Thermal reaction (70 °C) of the dichloroazine CF3CCl=NN=CClCF3, 1, with cycloheptatriene (7) gave a complex mixture from which the major products were separated and identified as the dehydrochlorinated rearranged [32] cycloadducts 9 (28%) and 10 (23%) containing a CF3CHClN= group, a rearranged ...

The new multicomponent reaction of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-phenylisoxazol-5(4H)-one gives substituted 2,4-diamino-5-(5-oxo-3-aryl-2,5-dihydroisoxazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitriles (50–74% yields), which are promising for biomedical appl...

A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophob...

Insomnia is the most frequently encountered sleep complaint worldwide. While many prescription drugs are used to treat insomnia, extracts of valerian (Valeriana officinalis L., Valerianaceae) are also used for the treatment of insomnia and restlessness. To determine novel mechanisms of action, r...

Valeriana officinalis (Valerian) root extracts have been used by European and Asian cultures for millennia for their anxiolytic and sedative properties. However, the efficacy of these extracts suffers from variable yields and composition, making these extracts a prime candidate for microbial pro...

Dried valerian (Valeriana officinalis) root powder was stored at 5, 14 and 30 °C under low, moderate and high humidity conditions for 6 months, and the level of the valerenic acids monitored on a monthly basis. From an initial moisture content of 5 g/kg, the moisture level during storage decrea...

Nesfatin-1 is an anorexic peptide derived from nucleobindin 2 (NUCB2). An increase in hypothalamic nesfatin-1 inhibits feeding behavior and promotes weight loss. However, the effects of weight loss on hypothalamic nesfatin-1 levels are unclear. In this study, obese rats lost weight in three ways...

Potassium-promoted molybdenum oxide/alumina–zirconia catalysts were prepared by the sol–gel method. The catalysts were characterized by nitrogen physisorption, X-ray diffraction, scanning electron microscopy, Raman spectroscopy, and Fourier transform spectroscopy measurements. It was observed ...

Heats of mixing and vapour pressures of chloroform (A) + n-propanol (Bn as a function of concentration have been determined at 303.15 K. The excess Gibbs free energy of mixing, GE values, have been obtained from the measured vapour pressure data. The heats of mixing values are negative for solut...

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80–100 nm) of dipalmitoyl-phosp...

Heteroleptic iridium(III) cyclometalates, [5-(2-MeCB)dfppy]2Ir(LX) (2-MeCB = 2-methyl-o-carboran-1-yl; dfppy = 2-(4,6-difluorophenyl)pyridinato-C2,N; LX = picolinate (5a) or tetrakis(1-pyrazolyl)borate (5b)), with o-carborane at the 5-position of the phenyl ring of the dfppy ligand were prepared...

A facile and efficient method is described to greatly improve the emission efficiency of anthracene-o-carborane dyad by linking two o-carborane building blocks together through tailored alkyl linkages. Improvement of the emission efficiency of the tethered anthracene-o-carborane dyads was achiev...

In this study, we report the enhanced carrier activity of potassium cation (K+) not only with fluoride but also fluorosilicate anions, prepared by the simple heat-treatment of polymer electrolyte solution in glass vial. The formation of water-soluble fluorosilicate anions such as SiF5(H2O)– was...

A critical study of the titrimetric potassium silicofluoride method for determination of silica reveals that quantitative precipitation of the sificofluoride is possible in 3.5–7.5N acid containing 1% sodium fluoride and >/ 12% potassium chloride. An aqueous wash solution (pH ∼ 5.3) containing...

A novel counter-ion, N-methylimipramine, was synthesized and utilized in the separation of inositol phosphates by ion-pair chromatography. The structural identity of the counter-ion was documented by nuclear magnetic resonance spectroscopy. This counter-ion was capable of resolving inositol phos...

On the basis of our earlier studies in a group of 7,8-disubstituted derivatives of 1,3-dimetyl-3,7-dihydropurine-2,6-dione, a series of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydropurine-2,6-diones (8-15) were synthesized and tested for their electrocardiographic, antiar...

The reaction of [Pd(CH3CN)2Cl2] with N-cyclopentyl-1-(pyridin-2-yl)methanimine (L1), N-cyclohexyl-1-(pyridin-2-yl)methanimine (L2), N-(piperidin-1-yl)-1-(pyridin-2-yl)methanimine (L3) or N-cyclopentyl-1-(quinolin-2-yl)methanimine (L4) in ethanol yields the bidentate (NN’) PdCl2 complexes [L1PdC...

Novel [LnMCl2] complexes (Ln = LA, LB; M = Co, Cu, Zn) containing the N,N-chelating ligands N,N-bis((1H-pyrazol-1-yl)methyl)cyclopentanamine (LA) and N,N-bis((3,5-dimethyl-1H-pyrazol-1-yl)methyl)cyclopentanamine (LB) have been synthesized and characterized. The X-ray crystal structures of the Co...

The catalytic system of azo-bis-isobutyronitrile (AIBN) combined with (SiMes)Ru(PPH3)(Ind)Cl2 [M20] was investigated for the controlled radical polymerization of methyl methacrylate (MMA) in solution. Various factors that may influence the catalytic polymerization process, such as the aging time...

Ruthenium(II) complexes of Schiff base derived from cycloalkylamines (cycloalkyl = cyclopentyl (1a), cyclohexyl (1b), cycloheptyl (1c), and cyclooctyl) (1d) were synthesized: [RuCl(CyPen-Salen)(PPh3)2] (2a), [RuCl(CyHex-Salen)(PPh3)2] (2b), [RuCl(CyHep-Salen)(PPh3)2] (2c), and [RuCl(CyOct-Salen)...