The purpose of the recent research was to assess the chemical characterization and antioxidant, cytotoxic, antibacterial, and antifungal effects of Allium Saralicum R.M. Fritsch leaves. After identification of the plant, its ethanolic extract was obtained using Soxhlet extractor without leaving ...

Tryptamines 1, 2 and 3 have been synthesised in a convergent and efficient manner by reaction of a novel methiodide 4c with the anions of the cyclic sulphamides 5, 6 and 7 as the key step.

The chemical reaction of 2-chloroethanol with 1-vinylimidazol as precursor led to the corresponding compound 1-hydroxyethyl-3-vinylimidazolium chloride [EtOHVIM+] [Cl−]. In the next step, treatment of [EtOHVIM+][Cl−] with 2,2-azobisisobutyronitril (AIBN) afforded the poly1-(hydroxyethyl)-3-vinyl...

Glibenclamide is a potent inhibitor of the ATP-dependent potassium channel. Opening of the ATP-dependent potassium channel is regarded as a mechanism of ischemic preconditioning. This in vitro study examines the influence of glibenclamide and glimepiride, a new sulfonylurea, on the negative inot...

1.1. The effects of rilmakalim, a potassium channel opener, were studied on rabbit cardiac Purkinje, ventricular muscle and atrial fibers, with the use of conventional microelectrode techniques.2.2. Rilmakalim (0.24-7.2 μM) shortened, in a concentration-dependent manner, the action potential du...

The synthesis of westiellamide analogues, wherein the oxazoline units are replaced by oxazole or thiazole units, is presented. The structures of these analogues, and also of an imidazole-based analogue, were investigated using X-ray diffraction and DFT-based molecular modelling calculations. We ...

The crystal structures of three salts of hexane-1,6-diamine: acetate (C6H18N22+·2(C2H3O2)-), dichloroacetate (C6H18N22+·2(C2HCl2O2)-) and trichloroacetate (C6H18N22+·2(C2Cl3O2)-) have been determined by X-ray diffraction at 100(1) K. In all three cases the cations are symmetrical, and occupy ...

Linear and branched compounds that contain two, three or five units of galloyl (3,4,5-trihydroxybenzoyl) or its isomer 2,3,4-trihydroxybenzoyl, as well as other mono- or dihydroxybenzoyl moieties have been synthesized. These molecules have been evaluated for their in vitro inhibitory effects aga...

Reactive absorption of carbon dioxide with solutions of 1,6-hexamethylenediamine (HMDA) in methanol and water was studied in stirred cell and model stirred contactor at 303 ± 1 K. The volumetric rate of absorption of pure CO2, at atmospheric pressure, was measured using a soap-film meter of app...

Judicious design alkyl side chain decorated fused aromatic heterocycles as π-spacers has proved to be an efficient strategy to construct highly efficient organic sensitizers. Three novel metal-free dyes W02–04 featuring a highly planar and extensively conjugated 9H-thieno[2′,3':4,5]thien...

A method for determining a selective muscarinic agent, LY297802 (compound I), [(3-(3-1-butylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane], indicated in the treatment of pain, in rat, rabbit, and monkey plasma is described. The analytes, including an internal standard, were extracted fr...

In this study, we report on the syntheses of novel donor–acceptor molecules. These new dyes comprised benzo[c][1,2,5]thiadiazole and pendants with one or two 4-alkoxythiazoles as donor parts, which were introduced without Pd-catalyzed cross coupling reactions. The optical and electrochemical pr...

A series of novel di(1-benzothieno)[3,2-b:2′,3′-d]pyrrole (DBTP)-based organic dyes (WL5-10) with D-D-π-A or D-D-A-π-A configurations are designed and the relationship between the properties and molecular configurations of these organic dyes are studied systematically. WL5,7–8 with D-D-π-A...

Lycopodium alkaloids, (±)-fawcettimine (1) and (±)-8-deoxyserratinine (3) were stereoselectively synthesized through the stereoselective Diels-Alder reaction and the regioselective aldol condensation reaction of the dialdehyde (8).

The concept of carbocycle-heterocycle equivalency has been utilised to assemble the framework of fawcettimine-serratinine group of alkaloids from 1,5-cyclooctadiene through a common tricarbocyclic intermediate 3.

Ten new fawcettimine-related alkaloids, i.e., lycopoclavamines, lycoposquarrosamine-A, and other hydroxylated fawcettimine derivatives, were isolated from three species of Lycopodium (Lycopodium clavatum, Lycopodium serratum, and Lycopodium squarrosum). The structures of the new alkaloids were e...

Five new trace alkaloids with fawcettimine-related structures (1–5), i.e., 6-hydroxyl-6,7-dehydrolycoflexine (1), 6-hydroxyl-6,7-dehydro-8-deoxy-13-dehydroserratinine (2), together with three known ones (6–8), were isolated from the club moss Lycopodium japonicum Thunb. Their structures were e...

Five new fawcettimine-type alkaloids (1–5) and three new natural products (6–8), along with four known analogues, fawcettimine (9), fewcettidine (10), lycopoclavamine B (11), and lycopladine B (12), were isolated from the whole plant of Lycopodium complanatum var. glaucum Ching. The structures...

An unprecedented C-4/C-7 linkage fawcettimine-related Lycopodium alkaloid, lycoclavatumide (1), and a new lycopodine-type alkaloid, 8β,11α-dihydroxylycopodine (2), were isolated during the phytochemical investigation of Lycopodium clavatum collected from Thailand. The structures of the alkaloi...

Enantioselective divergent total syntheses of (+)-fawcettimine, (+)-fawcettidine, (+)-lycoflexine, (+)-lycoposerramine Q, (−)-Huperzine Q and (+)-N-oxyhuperzine Q have been described from a common precursor. The syntheses feature a vinylogous Rubottom oxidation and several biomimetic transformat...