Key compound 2-(4-amino-5-oxo-3-(thiophene-2-ylmethyl)-4,5-dihydro-1,2,4-tiazole-1-yl) acetohydrazide (3) was synthesized by reacting hydrazine hydrate with ethyl-2-(4-amino-5-oxo-3-(thiophene-2-ylmethyl)-4,5-dihydro-1,2,4-tiazole-1yl)acetate (2), obtained in basic media from 4-amino-5-(thiophen...

The reaction of 2,5-dihydroxyacetophenone I or 1-(1,4-dihydroxynaphthalen-2-yl)ethanone II with various 4-aryl thiosemicarbazides did not yield the expected 4-aryl-1-[1-(2,5-dihydroxyphenyl)ethylidene]thiosemicarbazides III nor 4-aryl-1-[1-(1,4-dihydroxy-naphthalen-2-yl)ethylidene]thiosemicarbaz...

Herein, a direct and easy method for preparing 2-oxo-, 2-thione- or 2-imine-1,3-heterazolidines derived from ephedrines and norephedrines are reported. The method is based on solvent free heating of ephedrines with oxocyanate or thiocyanate salts (180–200 °C). In the reactions with potassium o...

The synthesis, crystal structures, physicochemical properties and complex formation constants of [Cu(phen)2(L)](ClO4)2 complexes, where phen is 1,10-ortho-phenanthroline and L is a series of substituted imidazolidine-2-thione, have been studied. Single crystal X-ray diffraction revealed a distor...

Stereoselective [3+2] cycloadditions of trimethylenemethane (TMM) to the exocyclic CO and CN double bonds of (1S,3EZ,4R)-3-arylimino-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones gave the corresponding spiro[bicyclo[2.2.1]heptane-2,2′-furan] and spiro[bicyclo[2.2.1]heptane-3,2′-pyrrolidine] deriv...

Supercooled smectic cholesteryl myristate nanoparticle dispersions, a potential carrier system for lipophilic drugs, can be stabilized with phospholipids and their mixtures with sodium glycocholate. Such dispersions are commonly prepared by high-pressure melt homogenization. As cholesterol ester...

Supercooled smectic cholesterol ester nanoparticles are under investigation as a new carrier system for lipophilic drugs. The smectic thermotropic liquid crystalline state of the matrix lipid is expected to lead to advantages with respect to physicochemical stability and drug loading capacity. S...

Biodiesel is a mixture of esters of fatty acids (most often palmitic, stearic and oleic) and lower alcohols (in our work butanol) produced by transesterification. It is a renewable source of energy, prepared from triacylglycerides, which are contained in vegetable oils and animal fats. This work...

Isopropyl myristate is a useful functional molecule responding to the requirements of numerous fields of application in cosmetic, pharmaceutical and food industry. In the present work, lipase-catalyzed production of isopropyl myristate by esterification of myristic acid with isopropyl alcohol (m...

Here, we investigate the coexistence of surfactant micelles and acid-soap crystallites in solutions of potassium myristate (n-tetradecanoate) to determine the micelle composition and charge, and the stoichiometry of the acid soaps. We carried out parallel pH, conductivity, and solubilization mea...

Phenacetin, N-methylacetanilide and N-ethylacetanilide prevented N-2-fluorenylacetamide hepatocarcinogenesis in F344 strain rats. Phenacetin was most effective followed by N-ethylacetanilide. Phenacetin was not carcinogenic when fed at 0.8% level for 16 weeks followed by control diet for another...

The toxicokinetics and subcellular covalent binding of the avicide 2-chloro-4-acetotoluidide (CAT) were examined in the starling. Intravenous administration of 4.5 mg/kg ringlabeled [14C]-CAT produced biphasic decay curves of the radioactivity in plasma and other tissues. The alpha phase of the ...

As previously shown a 44- to 65-fold molar excess of acetanilide protected rats againts liver tumor induction by N-2-fluorenylacetamide. Analogs of acetanilide, the o-, m-, and p-isomers of acetotoluidides and aminobenzoic acids, were tested for inhibitory potential at a 44-fold molar excess dos...

Present experimental approaches dealing with the mechanisms of carcinogenesis attempt to relate the known combinations of carcinogen with cellular macromolecules and the specific interaction necessary for the carcinogenic process. With this aim the effect of prefeeding a series of inhibitors of ...

The corrosion behaviors of hafnium in Et4NBr isopropanol and acetonitrile(ACN) solutions were investigated using electrochemical measurements, ICP-AES and SEM techniques. Results revealed that the open circuit potential gets more positive due to the increased passivity of the surface oxide film ...

We report a unique aqueous solution deposition method to prepare yttrium doped hafnium oxide (Y:HfO2) thin films using all-inorganic reagents. The composition and chemical bonding features of the films were investigated using X-ray photoelectron spectroscopy. The Y:HfO2 film was integrated into ...

Hafnium ethoxide was synthesized using electrochemical method. Optimization experiments were used to optimize various parameters namely Et4NBr concentration(c): 0.01–0.06 mol/L, solution temperature (t): 30–78 °C, polar distance (D): 2.0–4.0 cm and current density (J): 100–400 A/m2. The ele...

The reaction of pyridine-2-carbonitrile (2-CNpy) with 2-amino-2-hydroxymethyl-1,3-propanediol (AL1) , 2-amino-2-methyl-1,3-propanediol (AL2) and 2-amino-2-methyl-1-propanol (AL3) in ethanolic solutions of Cu (II) and Co (II) salts led to the formation of solid complexes containing 2- (2-pyridiny...

Copper(II), iron(II), and manganese(II) complexes of 2-methyl-2-(2-pyridinyl)-1,3-propanediamine (ppda) were synthesized and characterized. The reaction of copper(II), iron(II), or manganese(II) salts with ppda yields complexes [Cu(ppda)Cl2] (1), [Cu(ppda)2](OTf)2 (2), [Fe(ppda)2](OTf)2 (3), and...

Terephthalic acid (TPA), dimethyl terephthalate (DMT), and melamine (MA) induced calculi and transitional cell hyperplasia in urinary bladders of rats. A high incidence of calculi was induced in weanling rats, but the incidence was much lower in adult rats ingesting the same dietary concentratio...