Reactions of 2-amino-2-deoxy-d-glucose and 1-amino-1-deoxy-d-fructose with nitroacetone produced 2-methyl-3-nitro-5-(d-arabino-tetritol-1-yl)pyrrole (7) and 2-methyl-3-nitro-4-(d-arabino-tetritol-1-yl)pyrrole (11), respectively, in good yields. The reactions take place through the intermediacy o...

The convenient one-pot synthesis of 5-nitropyridines based on the tricomponent cyclocondensation of nitroacetone, triethyl orthoformate and various enamines has been developed.

Publisher SummaryThis chapter focuses on the anaerobic degradation of nicotinic acid. Fermentation of nicotinic acid by Clostridium species leads to the formation of 1 mole each of propionate, acetate, CO2, and ammonia. Nicotinic acids containing 14C-labeling in various positions of the pyridine...

The reactions of Fe3(CO)12 with 2-methyl-3-butyn-2-ol and 3-pentyn-1-ol in CH3OH/KOH solution lead, respectively, to the binuclear complex Fe2(CO)6(μ-CO)(μ-η2-[HCC{C(CH3)2}C(O)(OCH3)]) (as the main product) and to the closed trinuclear hydridic complex (μ-H)Fe3(CO)9(μ3-η3-[H3CCC(CH2)(CH2)C...

The complex Co2(CO)6[μ-η2-(H3CCCCH2CH2OH)] (1) with the ligand 3-pentyn-1-ol (pol) has been synthesized following established procedures. Its structure has been determined by X-ray analysis. The complex Co2(CO)6(mbo) (mbo = 2-methyl-3-butyn-2-ol, HCCC(CH3)2OH), (3), along with the already know...

A G–L–S “slurry Taylor” flow is investigated for the three-phase catalytic hydrogenation of 3-methyl-1-pentyn-3-ol in a capillary reactor. A system to continuously feed a homogeneous liquid–solid suspension without flow fluctuation is designed and validated allowing delivery of a stable and...

In bacterial photosynthetic membranes the generation of a transmembrane ΔpH coupled to ATP hydrolysis is detected by monitoring the quenching of fluorescence of the monoamine 9-amino-6-chloro-2-methoxyacridine (ACMA), induced in the dark upon addition of the substrates of the ATPase reaction. W...

9-Amino-3-azido-7-methoxyacridine has been synthesized and shown to be a suitable photoaffinity probe for the site(s) of interaction of 9-amino-3-chloro-7-methoxyacridine with submitochondrial membranes. Both the excitation and emission spectra of the azido analogue covalently bound to membranes...

Pyrazoloacridine (PZA) is a 9-methoxy substituted acridine with a reducible nitro group. PZA has shown selective solid tumor cytotoxicity with activity against hypoxic cells, non-cycling cells and cells expressing the multidrug resistant phenotype. A high-performance liquid chromatographic (HPLC...

A colorimetric assay for hydralazine hydrochloride based on the interaction of the drug with 9-methoxyacridine is described. The highly colored substituted 9-aminoacridine product shows an absorption maximum at 455 nm. Color development is affected by time of heating or standing at ambient tempe...

Spectrophotometric assay for cycloserine based on the interaction of the drug with 9-methoxyacridine as a chromogenic agent is described. The highly colored substituted acridine product was identified as 9-(d-4-imino-3-isoxazolidinone)acridine. Color development was affected by time and temperat...

Spectral features of 4-(methylamino)-3-nitrobenzoic acid (MNA) have been probed by the techniques of Fourier transform infrared, Raman and UV–visible combined with density functional theory calculations at the B3LYP level with 6–311++G(d,p) basis set. By using potential energy distribution the...

The structure and electronic spectra of 2-methylamino-6-methyl-4-nitropyridine N-oxide (2M6M) were investigated. The X-ray structure of 2M6M molecule shows that it crystallizes in the monoclinic system of the P21/n space group and forms internally hydrogen-bonded [NH…O = 2.563(3) Ǻ] monomers li...

IntroductionMetabotropic glutamate subtype receptor 1 (mGluR1) is implicated in several neuropsychiatric disorders and is a target for drug development. [18F]FIMX ([18F]4-fluoro--N-methyl-N--(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide) is an effective radioligand for imaging brain m...

X-ray crystal structures of two isomers C8H11N3O3, i.e. 2-N-ethylamino-5-methyl-4-nitropyridine N-oxide (EN5MPO) and 2-N-ethylamino-3-methyl-4-nitropyridine N-oxide (EN3MPO) have been determined. The different substitutions of the CH3 groups lead to change of the unit-cell structure, molecular a...

In the present work, molecular structures and intramolecular hydrogen bonding (IHB) of 3-methyl-4-amino-3-penten-2-one, 3-MeAPO, 3-methyl-4-methylamino-3-penten-2-one, 3-Me-MeAPO, and the 3-methyl-4-phenylamino-3-penten-2-one, 3-Me-PhAPO have been investigated by means of density functional theo...

Adjuvants are substances that, when combined with an antigen in a vaccine formulation, potentiate the immune response against that antigen. Aluminium hydroxyphosphate is among the currently used adjuvants in vaccines, while studies on its iron analogue, ferric hydroxyphosphate, are quite limited...

A non-heme tetra-iron cluster, [Fe4III(μ-O)2(μ-OAc)6(2,2′-bpy)2(H2O)2](NO3−)(OH−) (1), [OAc = acetate; 2,2′-bpy = 2,2′-bipyridine] containing oxido- and acetato-bridges was synthesized and structurally characterized by different spectroscopic methods including single crystal X-ray diffracti...

A friendly method for the protection of diols and carbonyls catalysed by hexahydrated iron (III) chloride has been developed. This method, which consists of the transformation of diols and carbonyls to cyclic acetals, functions in mild conditions and it is efficient for a wide range of diols.

This paper deals with a simple and low-cost method developed to deposit hematite (α-Fe2O3) layers on a fluorine-doped tin oxide (FTO/F:SnO2) substrate by thermal decomposition of solid iron(III) chloride hexahydrate (FeCl3⋅ 6H2O). Deposition procedure takes place through chemical intermediate i...