The purpose of this research is to investigate the effect of different oxidation degrees and volume ratios of components on the physical properties and biocompatibility of an in situ cross-linking chitosan-hyaluronic acid-based hydrogel for skin wound healing applications. Carboxymethyl groups (...

The synthesis, characterization and catalytic performance of chiral Cu(II) complexes derived from N-carboxymethylated and N-carboxyethylated amino acids is reported. The ligand precursors are prepared by single step N-alkylation of the sodium salts of the appropriate chiral amino acid with eithe...

BackgroundIn-stent restenosis, or renarrowing within a coronary stent, is the most ominous complication of percutaneous coronary intervention, caused by vascular smooth muscle cell (VSMC) migration into and proliferation in the intima. Although drug-eluting stents reduce restenosis, they delay t...

The biflavonoid morelloflavone has been reported as inhibitor of secretory PLA2s (phospholipases A2 from human synovial and bee venom sources); however, its capacity to interact and inhibit snake venom PLA2 activities has not been described. In this work we tested the inhibitory ability of morel...

2,5-Dimethyl-2′-hydroxy-9α-(3-methylbutyl)-6,7-benzomorphan, the 9β-analogue, and 9α-N-substituted (N-ethyl, propyl, butyl, pentyl, hexyl, phenylethyl, allyl, and cyclopropylmethyl) compounds were synthesized and evaluated biochemically and pharmacologically. The 9β N-methyl compound was fo...

A series of biodegradable functional amino acid-based poly(ester amide)s (PEA-AG) were designed and synthesized by the solution co-polycondensation of amino acid (l-phenylalanine and dl-2-allylglycine) based monomers and dicarboxylic acid based monomers. Pendant carbon–carbon double bonds locat...

An electrochemical DNA biosensor was fabricated by self-assembling probe single-stranded DNA (ssDNA) with a nanogold decorated on ionic liquid modified carbon paste electrode (IL-CPE). IL-CPE was fabricated using 1-butylpyridinium hexafluorophosphate as the binder and the gold nanoparticles were...

The telomerization of 3-(trimethoxysilyl)propyl methacrylate (TMSPMA) in the presence of 2-mercaptoethanol was investigated at 80 °C in acetonitrile. In our case, the efficiency of 2-mercaptoethanol as telogen agent, with TMSPMA, was demonstrated and the transfer constant (CT) was determined. M...

The effect of structural variations of either the donor (number and position of methoxy groups, replacement of the aryl by Fischer's base) or the acceptor moiety (bisacylation of the amino group, extension of the conjugated system by condensation with dimethylformamide–dimethylacetale) of ...

Kinetics of copolymerization reactions of 2-(dimethylamino)ethyl acrylate (DMAEA) and styrene by reversible addition fragmentation transfer (RAFT) in N,N-dimethylformamide (DMF) are reported. Novel approaches in the online monitoring of the synthesis of the amphiphilic copolymers by Automatic Co...

Temperature and pH double-response poly(t-butyl acrylate)-b-poly{[2-(dimethylamino) ethyl methacrylate]-co-[poly(ethylene glycol) methyl ether methacrylate]} (PtBA-b-P(DMAEMA-co-PEGMEMA)) were successfully prepared by RAFT polymerization and could be self-assembled into micelles. 1H NMR, UV-vis ...

SummaryThe increase in drug concentration in aqueous solutions is not responded to by a comparable enlargement of volume of necrosis after intramuscular injection. After application of TURIMYCIN the lesion is more voluminous than those caused by penicillin, lower than those following OTESOLUT an...

Quantitative thin-layer chromatographic determination of the macrolide antibiotic turimycin H and some of its degradation products by densitometric in situ measurement with the image analyser “Quantimet 720”A method for the quantitative determination of the macrolide antibiotic complex turimyc...

AimsJosamycin has immunomodulatory properties independent of its antibacterial actions. This study was designed to explore the influences and associated mechanisms of josamycin upon the generation of proinflammatory mediators in murine macrophages activated with lipopolysaccharide (LPS) from Pre...

The degree of substitution (ds) and the distribution pattern of the two ester substituents in commercial samples of cellulose acetate–butyrate (CAB) were determined by sequential neutral methylation, direct reductive cleavage and in situ acetylation. When the reductive-cleavage reaction was con...

The structure of the 1:2 complex of 2-quinuclidinium-butyrate, QNBu, with p-hydroxybenzoic acid, HBA, (1) has been determined by X-ray diffraction, DFT calculations, and the complex was characterized by FTIR and NMR spectroscopy. The crystals are triclinic, space group P1¯. The QNBu and HBA mol...

A novel expression system for Corynebacterium glutamicum, based on the transcriptional activator of propionate metabolism genes PrpR and its target promoter/operator sequence, was developed and tested. The activator PrpR is co-activated by propionate added to the growth medium. In a minimal medi...

One-step synthesis of acrylates from acetates and trioxane via aldol reaction at 623 K–653 K was reported. But proceeding this process at room temperature is still a challenge due to ester activation and trioxane decomposition. Herein, series of acrylates were firstly achieved, with the one-ste...

Rosa damascena Mill. is one of the most important plants from Rosaceae family, with a long historical use in the traditional medicine and as a valuable oil bearing plant. The rose scent derived as oil, concrete or absolute, is one of the world most sought-after products and the development of re...

The 2-methylcitrate cycle is used to metabolize propionate in Corynebacterium glutamicum. The regulator, PrpR (Cg0800), of the prpDBC2 operon was identified and characterized. The regulator has no similarities to the up to now known PrpR regulators from other organisms. Growth of a ΔprpR mutant...