Increased blood pressure variability has been shown to be associated with cardiovascular morbidity and mortality. Recently we reported that continuous infusion of angiotensin II not only elevated blood pressure level, but also increased blood pressure variability in a manner assumed to be indepe...

BackgroundHypertension is a serious component of metabolic syndrome (MetS).

The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efon...

Azelnidipine, dihydropyridine based calcium channel blocker has been used for treating ischemic heart disease and cardiac remodeling after myocardial infarction but it is having a low bioavailability due to its poor solubility. The present study is to investigate the formulation and evaluation o...

In an effort to develop a new type of HCV NS3 peptidomimetic inhibitor, a series of tripeptide inhibitors incorporating a mix of α- and β-amino acids has been synthesized. To understand the structural implications of β-amino acid substitution, the P1, P2, and P3 positions of a potent tripepti...

Colored wheat varieties and crosses were analyzed to figure out their anthocyanin profiles, and thus, their potential as health-related food. After method development, the obtained 94 anthocyanin fingerprints allowed the clear differentiation of the blue aleurone and purple pericarp genotypes as...

Solvent swelling of polymers is of major importance in organic solvent nanofiltration (OSN) affecting membrane rejection of 200–1000+ Da solutes. A selected perfluoro type amorphous glassy copolymer, perfluoro-2,2-dimethyl-1,3-dioxole copolymerized with tetrafluoroethylene (PDD-TFE), is complet...

Massive consumption of petroleum since the past century has led to considerable emissions into marine ecosystems. Marine sediments may accumulate substantial quantities of petroleum and associated contaminants in oil-producing areas. Here, we report accelerated accumulation of total petroleum hy...

Deep eutectic solvent (DES), has been considered as a new type of green solvent applied in enzymatic systems. Here, we reported DES-buffer co-solvent as a novel reaction medium for high efficient synthesis of cefaclor by penicilin acylase immobilized on magnetic nanocrystalline cellulose. Effect...

In this work, the PVDF/glass as-prepared composite membrane was prepared through phase-inversion method and used to adsorb methylene blue dye. The results of SEM and BET showed that the membrane had an asymmetric nanoscale porous structure. The electronegativity on the surface of membrane was de...

Sugaring-out is a novel phase separation method which was found firstly in the separation of acetonitrile. Nowadays sugaring-out extraction was tried in the recovery of metal ions, biomolecules, drugs and proteins, while its application in separation of hydrophilic primary metabolites from ferme...

The reaction kinetics of 2,3-butanediol (2,3-BDO) and other key intermediates, including methyl ethyl ketone (MEK), 2-methylpropanal, acetoin, 2-butanol and 2-methyl-1-propanol, were investigated over acidic zeolites (ZSM-5, and Y-type zeolite), Cu/ZSM-5, Cu/Y and Cu/SiO2 to elucidate the roles ...

In this paper, a complete separation process for 2,3-butanediol fermentation broth has been developed using reactive-extraction and reactive-distillation. n-Butylaldehyde can be used as both reactant and extractant in the process. Equilibrium and kinetics were studied on the reaction between 2,3...

In this study, we demonstrate the conversion of starch to (R,R)-2,3-butanediol (2,3-BD) in a hybrid cell-free synthesis system containing a mixture of lysates derived from Escherichia coli (E. coli) and cyanobacteria. A sufficient pool of pyruvate required for the synthesis of 2,3-BD was generat...

The pathway engineering of Enterobacter aerogenes was attempted to improve its production capability of 2,3–butanediol from lignocellulosic biomass. In the medium containing glucose and xylose mixture as carbon sources, the gene deletion of pflB improved 2,3-butanediol carbon yield by 40%, whil...

Various strategies were studied to enhance 2,3-butanediol production using Enterobacter aerogenes SUMI014. The synergistic effect of acetate improved yield and productivity, and resulted in 32.3% increase in 2,3-butanediol production, compared to the wild strain. Optimizing the fermentation cond...

This study demonstrates the effective use of a bacterial isolate as a biocatalyst converting wastes to 2,3-butanediol. The developed microbial catalyst Enterobacter cloacae TERI BD 18 was robust as it can grow in wastes with high concentration of impurities showing the potential for developing a...

Catalysts able to selectively dehydrate 2,3-butanediol into butadiene have been designed. These catalysts, based on rare-earth orthophosphates showed that 58% selectivity to butadiene could be obtained at total conversion at only 300 °C, and were relatively stable. While the deactivation could ...

The present study aims to develop a process for the production of 2,3-butanediol by Simultaneous Saccharification and Fermentation (SSF) of Oil Palm Front (OPF) biomass. The study compares SSF with Separate Hydrolysis and Fermentation (SHF) of oil palm biomass and batch fermentation using glucos...

The enhanced production of 2,3-butanediol was investigated using a metabolic engineering approach and optimized fermentation conditions. New engineered strains of Enterobacter aerogenes ATCC 29007 were developed by deleting the d-lactate dehydrogenase (ldhA), phosphate acetyltransferase (pta), m...