...

d-Serine is considered a key endogenous substance involved in several enzymatic reactions in the human body. In this study, solid-state vibrational circular dichroism (VCD) measurements of enantiomeric serine were performed for spectroscopic distinction between d- and l-serine. The mirror-image ...

Schistosomiasis, caused by trematodes of the genus Schistosoma, remains an important public health issue. Adult schistosomes can survive in the definitive host for several decades, although they are subject to the host immune response. Consequently, understanding the mechanism underlying worm su...

Although L-Serine has wide applications and great market potential, its application is limited by its high cost and low yields. Microbial factories have many advantages for producing L-serine from renewable carbon resources. To achieve L-serine production with high efficiency, three enzymes (Ser...

Citrus pectin (CP14) from Citrus sinensis, and a fucogalactan (E) and a glucan (G16) from Agaricus bisporus were isolated and structurally characterized. CP14 was constituted by (1→4)-linked α-d-GalpA units, E was composed by a (1→6)-linked α-d-Galp main-chain, partially substituted at O-2 b...

A mild, catalytic method for the synthesis of 3-carboxy-2,5-disubstituted furans is reported proceeding via a 5-exo-dig cycloisomerization reaction. The iron(III) chloride-catalyzed transformation of aryl- and alkyl β-ketoesters enables synthetic access to functionalized furan core structures f...

The kinetic properties of cholinesterase (ChE) present in plasma were compared with those of purified human ChE using the substrates succinyldithiocholine (SDTCh), acetylthiocholine (AcTCh) and butyrylthiocholine (BuTCh). SDTCh was hydrolysed at two sites; a site with a low Km (Km1 11.4 ± 3.3 μ...

Several metals were found to catalyze the conversion of benzotrifluoride to benzoyl fluoride in the presence of carboxylic acids and sulfonic acids, together with the corresponding anhydride, and molecular oxygen. Nb2O5 exhibited the highest activity, and a conversion of ∼99.8% and a selectivit...