In the current work the ability of Bacillus megaterium to take up hydrophobic substrates and efficiently express eukaryotic membrane proteins was utilized for establishing a CYP27A1-based biocatalyst. The human mitochondrial cytochrome P450CYP27A1 was co-expressed with its redox partners adrenod...

Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in...

The four diastereomeric 3,16-diacetates 6, 9, 10 and 11 were prepared from gitoxin 1 by the routes shown in Schemes 1 and 2 and tested for inotropic activity in the isolated guinea-pig atrial preparation. In line with earlier findings in the digitoxigenin series, derivatives with a 3α-acetoxy f...

(16α-3H); (4-14C)-Pregnenolone (3H: 14C ratio 3·15) was administered to two Digitalis purpurea plants and the biosynthesized digitoxigenin (3H: 14C ratio 3·17) and gitoxigenin (3H: 14C ratio 3·1) were isolated. The results indicate a direct replacement of the 16β-hydrogen of pregnenolone by...

ContextTaraxacum officinale Weber (TO) commonly known as “dandelion”, is a tropical Asian medicinal plant which contains taraxasterol (TX) and taraxerol (TA) in its roots, which are reported to be commercially important anticancer compounds.

Ethnopharmacological relevanceTaraxasterol was isolated from the Chinese medicinal herb Taraxacum officinale which has been frequently used as a remedy for inflammatory diseases. Our previous study has shown that taraxasterol inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prost...

Aim of the studyTaraxasterol, a pentacyclic-triterpene, was isolated from the Chinese medicinal herb Taraxacum officinale. In the present study, we investigated the in vitro anti-inflammatory activity of taraxasterol in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages.

Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been reported to have potent anti-inflammatory properties. However, the effect of taraxasterol on lipopolysaccharide (LPS)-induced mice acute lung injury has not been investigated. The aims of this study were to inves...

Ethnopharmacological relevanceTaraxasterol was isolated from the Chinese medicinal herb Taraxacum officinale which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo protective effect of taraxasterol on allergic asthma induced by ovalb...

Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been demonstrated to have anti-inflammatory effects. However, the protective effects of taraxasterol against cigarette smoke (CS)-induced lung inflammation have not been reported. This study aimed to investigate the p...

Osteoarthritis (OA), a chronic degenerative joint disease, is a leading cause of disability among elderly patients. Taraxasterol, a pentacyclic-triterpene isolated from Taraxacum officinale, has been shown to have anti-inflammatory effects. However, the protective effect of taraxasterol on OA re...

Ethnopharmacological relevanceTaraxasterol was isolated from the traditional Chinese medicinal herb Taraxacum which has been frequently used as a remedy for inflammatory diseases. In the present study, we determined the in vivo anti-arthritic effect of taraxasterol on arthritis induced by Freund...

Previous study has indicated that taraxasterol (TAR), one of bioactive pentacyclic triterpenes mainly isolated from Chinese medicine herb Taraxacum officinale, displays considerable anti-inflammatory effects in various kinds of models. However, its effects on rheumatoid arthritis (RA) have still...

Background and aimTaraxasterol, a pentacyclic-triterpene, has been reported to exert potent anti-inflammatory activity. However, the molecular mechanisms by which taraxasterol attenuates acute experimental colitis (AEC) remain undocumented.

This research work presents the application of proton induced X-ray emission (PIXE), to the study of carpet yarns collected from ancient Persian carpets belonging to Safavid period (1499–1722 CE). The elemental concentrations in the yarns of precious carpets were measured and compared with the ...

Fluorinated stannanes are versatile synthetic intermediates. Reaction of fluorinated vinyl, alkyl and aryl zinc or cadmium reagents with tri-n-butyltin chloride at room temperature yielded the corresponding tri-n-butyl stannanes in moderate to excellent yields. The zinc or cadmium reagents also ...

The effect of a new thyroid component, recently isolated from bovine thyroglobulin. on the respiration and swelling of rat liver mitochondria, has been studied. This product is an iodinated peptide, 3,5 diiodo-l-tyrosyl 3,5 diiodo-l-tyrosine (TT4I) and its action is quite different from that of ...

Contrary to usual observation, both venenatine (1a) and alstovenine (1b) give initially only a single oxindote derivative (3) instead of a pair. This oxindole displays unusual resistance to isomerisation in both acidic and basic media and is unique in its total insensitivity to pyridine. The unp...

The efficiency of fluorescent organic light emitting diodes (FOLEDs) is strongly affected by the fraction of singlet excitons formed. However, the standard statistical value of the single to triplet ratio is 1:3, which implies most of the excitons are invalid in fluorescent emitting devices. Her...

By introducing a highly fluorescent 9,9′-bianthracene, fluorocarbon (trifluoromethyl groups) with the different linkage mode on the periphery of the 9,9′-bianthracene core, two novel blue-emissive materials (BAn-(3)-CF3 and BAn-(4)-CF3) were synthesized and characterized. The high luminescence...