The late Paleozoic and early Mesozoic Indosinian Orogeny in Southeast Asia was characterized by subduction in the Paleo-Tethys and collisions among continental blocks and fragments. The Khorat Plateau Basin in northeastern Thailand covers much of the Indochina Block and was subjected to complex ...

Crustal thickness (H) and Vp/Vs (κ) measurements obtained by stacking P-to-S receiver functions recorded at 32 broadband seismic stations covering the Indochina Peninsula reveal systematic spatial variations in crustal properties. Mafic bulk crustal composition as indicated by high κ (>1.81) o...

We analyzed teleseismic receiver functions of 9 sites to determine the crustal structure beneath the Indo-Burmese subduction region (IBR), which is seismically one of the most active subduction zones of the Indian subcontinent. The receiver function analysis of the primary and reverberated phase...

In the symbolic number comparison task, the size effect (better performance for small than for large numbers) is usually interpreted as the result of the more general ratio effect, in line with Weber's law. In alternative models, the size effect might be a result of stimulus frequency: smal...

A new type of cationic-modified silica gel (CM-SG) adsorbent was prepared and its structure and properties were characterized by FI-IR, elemental analysis, XRD, BET, SEM–EDX, particle size and Zeta potential analysis. The results showed that the cationic polymer EPI–DMA had been successfully g...

Effective thermal conductivity of a silica-gel/water adsorption packed bed is significantly enhanced by placing silica-gel particles in a high-porosity aluminum foam. The enhancement leads to several folds increase in the specific cooling power (SCP), cooling capacity per unit volume (CPv) and c...

Goniodomin A causes the conformational change of actin to modify actomyosin ATPase activity [Furukawa, K.-I., Sakai, K., Watanabe, S., Maruyama, K., Murakami, M., Yamaguchi, K., Ohizumi, Y., 1993. Goniodomin A induces modulation of actomyosin ATPase activity mediated through conformational chang...

The dinoflagellate Alexandrium pseudogonyaulax is widely distributed around the world including the Mediterranean waters. The objectives of this study were to determine the morphology and phylogenic affiliation of A. pseudogonyaulax strain isolated from Bizerte Lagoon (Mediterranean waters, Tuni...

An external standard of goniodomin A (GDA) was prepared from a strain of Alexandrium pseudogonyaulax originating from New Zealand and its chemical structure was confirmed by nuclear magnetic resonance (NMR) spectroscopy. Using the GDA standard, an ultra-performance liquid chromatography-tandem m...

Goniodomin A is a phycotoxin produced by the dinoflagellates Alexandrium hiranoi (formerly Goniodoma pseudogoniaulax) and Alexandrium monilatum. This polyether macrolide exerts a potent antifungal effect and disturbs the actomyosin ATPase activity and the F-actin meshwork in diverse cell types. ...

The death rate from cancer and infectious diseases is still very high, therefore research in this area is extremely important and promising as in medical, so in economic point of view. Thus, potassium salt of tetrazolo[1,5-c]quinazolin-5-thion was modified per alkylation by N-aryl(benzyl,heteryl...

Antidepressant drugs, such as the tricyclics and the serotonin reuptake inhibitors, are well known to decrease paradoxical sleep and occasionally increase slow wave sleep in human and in animals. In order to examine whether amoxapine (a mixed NA reuptake blocker and 5-HT2/5-HT3 antagonist) and c...

The aminoacyl-tRNA synthetase (aaRS) class of enzymes is a validated target for antimicrobial development. Aminoacyl analogues of 5′-O-(N-l-aminoacyl)-sulfamoyladenosines are known to be potent inhibitors of aaRS, but whole cell antibacterial activity of these compounds is very limited, and poo...

The superfamily of adenylate-forming enzymes all share a common chemistry. They activate a carboxylate group, on a specific substrate, by catalyzing the formation of a high energy mixed phosphoanhydride-linked nucleoside intermediate. Members of this diverse enzymatic family play key roles in a ...

Aminoacyl-sulfamoyl adenosines are well-known nanomolar inhibitors of the corresponding prokaryotic and eukaryotic tRNA synthetases in vitro. Inspired by the aryl-tetrazole containing compounds of Cubist Pharmaceuticals and the modified base as found in the natural antibiotic albomycin, the sele...

In order to increase the success rate for developing new Cdc7 inhibitors for cancer therapy, we explored a new chemotype which can comply with the previously-constructed pharmacophore model. Substitution of a pyridine ring of a serendipitously-identified Cdc7 inhibitor 2b with a 3-methylpyrazole...

The effects of two 5-HT1A receptor antagonists, (R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate (NAD-299) and N-(2-(1-(2-methoxyphenyl)-piperazinyl))ethyl)-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY-100635) on...

SummaryThe cycloaddition reactions have been explored extensively and provided an efficient strategy for the synthesis of cyclic compounds. Traditionally, the reaction partners were in extenso incorporated into the cyclic products without fragmentation. From a different perspective, if certain f...

Bis(β-carbomethoxyethyl)tin dichloride forms coordination complexes of formula R2SnCl2L2, R2SnL′2 and R2SnCl(oxin) where L2 = 2Ph3AsO, phen, bipy and L′ = oxin, . However, it exhibits weaker acceptor properties towards other ligands including phosphine oxides. Structural features of the isola...

On irradiation of 4-phenoxybut-1-enes substituted with a carbomethoxy group in the arene, only the ortho compound 1 led to notable ortho photocycloaddition, while the meta regioisomer 2 furnished meta and ortho photocycloadducts albeit in low yield, and the para-substituted compound 3 resulted o...