Recent studies show that electrochemical biosensors offer simple, robust and low-cost solution for point-of-care applications. To meet rigorous requirements of early disease diagnosis and other medical applications, nanomaterials have been investigated to increase sensitivity and selectivity of ...

The main purpose of this work is to provide insight into the molecular frameworks that are the products of 3‑aminobenzoic acid (3ABA) polymerization. The employment of vibrational spectroscopic (FTIR and FT-Raman) and mass spectrometric (MS) methods enabled us to determine the structures of olig...

An efficient and novel enantioseparation and determination method was developed to quantify the enantiomers of chiral triazole fungicide triticonazole in fruit, vegetable, and soil samples. Under the optimal chromatographic conditions, the enantiomers of triticonazole were completely enantiosepa...

A highly fast analytical method though supercritical fluid chromatography (SFC) has been developed to quantify triticonazole enantiomers in cucumbers and tomatoes. Effects of organic modifier type and concentration on chiral separation and quantification of standard solution as well as matrix-ma...

Triticonazole with an asymmetrical carbon atom has two enantiomers and is a broad-spectrum systemic fungicide, but its disposition in animals is unclear. In this study, a chiral analytical method of LC–MS/MS was developed and validated for the assay of triticonazole enantiomers in rat plasma an...

This paper describes the design and synthesis of a new class of molecules, the 3-sulfonylamino-2-(1 H)-quinolones, which are potent and selective antagonists at both the AMPA/kainate site as well as at the NMDA-associated glycine site. The molecules were characterized by their binding affinities...

Our research objective was to optimize and design nano-biosystem of Isradipine (IDP) via novel bioenhancer (Rutin) loaded solid-lipid nanobioparticles (ANbp) using Taguchi design (TgD) methodology. Firstly, preliminary screening of solid lipid nanoparticles (SLNps) formulation core factors (A, B...

The combination of a membrane bioreactor using lipase from Serratia marcescens and a crystallizer has been proposed for the production of optically active (2R, 3S)-3-(4-methoxyphenyl) glycidic acid methyl ester ((−)MPGM) from racemic compounds ((±)MPGM). The reaction kinetics were investigated ...

Addition reactions of the chiral lithium (2S)-enolates of the (2S,5S)-2-tert-butyl-5-methyl-[1,3]dioxolan-4-one and (2S,5S)-2-tert-butyl-2,5-dimethyl-[1,3]dioxolan-4-one with linear aliphatic acylsilanes yield the corresponding (2S,5R,1′R)-1′-trimethylsilyl-dioxolanone alcohols. Sodium methoxi...

SummaryThe lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity of targets for therapeutic intervention. Here we used an integrated discovery paradigm to identify a new therapeutic target for dis...

(+)- and (−)-Neopyrrolomycins have been synthesized from 3,5-dichlorophenol through regioselective halogenations and optical resolution.

Herein, a newly designed and synthesized fiber-supported [email protected](I) served as efficient and recyclable polymer-supported copper complex catalysts for alkyne coupling and cycloaddition reactions, is reported. The fiber-supported copper complex catalyst was prepared systematically from c...

Two [18F]-labelled analogues of the potent muscarinic cholinergic receptor (m-AChR) antagonist, dexetimide, were evaluated as potential ligands for imaging m-AChR by positron emission tomography (PET). Intravenous administration of both 2-[18F]- or 4-[18F]- fluorodexetimide resulted in high brai...

Two 18F-labeled analogues of dexetimides, 2-[18F]fluorodexetimide (2-FDEX) and 4-[18F]fluorodexetimide (4-FDEX), were prepared and evaluated in vivo as possible agents for the study of the muscarinic acetylcholine receptor (mAChR) with PET. Two synthetic approaches, a 2-step reductive alkylation...

3,5-Dibromoisothiazole-4-carbonitrile 1 treated with Zn or In dust (5 equiv) and HCO2H undergoes regioselective hydrodebromination to give 3-bromoisothiazole-4-carbonitrile 3 in 70–74% yield. Similarly, 5-bromo and iodo 3-chloroisothiazole-4-carbonitriles 8 and 9 give 3-chloroisothiazole-4-carb...

New pyrazolo[3,4-d]pyrimidinone and pyrazolo[4,3-e][1,2,4]triazolo[4,3-a]pyrimidinone derivatives were synthesized. They have been evaluated for their anti-inflammatory activity using in vitro (COX-1/COX-2) inhibitory assay. Moreover, compounds with promising in vitro activity and COX-1/COX-2 se...

The entitled ligand and its metal complexes derived from chloride salts of Mn(II), Co(II), Ni(II), and Cu(II), and Cd(NO3)2 were prepared. The structures were confirmed by analytical, different spectral techniques and thermogravimetric analysis. Complexes are formed with stoichiometries 1:1 and ...

The use of recycled process water in steam crackers leads to the accumulation of corrosive impurities, hence the need for adequate treatment. Two corrosion inhibitor formulations containing N-[(9Z)−9-octadecen-1-yl]−1,3-propanediamine (N-oleyl-1,3-propanediamine) with either cyclohexanamine (CHA...

The densities and viscosities of binary mixtures monoethanolamine (MEA) + H2O, 2-(Diethylamino)ethanol (DEEA) + H2O, MEA + DEEA and ternary mixtures MEA + DEEA + H2O were measured over the entire composition at temperatures ranging from (293.15 to 333.15) K and atmospheric pressure. The volumetr...

The fatigue strength of polycrystalline cp-Ti depends on a variety of different factors especially its plastic deformation mechanism. Deformation twinning is activated as a major deformation mechanism in cp-Ti during cyclic deformation. The fatigue-induced twin transformation developing on the s...