The crystal structure of IPh2SnCH2CH2Co2Me: C16H17IO2Sn (10; X = I) has been determined; the tin atom adopts a distorted trigonal bipyramidal geometry, with iodine and the internal carbonyl oxygen in axial sites. The chelated structure of 10 (X = I) [v(CO) 1684 cm−1] persists in such solvents as...

A porcine pancreatic lipase mediated enzymatic hydrolysis of (±)-1-acetoxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane (5b) furnished (1S,7aS)-1-acetoxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane (9) and (1R,7aR)-1-hydroxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyl...

Bis(2-carbomethoxyethyl)chloro(quinolin-8-olato)tin(IV), C17H20ClNO5Sn, crystallizes in the triclinic space group P1, with a 7.9001(7), b 10.2636(7), c 12.8287(9) Å; α 108.575(7), β 98.564(6), γ 96.469(7)°; V 960.69 Å3, Z = 2. The coordination geometry around the tin atom approximates to a s...

The crystal structure of bis(2-carbomethoxyethyl)bis(N,N-dimethyldithiocarbamato)tin(IV) was determined from 2495 observed Mo-Kα reflections and refined to an R factor of 0.053 (space group P21/c; a 15.629(4), b 10.574(3), c 16.118(4) Å; β 117.00(2)°; V 2373(1) Å3; Z = 4). The compound is mon...

The binding of alkylendiamide dimers of the three N-terminal residues of [D-Ala2, D-Leu5]enkephalin (DADL) to rat brain and Ng108-15 neuroblastoma-glioma cell membranes was compared with that of DADL, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO) and morphiceptin. Tritiated DADL and DAGO were used as labe...

Recently, it has been demonstrated that fibroin and fibroin-derived peptides enhances insulin sensitivity and glucose metabolism in adipocytes. Here, we show that a synthetic hexapeptide Gly-Ala-Gly-Val-Gly-Tyr (GAGVGY) derived from repetitive amino acid sequence of fibroin improves glucose tran...

Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2), and MIF-1 (Pro-Leu-Gly-NH2) are biologically active peptides previously isolated from brain tissue. We now have used size exclusion chromatography and several consecutive rp-HPLC steps monitored by RIA to isolate a structurally ...

Lys-His-Gly-NH2 has been claimed to selectively induce B cell precursors to differentiate into mature B lymphocytes. In the present study, the effects of this tripeptide and a control compound having the reverse sequence (Gly-His-Lys-NH2) on growth and differentiation of chicken and mouse B cell...

Using a radioimmunoassay for the sequence Arg-Phe-NH2 (RFamide), we have isolated the peptide

The synthesis, in vitro evaluation and conformational study of His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and analogues acting as antifungal agents are reported. Among them, His-Phe-Lys-Trp-Gly-Arg-Phe-Val-NH2 exhibited a moderate but significant antifungal activity against Cryptococcus neoformans, Can...

Opioid peptides and alkaloid drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor which belongs to the G protein-coupled receptor (GPCR) family. A new important pharmacological concept in the field of GPCRs ...

ObjectiveTo characterize the interactions between the cholinergic and prostaglandin signaling systems within the urothelium-lamina propria of the guinea pig and elucidate the role of muscarinic receptors in these interactions.

Triple-negative breast cancer (TNBC) is a subset of breast cancers which is negative for expression of estrogen and progesterone receptors and human epidermal growth factor receptor-2 (HER2). Chemotherapy is currently the only form of treatment for women with TNBC. Growth hormone-releasing hormo...

The aim of this study was to evaluate the caffeic acid antioxidant and cytoprotective activity against Mercury Chloride (HgCl2) action. DPPH and iron chelation assays were performed to evaluate the antioxidant activity. The interaction between the metal and phenolic compounds was identified by F...

ObjectivesWe have assessed the effect of elevated concentrations of hydroxyphenylpyruvic acid (HPPA), hydroxyphenyllactic acid (HPLA) and tyrosine, on a range of chemistry tests in serum and urine to explore the potential for chemical interference on routine laboratory analyses in patients with ...

Oats contain a range of phenolic acids and avenanthramides which may have healthbenefits. Analysis of 22 commercial oat products (oat bran concentrate, oat bran, flaked oats, rolled oats and oatcakes) using HPLC-DAD detected eleven bound and thirteen free + conjugated phenolic acids and avenanth...

The aim of this research was to study the potential of malolactic fermentation to modify the composition of the juices of sea buckthorn, chokeberry and lingonberry. Juices were prepared with and without pectinolytic enzyme treatment, followed by fermentation with commercially available strains o...

The inhibition of human pancreatic α-amylase (HPA) enzyme activity can offer facile routes to ameliorate postprandial hyperglycemia in diabetes via control of starch digestion. The present study utilizes complementary experimental (starch digestion kinetics, fluorescence quenching, Förster reso...

High-performance liquid chromatography (HPLC) was employed for the separation and determination of becliconazole, an imidazole derivative with antifungal activity containing a stereogenic centre, and its impurities. Chiral columns, containing carbamate of cellulose and amylose, were used. The ef...

Surface-functionalized polymeric nanoparticles were prepared by: a) self-assembly of poly(4-vinylbenzocyclobutene-b-butadiene) diblock copolymer (PVBCB-b-PB) to form spherical micelles (diameter: 15–48 nm) in decane, a selective solvent for PB, b) crosslinking of the PVBCB core through thermal ...