A series of five different alkoxymethyl substituted derivatives of 8-hydroxyquinoline was synthesised both in protonated (1a-1e) and neutral (2a-2e) form. The alkoxymethyl groups are MeO (1a, 2a), EtO (1b, 2b), n-PrO (1c, 2c), iso-PrO (1d, 2d), n-BuO (1e, 2e). The compounds were characterised by...

A series of multitargeted 8-hydroxyquinoline derivatives were designed and synthesized for the treatment of Alzheimer’s disease (AD). In vitro studies indicated that most of the prepared compounds exhibited significant inhibitory effects against self-induced Aβ1−42 aggregation and potential an...

There is a conspicuous progress in increasing anticancer drug delivery through the utilization of nanoparticles (NPs) as drug delivery agents. Hydroxyapatite (HA) gives improved clinical effectiveness of drugs by reducing systemic toxicity and broadening the spectrum of drug delivery since it is...

Hydrochloric acid pickling treatment is used to remove mill scales from mild steel (MS) surface at diverse temperatures up to 328 ± 5 K. In order to minimize the metal dissolution newly multifunctional heterocycles based on 8-hydroxyquinoline derivatives, have been synthesized and characterized...

In this work, a 8-hydroxyquinoline derivative, named 8-hydroxyquinoline-2-carboxaldehyde 2-furoyl hydrazone (HQFUH), was obtained. The respective compound was successfully synthesized as well as its respective Zn(II) coordination compound. Both compounds were structurally characterized, by exper...

PI3Kδ is a key component in the aberrant signaling transduction in B cell malignancy, therefore specific targeting PI3Kδ has become an attractive molecularly targeted therapy for chronic lymphocytic leukemia (CLL). Herein, we describe the discovery and optimization of a series of 5-alkynyl sub...

4-MeOC6H4Te−Na+ and Te2− generated in situ by reduction of (4-MeOC6H4Te)2 and elemental Te, respectively, with sodium borohydride on reaction with 2-[3-(2-chloroethoxy)propyl]-6-methylpyridine in N2 atmosphere results in 1-(4-methoxyphenyltelluro)-2-[3-(6-methyl-2-pyridyl)propoxy]ethane (L1) 2-m...

The kinetics of hydrolysis of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (I) in aqueous solutions at 333, 343, 353 and 363 K over the pH range 0.4–4.8 was investigated. The decomposition was observed with the HPLC method (LiC...

TPEN (N,N,N′,N′-tetrakis(2-pyridylmethyl)-ethylenediamine) is a membrane-permeable heavy-metal ion chelator with a dissociation constant for Ca2+ comparable to the Ca2+ concentration ([Ca2+]) within the intracellular Ca2+ stores. It has been used as modulator of intracellular heavy metals and ...

The regulation of Ca2+ release by luminal Ca2+ has been well studied for the ryanodine and IP3 receptors but has been less clear for the NAADP-regulated channel. In view of conflicting reports, we have re-examined the issue by manipulating luminal Ca2+ with the membrane-permeant, low affinity Ca...

To elucidate the role of Zn2+-associated glutamate signaling pathway and voltage-dependent outward potassium ion currents in neuronal death induced by hypoxia–ischemia, PC12 cells were exposed to Oxygen–Glucose Deprivation (OGD) solution mimicking the hypoxic–ischemic condition in neuron, and...

Artificial oocyte activation is a critical step during SCNT. Most current activation protocols focus on inducing an increase in the intracellular free Ca2+ concentration of the oocyte. Here, we have used a zinc chelator, TPEN, to enhance the efficiency of oocyte activation during SCNT. TPEN trea...

A Triple-foil differential Plunger for Exotic Nuclei (TPEN) has been developed to measure the lifetimes of excited states in nuclei with small production cross-sections. TPEN utilises one target foil and two degrader foils to make differential lifetime measurements: directly determining the deca...

TPEN is an amino chelator of transition metals that is effective at the cellular and whole organism levels. Although TPEN of often used as a selective zinc chelators, it has affinity for copper and iron and has been shown to chelate both biologically. We have previously shown that TPEN selective...

A dinuclear FeIII complex [{Fe(TPA)Cl}2O](ClO4)2·H2O (1) where TPA is tris(2-pyridylmethyl)amine, has been synthesized and characterized by X-ray structural studies with a detailed analysis of Hirshfeld surfaces and fingerprint plots facilitating a comparison of intermolecular interactions in b...

We report in this communication the easy preparation of the α-iodo substituted tripods within the series of tris(2-pyridylmethyl)amine ligands, I1TPA, I2TPA and I3TPA, respectively. The characterization of the corresponding FeCl2 complexes in solution is described and structural analysis by X-r...

Two new Ru(II) complexes containing tris(2-pyridylmethyl)amine was synthesised by reacting [RuCl2 (EPh3)3] E = P, As with TPA.3HClO4 in 1:1 ratio. The new complexes were characterized by various spectroscopic (IR, UV–Vis and NMR) techniques and the structure of the complexes was confirmed by X-...

Two new Hg(II) coordination compounds containing the tris(2-pyridylmethyl)amine (TPA) ligand were synthesized by conventional and sonochemical methods, characterized by spectroscopic techniques (FT-IR and elemental analysis) and their X-ray crystallographic structures were determined. The crysta...

Gallarhois (GR) is a traditional oriental herbal medicine with various pharmacological effects; however, its effect on gastric ulcer has not been previously explored. We firstly investigated the component and antioxidant activity of GR extract (EtGR) by HPLC analysis and 1,1-diphenyl-2-picrylhyd...

To study neuroprotective effects of bunazosin hydrochloride which is an α1-adrenoceptor antagonist used as an ocular hypotensive drug compared to other α1-adrenoceptor antagonists, and its mechanism of action. We evaluated the neuroprotective effects of bunazosin hydrochloride or seven other α...