ABSTRACTA phase 1 clinical study was performed to assess the pharmacokinetics and safety of intravenous (i.v.) administration of colistin methanesulfonate (CMS) and azidothymidine (AZT) alone and in combination. Seven healthy subjects received three (every 12 h) 1-h i.v. infusions of 4, 2 and 2 ...

The allosteric pocket of the Dengue virus (DENV2) NS2B/NS3 protease, which is proximal to its catalytic triad, represents a promising drug target (Othman et al., 2008). We have explored this binding site through large-scale virtual screening and molecular dynamics simulations followed by calcula...

A study of the preparation of α,ω-dichloropolydiphenylsilanes from octaphenylcyclotetrasilane (I) and decaphenylcyclopentasilane (II) with chlorinating reagents such as 1,1,2,2-tetrachloroethane, phosphorus pentachloride and chlorine is discussed. The study has led to the preparation of compou...

Using the recently introduced concept of electron equivalent bond order, the characteristic bond orders of benzenoid hydrocarbons were studied based on experimental data. Fragmentation schemes can be used successfully to interpret the results and provide a very simple, consistent and useful vale...

SummaryOne challenge in tailoring organic semiconductors for sensing applications is that the introduction of reactive groups or binding sites usually impairs π-π interactions. To meet this challenge, this study puts forth an unusual type of π stacking that allows a variety of functional grou...

Effect of a hydrophobic peptide on folding of oxidized cytochrome c (cyt c) is studied with trityrosine. Folding of cyt c was initiated by pH jump from 2.3 (acid-unfolded) to 4.2 (folded). The Soret band of the 2-ms transient absorption spectrum during folding decreased its intensity and red-shi...

The Ag2S loaded ZnO (Ag2S–ZnO) was successfully synthesized by precipitation of zinc oxalate and Ag2S and calcination of the mixed precipitate at 400 °C for 12 h. The catalyst was characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) images, energy dispersive spectra (ED...

TiO2 nanotube arrays were prepared by anodization with titanium anode and platinum cathode by electrochemical and sonoelectrochemical technique. The rate of formation of the TiO2 nanotubes by the sonoelectrochemical method is found to be almost twice as fast as the electrochemical method. The ph...

Bloodstains are often encountered at scenes of violent crime and have significant forensic value for criminal investigations.Blood is one of the most commonly encountered types of biological evidence and is the most commonly observed fingerprint contaminant. Presumptive tests are used to test bl...

The present study assesses, for the first time, the use of the non-lignin residue from Kraft black liquor as a renewable source of carboxylic acids. For this purpose, the liquid fraction obtained after separating the lignin from the black liquor by acid precipitation was subjected to different h...

Azo dyes are a large group of dye compounds and their removal and treatment is very important because of their high stability and high carcinogenicity. The purpose of this study was to determine the photocatalytic efficiency of titanium dioxide nanoparticles doped with iron, chromium and nitroge...

Aluminum based metal-organic framework using a di-carboxylate linker succinic acid (Al-SA MOF), are synthesized in water with minimal generation of secondary pollutants. The physicochemical properties of Al-SA MOF were examined, followed by its utility for the adsorption of Acid Black 1 (AB1) in...

The irradiation of hexaphenylditin yields “hot” triphenyltin radicals whose decomposition into diphenyltin and phenyl radicals competes with recombination and disproportionation.

The chemical route for synthesizing eugenol benzoate is concomitant with a myriad of environmentally unfavorable practices viz. the use toxic chemicals, tedious separation process and emancipation of harmful unwanted by-products. In this perspective, an alternative technique utilizing Rhizomucor...

To overcome drawbacks in the conventional chemical route to synthesize eugenyl benzoate, immobilized Rhizomucor miehei lipase (RML) as the biocatalyst was proposed. The RML conjugated to a hybrid support consisting of biopolymers, chitosan (CS) and chitin nanowhiskers (CNWs). 1-ethyl-3-[3-dimeth...

We report lithium benzoate (LB) as an effective electron dopant for commonly used diketopyrrolopyrrole (DDP) based electron donor-acceptor conjugated polymers and its application in organic thin-film transistors (OTFTs). Three DPP derivative classes were considered: ambipolar, electron dominant,...

To overcome the solubility and bioavailability challenges of nomilin, we have formulated and characterized a nanoparticle-based delivery system. Nomilin nanoparticles were prepared with poly (lactic-co-glycolic acid) (PLGA) resomers of different co-polymer composition and molecular weights with ...

BackgroundAnimal experiment studies have revealed a positive association between intake of citrus fruits and bone health. Nomilin, a limonoid present in citrus fruits, is reported to have many biological activities in mammalian systems, but the mechanism of nomilin on bone metabolism regulation ...

Nomilin is a bitter compound present in citrus and has been demonstrated as useful for various disease preventions through anti-proliferative, anti-inflammatory, and pro-apoptotic activities. Although in vitro disease models have shown that certain limonoids in the p38 mitogen-activated protein ...

ObjectiveNomilin and obacunone are two important limonoids that are well known for their anticancer effect. Previous studies showed that limonoids had inhibitory effect on cytochrome P450 3A4 (CYP3A4). However these effects are inconclusive with regards to prediction of potential drug interactions.