The cerous p-methoxybenzenesulfonate (I) and cerous p-toluenesulfonate (II) mediators were prepared and studied by electrochemical and kinetic methods. The reactivity of several alcohols, diols and arenes in the oxidation reaction with I and II was established, and electrochemical oxidation of s...

To expand the understanding of the chemistry of propargyl acetals, their gold(I) catalysed cycloaddition reactions with alkynes have been investigated. We hereby report a novel tandem reaction that allows the construction of a new type of polysubstituted and highly functionalised bicyclic pental...

The rates of the base-catalysed eliminations of a series of p-substituted phenyl β-chloroethyl sulfones have been determined in anhydrous acetonitrile using Et3N, Et2 NCH2CH2OH, EtN(CH2CH2OH)2 and N(CH2CH2OH)3 as the bases. The relative rates obtained with these amine bases were 550:52:6·6:1, ...

The design, synthesis, and biological evaluation of β-keto sulfones as 11β-HSD1 inhibitors and the mechanism of inhibition are described here. This class of compounds is not active against 11β-HSD2 and therefore may have therapeutic potential for metabolic syndrome and type 2 diabetes.

A number of 2-(furan-2-yl)-4-phenoxyquinoline derivatives have been synthesized and evaluated for anti-inflammatory evaluation. 4-[(2-Furan-2-yl)quinolin-4-yloxy]benzaldehyde (8), with an IC50 value of 5.0 μM against β-glucuronidase release, was more potent than its tricyclic furo[2,3-b]quinol...

This paper outlines our efforts to study the influence of an oxygen atom adjacent to the stereogenic center of β-aminoalcohol derivatives used as ligands for catalysts in the asymmetric alkylation of aldehydes. Thirty-four enantiomerically pure (S)-dihydrofuran-2-yl, (S)-tetrahydrofuran-2-yl-, ...

Several conditions of acidic anhydrous methanolysis were examined to optimize the release and minimize the degradation of unphosphorylated 2-keto-3-deoxy-d-manno-octonic acid (KDO) from bacterial lipopolysaccharides and polysaccharides. The reaction was monitored by capillary gas chromatography ...

We have adapted the purpald assay (M. S. Quesenberry and Y. C. Lee,Anal. Biochem.234, 50–55, 1996) to quantify lipopolysaccharide (LPS) content in solution in 96-well microtiter plates at room temperature. This method employs the oxidation of unsubstituted terminal vicinal glycol groups in 2-ke...

A lipopolysaccharide (LPS)-binding lectin was recovered from the serum of Limulus polyphemus by ion-exchange chromatography. Electrophoretic analysis of this lectin preparation revealed three poorly migrating bands. When whole serum was incubated with glycolipid obtained from the Rc mutant of Sa...

A procedure is described to determine 2-keto-3-deoxyoctonate (KDO) present in lipopolysaccharide (LPS) of gram-negative bacteria. The method involves the treatment of LPS with 0.2 n H2SO4 at 100°C for 30 min to release KDO, followed by its reaction with periodic acid, sodium arsenite, and thiob...

Periodate-thiobarbituric acid reaction-positive substances were found in the strong acid hydrolysates of the lipopolysaccharide (LPS) from Bacteroides gingivalis 381. They were not identical to 2-keto-3-deoxyoctonate (KDO) in high-voltage paper electrophoresis (HVPE), their electrophoretic mobil...

Phosphorylated 2-keto-deoxyoctonate (KDO) has been detected in the stronga-acid hydrolysates of lipopolysaccharides (LPS) of family Vibroonaceae including Vibrio cholerae. Structural analysis of LPS isolated from a rough mutant of non-01 V. cholerae 05 by dephosphorylation, periodate oxidation a...

1.1. Endotoxins isolated from six serotype specific reference strains of the Bacteroides fragilis group were dephosphorylated by treatment with aqueous 50% hydrofluoric acid.2.2. Mild acidic hydrolysis of the dephosphorylated endotoxins released 2-keto-3-deoxyaldonic acid, the presence of which ...

Structural analysis of the 2-keto-3-deoxyoctonate region of lipopolysaccharide (LPS) isolated from Porphyromonas (Bacteroides) gingivalis was carried out. The substitution of the polysaccharide portion on the KDO was determined by gas chromatography/mass spectrometry of the product obtained by s...

Aminomalonic acid (Ama) was first detected in alkaline hydrolysates of proteins in 1984. In this work we describe our search for the origin of aminomalonic acid in alkaline hydrolysates of proteins. We have developed a technique for quantitation of aminomalonic acid based upon gas chromatography...

The standard molar enthalpies of formation of crystalline rubidium and cesium oxalates were determined by solution calorimetry. The values obtained for ΔfHmo(Rb2C2O4, cr 298.15 K) and ΔfHmo(Cs2C2O4, cr 298.15 K) were −(1325.0 ± 8.1) and −(1340 ± 1.5) kJ · mol−1, respectively.

Thermal analyses of rubidium and cesium oxalate monohydrates were carried out by means of thermogravimetry, differential thermal analysis and differential scanning calorimetry together with powder X-ray diffraction analysis. Both the oxalate monohydrates Rb2C2O4 · H2O and Cs2C2O4· H2O belong t...

The synthesis and characterization of new 2-hydroxyethyl methacrylate-co-methyl methacrylate/zinc phthalocyanine composite Poly(HEMA/MMA/ZnPc) is described for the first time in this study. The aim of this research is to present possibility of radiation synthesis of the newly zinc phthalocyanine...

Ionic liquids (IL) were used as solvents to study the RAFT polymerization of butyl methacrylate. The ILs offered a significant increase in the rate of polymerization and the RAFT agents contributed to a tailor-made polymer with controlled molar mass and narrow dispersity (Ð). The IL used in the ...

Hydrolysis of water-soluble industrially important mono- and poly(ethylene glycol) methacrylates catalyzed by sulfuric acid and organic monomeric acids (methacrylic and 2-acrylamido-2-methylpropanesulfonic acid) has been studied in aqueous solutions. Chemical stability of the methacrylates in di...