In this study, red seaweed (Gracilaria lemaneiformis) food waste with high carbohydrate content was valorized into levulinic acid (LA) and algae hydrochar through microwave-assisted low-temperature hydrothermal treatment in dilute acid solution. Various parameters including treatment temperature...

ABSTRACTThis study aimed to evaluate the effect of replacing maize silage plus soybean meal with red clover silage (RCS) plus wheat on the fatty acid (FA) profile in the milk fat of cows. Forty-four lactating German Holstein cows were used in a 4 × 4 Latin square design with 21-d periods compos...

Imbalanced dietary levels of branched-chain amino acids (BCAAs) are known to produce antagonistic effects in pigs, rats and humans, affecting the concentration of BCAAs in plasma and ultimately depressing growth. In fish, antagonism involving BCAAs has not been fully characterized or understood....

ObjectiveTo investigate whether red ginseng extract can affect the pharmacokinetics of aspirin in Sprague Dawley (SD) rats.

The addition of 1-butylpyrrolidine to AlCl3 results in the formation of an electrolyte that is suited to Al deposition. The feasibility of electrodepositing Al from the synthesized electrolyte was investigated. Several compositions of AlCl3 and 1-butylpyrrolidine were prepared for this purpose. ...

The crystal structures of three isomeric methoxy substituted bis-chloro bridged (N, N-dimethylbenzylamine)palladium(II) dimers have been determined by X-ray diffraction. Both the ortho-isomer (1) and the meta-isomer (2) are monoclinic, spacegroup P21/c with Z = 2 in cells of dimensions a 5.7391(...

The course of transformations of five 4-ene-3-oxo steroids with varying substituents at C-17 i.e.: 4-androsten-3-one, androstenedione, testosterone, progesterone and 17α-hydroxyprogesterone in Fusarium culmorum culture was investigated. All the substrates were hydroxylated either at 12β and 15...

BackgroundCurrently, the synthetic steroid ethinylestradiol (EE) is the preferred estrogen in combined oral contraceptives. The aim of the present study was to evaluate the effectiveness of the natural steroid estetrol (E4) as an ovulation inhibitor in rats when compared to EE.

Quantitative bioanalysis and especially pharmacokinetic studies are challenging since only low volumes of biological material are available and low concentrations (ng/ml) are often expected. In this context, volumetric absorptive microsampling (VAMS) devices were developed to accurately collect ...

SummaryObjectiveThe effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone (DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG), angiotensinogen and 12 hemostasis markers.

IntroductionEstetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in...

IntroductionEstetrol (E4), a naturally occurring estrogen only produced by the human fetal liver, is being evaluated in human studies for potential use in contraception and menopausal care. The present study was designed to profile E4 in the central nervous system, to assess the in vivo effects ...

Neonatal Hypoxic-Ischemic Encephalopathy (HIE), a brain disease due to brain hypoxia along with ischemia and reduced cerebral blood flow, is one of the primary reasons of severe injury among babies prematurely born. No efficacy treatment is available to the present day. Estetrol (E4), a major es...

In this paper the potential clinical applications for the human fetal estrogen estetrol (E4) are presented based on recently obtained data in preclinical and clinical studies. In the past E4 has been classified as a weak estrogen due to its rather low estrogen receptor affinity. However, recent ...

Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advant...

ObjectiveEstetrol (E4) is a natural fetal estrogen. The safety of increasing doses of E4 and its preliminary effects on the vagina, endometrium and menopausal vasomotor symptoms were investigated.

BackgroundEstetrol (E4) is a natural estrogen produced solely during human pregnancy. E4 is suitable for clinical use since it acts as a selective estrogen receptor modulator. In clinical trials E4 has been seen to have little or no effect on coagulation. Hence, it is interesting to investigate ...

In the present work, artificial neuron network (ANN) based models for predicting equilibrium solubility and mass transfer coefficient of CO2 absorption into aqueous solutions of high performance alternative 4-diethylamino-2-butanol (DEAB) solvent were successfully developed. The ANN models show ...

A multi-layer perceptron neural network (MLPNN) model with Levenberg–Marquardt learning algorithm were applied to model CO2 capture by a novel amine solution called 4-diethylamino-2-butanol (DEAB). The MLPNN model predicted the CO2 concentration and temperature profiles along the height of the ...

Grafting the molecular complex (MesN)2Mo(CH2CMe2Ph)2 onto the surface of silica dramatically enhances its catalytic activity in the oxo/imido heterometathesis reaction of N-sulfinylamines with carbonyl compounds.