A putative pineal metabolite, 5-methoxyindole-3-acetic acid, was quantified in human urine by a gas chromatographic-mass spectrometric method. Excretion of 4.77 ± 2.25 μg/day (mean ± SD) was consistent from each of three normal subjects over 2–4 weeks. Excretion did not vary with regard to m...

6-Methoxy-2-benzoxazolinone (6-MBOA), a naturally occurring progonadal compound present in grasses with structural resemblance to melatonin, was tested for antifungal activity against Fusarium oxysporum, Rhizoctonia solani and Coprinus comatus. A variety of pineal products was also examined for ...

The thiazolidinediones (TZDs) are a class of oral antidiabetic drugs that improve insulin sensitivity in patients with type 2 diabetes. Although the mechanism by which the TZDs lower insulin resistance is unclear, they are known to target the peroxisome proliferator-activated receptor γ (PPARγ...

2-(4-Nitrophenyl)-1H-benzo[d]imidazole (4-NBI) was prepared and characterized by experimental and computational methods. Electrochemical reduction of the compound was studied in dimethyl sulphoxide media which showed that the nitro group of the molecule undergoes quasireversible three-step reduc...

Single crystals of organic-inorganic hybrid compound Bis(1-(4-Nitrophenyl)-1H-imidazolium) tetrachlorocobaltate monohydrate, was obtained by slow evaporation of an aqueous solution at room temperature and characterized by a single-crystal X-ray diffraction, an elemental and thermal analysis, UV–...

In search of potent inhibitors of cholinesterases, we have synthesized and evaluate a number of 2,3-dihydroquinazolin-4(1H)-one derivatives. The synthetic approach provided an efficient synthesis of the target molecules with excellent yield. All the tested compounds showed activity against both ...

A benign, simple, and efficient synthesis of 4-alkyl-5-methyl-1H-pyrazol-3-ols has been described in refluxing water through the four-component reaction of β-ketoesters, hydrazine hydrate, different aldehydes, and acetophenone derivatives in the presence of nano Al2O3@Cg, as a novel nanocatalys...

Nine novel {bis-4-[(3-alkyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-iminomethyl]-phenyl} [1,1′-biphenyl]-4,4′-disulfonates were synthesized and their structures were determined with spectral methods. Corrosion inhibitor activities of the title compounds were investigated using quantum mechanical meth...

AimThe aim of the present work was to develop a simple and reliable isocratic Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) method and to validate the method for the quantitative estimation of Ceftiofur Hydrochloride in bulk form.

The purpose of this study was to investigate the residue elimination of ceftiofur hydrochloride in milk of postpartum cows after intramammary infusing at dry-off. An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to detect ce...

Fifty members of a novel class of antimicrobial compounds, 2-(4-R-phenoxymethyl)benzoic acid thioureides, were synthesized and characterized with respect to their activities against three parasites of human relevance, namely the protozoa Giardia lamblia and Toxoplasma gondii, and the larval (met...

Two series of 1,2,4-triazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potential. All the tested compounds exhibited ant...

New enantiopure amines (R,R)-1 and (S,S)-1 were obtained from (R)- or (S)-2,2′-diamino-1,1′-binaphthyl and 2,6-diformylpyridine in a synthesis templated by lead(II) or lanthanide(III) ions, reduction with NaBH4 and subsequent demetallation. Similarly new amines (R,R,R,R)-2 and (S,S,S,S)-2 were...

Inhibitors of the metabolism of the endogenous cannabinoid ligand anandamide by fatty acid amide hydrolase (FAAH) reduce the gastric damage produced by non-steroidal anti-inflammatory agents and synergise with them in experimental pain models. This motivates the design of compounds with joint FA...

The synthesis and characterization of two new cobalt(II) coordination compounds with nicotinamide (nia) and isonicotinamide (isn) are reported. The products were characterized magnetically, structurally by single-crystal X-ray diffraction analysis and spectrally by FT-IR spectroscopy. Using the ...

Esculentic acid (EA), a pentacyclic triterpenoids compound extracted from the Chinese herb Phytolacca esculenta, has long been used in traditional Chinese medicine for the treatment of rheumatoid arthritis, edema, hepatitis and bronchitis disease. The present study aimed to investigate the anti-...

Esculentic acid (EA), a triterpene compound extracted from the root of Phytolacca esculenta (the Chinese name Shang Lu), has been widely used to therapy a variety of inflammatory diseases such as rheumatoid arthritis, edema, hepatitis and bronchitis. The present study was designed to investigate...

A sensitive method for determination of the N-methylcarbamoyl adduct at the N-terminal valine of globin, a new metabolic product of the industrial solvent N,N-dimethylformamide (DMF), has been developed and validated. The method includes conversion of the adduct by the Edman degradation to 3-met...

N-Hydroxymethyl-N-methylformamide (HMMF) and N-methylformamide (NMF) in urine samples from workers exposed to N,N-dimethylformamide (DMF) cannot be distinguished by a gas chromatographic method because HMMF is converted to NMF at the injection port of gas chromatography (GC). Total NMF (HMMF + N...

The reaction between 6-acetyl-3-alkyl-1-ethoxy-3,4,5a,6,11,11a-hexahydro-10bH-pyrazino-[2′,1′-5,1]pyrrolo[2,3-b]indole-1,4-diones and anthranilic acid was studied from a stereochemical point of view. Various degrees of epimerization of the tryptophan and alanine stereocenters were observed in ...