Rufinamide is an antiepileptic drug approved for seizures treatment associated with Lennox-Gastaut syndrome. To support future pharmacokinetic studies in rodents, this work aimed to validate for the first time a fast and simple high-performance liquid chromatographic (HPLC) method for rufinamide...

The Fifth Eilat Conference on New Antiepileptic Drugs (AEDs) took place at the Dan Hotel, Eilat, Israel, 25–29 June 2000. Basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included recognition of unexpected adverse effects, ...

The 2:1 and 1:2 adducts of Au(I) and 1:2 adducts of Ag(I) with the diphosphine 2,3-bis(diphenylphosphino)maleic acid (dpmaa) have been prepared in high yields. Crystal structures have been determined for the neutral digold complex (AuCl)2(dpmaa) · 2thf (1) and the bis-chelated complex [Au(dpmaa...

2-epi-Jaspine B has been synthesized starting from (−)-diethyl tartrate in 12 simple steps and 26.6% overall yield. The key intermediate was obtained via stereoselective base-catalyzed intramolecular oxy-Michael conjugate addition followed by tandem hydrogenation/hydrogenolysis.

Novel iridium-based sensitizers Iridium(III) bis[2-phenylpyridinato-N,C2′]-5-carboxylpicolinate) (Ir1), Iridium(III) bis[2-(naphthalen-1-yl) pyridinato-N,C2′]-5-carboxyl-picolinate) (Ir2), Iridium(III) bis[2-phenylpyridinato-N,C2′]-4,4′-(dicarboxylicacid)-2,2′-bipyridine (Ir3) were synthesi...

The synthesis and characterization of new cyclometalated complex salts [M(ptpy)2(4,4́-HOCH2bpy)]PF6 (M = Rh, 1; M = Ir, 2 and M = Ru, 4; ptpy = 2-(p-tolyl)pyridinato; 4,4́-HOCH2bpy = 4,4́-bis(hydroxymethyl)-2,2́-bipyridine) is reported. Compounds 1 and 2 were obtained by bridge-splitting reactio...

The synthesis and characterization of new cyclometalated complex salts [M(C^N)2(4,4′-Cl2bpy)]PF6 (M = Rh and Ir; C^N = 2-(p-tolyl)pyridinato (1 and 2), 2-phenyl-5-chloro-pyridinato (3 and 4); 4,4′-Cl2bpy = 4,4′-dichloro-2,2′-bipyridine) is described. Compounds 1–4 were obtained by reaction ...

A sensitive enantioselective liquid chromatographic assay with mass spectrometric detection (LC–MS) has been developed and validated for the simultaneous determination of saliva concentrations of (R)- and (S)-methadone (Met) and (R)- and (S)-2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine (E...

The mesomorphic properties of newly synthesized homologous series of calamitic liquid crystals; methyl 4-[4-(4-alkoxy benzoyloxy)benzylideneamino]benzoates, H2n+1CnOC6H4COOC6H4C(H)N C6H4COOCH3; n = 6, 8, 10, 12, 14, 16 (MABBAB-n) containing ester and Schiff base groups as linker have been studie...

We synthesized a series of 4-tert-butylcalix[4]arene nitriles (5–7) by the reaction of 4-tert-butylcalix[4]arene (1) with 4′-(6-bromohexyloxy)biphenyl-4-carbonitrile (2), 4′-(10-bromode-cyloxy)biphenyl-4-carbonitrile (3), and 4′-(12-bromododecyloxy)biphenyl-4-carbonitrile (4) and characteriz...

The unprecedented (±)-2-methoxy-4-oxatetradecanoic acid and the optically pure (S)-2-methoxy-4-oxatetradecanoic acid were synthesized in six steps and in 11–14% overall yields starting with either 1,2-O-isopropylidene-rac-glycerol or 1,2-O-isopropylidene-(S)-glycerol. The key step in the synth...

A new optical chemical sensor based on the recently synthesized azo dye, 4-decyloxy-2-(2-pyridylazo)-1-naphthol (DPAN), immobilised in Nafion membranes is reported. The sensing membranes cast onto glass substrates and integrated into a flow-through measuring cell were homogeneous, transparent, m...

In this study, firstly, retention behavior of solvents on the liquid crystalline material 4-decyloxybiphenyl-4′-carboxylic acid (DBCA) has been studied by inverse gas chromatography (IGC) technique. Liquid crystal (LC) selectivity was investigated using the acetate isomers by the IGC method at ...

In this study, 5,8-dibromo-2,3-bis(4-(decyloxy) phenyl) pyrido[4,3-b]pyrazine was synthesized and used as the acceptor unit, which then be coupled with three thiophene derivatives (3-methylthiophen, 3-methoxythiophen and 3,4-dimethoxythiophen) to give rise to three novel monomers, 2,3-bis(3-meth...

A new liquid crystalline material containing diester linking group ethyl-[4-(4′-decyloxy)benzoyloxy]-benzoate (4-EDBB) was synthesized. The phase transition temperatures were noted by differential scanning calorimetry (DSC), the texture pattern were observed by polarizing optical microscopy (PO...

Liquid crystalline compound 4-n-(decyloxy) benzoic acid has been irradiated by Li ion beam in its crystalline phase at room temperature by a pelletron beam using 3 nA current. Thermodynamic, dielectric and UV–Visible spectroscopic characterization of the pure and irradiated materials has been c...

The Raman spectra of a liquid crystalline system, 4-Decyloxy benzoic acid (4DBA) have been recorded at different temperatures within the interval 300–78 K in order to identify the structural changes in crystalline state of a nematogen and to understand the molecular alignment therein. The earli...

A functional evaluation of the recently developed cholecystokinin type-B (CCK-B) receptor antagonist YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea]was undertaken in Chinese hamster ovary cells stably expressing the human CCK...

SummaryWe describe a double blind trial of lymecycline, demethylchlortetracycline and methacyline in 190 patients suffering exacerbations of chronic bronchitis with purulent sputum. The dose given of all three compounds was 1200 mg or its equivalent daily for fourteen days. The three compounds w...

A method has been developed that will quantitatively analyze 0.1 μg demethylchlortetracycline-HCl and tetracycline-HCl in bone. Interference from the bone itself prevents accurate measurements at lower levels. The procedure has been successfully used to analyze the tetracycline deposited in bon...